Navigation Links
Early life infections increase the risk of rheumatoid arthritis and juvenile idiopathic arthritis

Paris, France, Friday 13 June 2008: Infections during the first year of life are a marker of increased risk of developing specific types of arthritis later in life, according to new research from Sweden presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France. Researchers from the Karolinska Institute in Sweden found that infants who were hospitalised for infection before their first birthday had an increased likelihood of developing either juvenile idiopathic arthritis (JIA) or adult rheumatoid arthritis (RA) in later life.

Investigator Dr Cecilia Carlens of The Karolinska University Hospital, Stockholm, Sweden, said: "Whilst recent research has suggested that early life infections are of importance to the maturation of the immune system in general, our analysis shows a link between perinatal infection and increased RA and JIA risk in particular, highlighting the importance of a child's formative months on his or her rheumatic health in later life."

The Swedish register-based case-control study reviewed recorded data on individuals born nationwide between 1973 and 2002, and involved 333 RA patients and 3,334 JIA patients. The analysis revealed that an increase in infections within the first 12 months is associated with an increased risk of developing JIA (odds ratio =1.9, 95% confidence interval 1.7-2.1) and sero-negative RA (odds ratio =2.6, 95% confidence interval 1.0-7.0), a distinct type of RA that is less aggressive than sero-positive RA.

However, other parts of the study suggested that perinatal charactertics, such as low birth weight (odds ratio =0.7, 95% confidence interval 0.5-1.0) and the duration of the gestational period may also affect arthritis risk in later life. A longer gestational period of over 42 weeks, emerged as a potential risk factor for developing JIA (odds ratio =1.5, 95% confidence interval 1.2-2.0).

The patient data reviewed was taken from the Swedish Inpatient Register and the Early Arthritis Register. Using the Swedish Medical Birth Register, four controls were randomly selected per case, matched by sex, year, and delivery-unit. Linkage to the Medical Birth Register and the Swedish Inpatient Register provided the necessary information on maternal-, pregnancy- and birth-characteristics, and infections during first year of life. Univariate odds ratios (OR) were calculated using conditional logistic regression.


Contact: Rory Berrie / Camilla Dormer
European League Against Rheumatism

Related medicine news :

1. HUMIRA(R) (adalimumab) Data Show That Treating Early Rheumatoid Arthritis With Combination Treatment Resulted in Cost Savings From Improved Work Productivity
2. Spotting Vitamin-D Deficiency in the Absence of Symptoms: ZRT Laboratorys New, One-of-a-Kind Blood Spot Test Answers the Call for Early Detection of Rapidly Rising D-Deficiencies
3. JCI online early table of contents: June 12, 2008
4. Canary Foundation and American Cancer Society Award Five Postdoctoral Fellowships in Early Cancer Detection
5. 19th Annual Susan G. Komen National Race for the Cure(R) Draws Nearly 50,000 Participants, Celebrities; Brings Record Funds to National Capital Area
6. JCI online early table of contents: June 5, 2008
7. Nearly 1 in 5 teenagers admit eating problems, but anxiety is a bigger problem than appearance
8. Being Born Small, Early Raises Autism Risk
9. Blacks, Hispanics less likely than whites to receive follow-up radiation for early breast cancer
10. Breast-Specific Gamma Imaging (BSGI) Found to Be Highly Sensitive for Early Stage Breast Cancer
11. Paclitaxel Plus Chemo Improves Outcomes in Early Breast Cancer
Post Your Comments:
(Date:11/29/2015)... Los Angeles, Ca (PRWEB) , ... November 29, 2015 , ... ... from the American Board of Ophthalmology on November 25th 2015. Peer Certification ... in the field of his specialty. Certification in Ophthalmology is first obtained after the ...
(Date:11/29/2015)... ... November 29, 2015 , ... Effective immediately, every single IguanaMed scrub ... on Black Friday Target is offering a “Buy One Scrub Set, Get the 2nd ... opportunity to purchase IguanaMed at a discounted price. , IguanaMed’s mission is ...
(Date:11/28/2015)... ... November 28, 2015 , ... Trying to relax on a couch ... BUDDY. "I conceived of this design due to personal experience with a bad back," ... promotes relaxation and convenience, as well as increases support. It also makes it easier ...
(Date:11/27/2015)... , ... November 27, 2015 , ... According to an ... recent 2015 American Dental Association meeting in Washington D.C. revolved around the fact that ... patient’s overall health. The talk stressed the link between periodontal disease (more commonly referred ...
(Date:11/27/2015)... ... November 27, 2015 , ... A team of Swiss doctors has released ... Surviving Mesothelioma has just posted the findings on the website. Click here to ... cases of 136 mesothelioma patients who were treated with chemotherapy followed by EPP surgery. ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Drug Monitoring (TDM) Market: Supplier Shares, ... Opportunities"  report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Marker Testing Market: Supplier Shares, ... their offering.  --> ... the  "2016 Future Horizons and Growth ...
Breaking Medicine Technology: