Navigation Links
Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index
Date:1/26/2012

The lung clearance index (LCI) is a sensitive non-invasive marker of early lung disease in young children with cystic fibrosis (CF), according to a new study from Australian researchers.

"We found that LCI is elevated early in children with CF, especially in the presence of airway inflammation and Pseudomonas aeruginosa," said Yvonne Belessis, MBBS, MPH, PhD, respiratory staff specialist at the Sydney Children's Hospital. "LCI may not only be a marker of early CF lung disease, but may be useful as an objective outcome measure in future studies of young children with CF."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

LCI was determined after multiple breath washout (MBW) testing in 47 presymptomatic/minimally symptomatic infants and young children with CF (mean age 1.55 years) and 25 healthy control children (mean age 1.26 years). Bronchoalveolar lavage (BAL) was also performed in the children with CF.

Mean (SD) LCI in children with CF was 7.21 (0.81), compared with 6.45 (0.49) in control children (P<.001). The upper limit of normal for LCI was 7.41. Among the 47 children with CF, 15 (32%) had an elevated LCI. Measurements of LCI were repeatable and reproducible.

Airway infection (≥105 cfu/mL BAL fluid) was detected in 17 (36%) children with CF, including 7 (15%) children who had Pseudomonas aeruginosa infection. LCI in children with Pseudomonas was 7.92 (1.16), compared with 7.02 (0.56) in children without Pseudomonas (P=.038). LCI was significantly correlated with the BAL inflammatory markers interleukin-8 and neutrophil count.

There were some limitations to the study, including the lack of a robust measure of structural lung disease and a higher diagnostic threshold for airway infection than has been used in other BAL studies.

"We obtained reproducible measurements of LCI
'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Optimal Heart Health Starts Early: Study
2. Drug May Slow Early Prostate Cancer: Study
3. Rate of physician referrals nearly doubled
4. Small Stem Cell Study Claims Early Success in Treating Eye Disease
5. New test offers greater accuracy in early detection of colorectal cancer
6. JCI online early table of contents: Jan. 17, 2012
7. Is Continued Lip-Reading an Early Sign of Autism?
8. Tests Might Someday Help Spot Early Lung Cancer
9. Disruption of biological clocks causes neurodegeneration, early death
10. Early-stage breast cancer patients lack knowledge; may not receive treatment they prefer
11. Hopkins researchers find Google Flu Trends a powerful early warning system for emergency departments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... (PRWEB) July 12, 2014 “Critical ... - New and Late-Stage Four-Factor PCCs and Recombinant ... of the critical care market in the US, ... The report provides an estimation of market size ... It covers critical care indications that are being ...
(Date:7/12/2014)... Lake City, Utah (PRWEB) July 12, 2014 ... spotlighted two types of startups, with awards being bestowed ... new emphasis spotlighted Utah’s outstanding entrepreneur community with recognition ... proving a sustainable model with incoming revenue. , 25 ... from across the state that are under 5 years ...
(Date:7/12/2014)... 2014 Praeclarus Press is ... a valuable new resource for women in need of ... women work away from their children. Today’s mothers receive ... of breastfeeding, but often feel unsupported when it comes ... With its evidence-based insights, and written by Nancy Mohrbacher, ...
(Date:7/12/2014)... Los Angeles, CA (PRWEB) July 12, 2014 ... a buyer power score of 4.1 out of ... the market that have been underpinning buyer negotiation ... to IBISWorld procurement analyst Anna Son, “during the ... along with rising costs associated with new product ...
(Date:7/12/2014)... it doesn't matter what your budget is, the trendy wedding ... affordable gown can visit Discount-Dress.com (a reliable online ... items. Recently, the company has announced its new selection of ... it is also providing great discounts for these unique items. ... this promotion is July 29, 2014. , Discount-Dress.com is ...
Breaking Medicine News(10 mins):Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2
... peer pressure to share sexual images via the new phenomenon ... has found. ,Sexting, is the practice of sending and ... study is one of the first academic investigations into ,sexting, ... presented to the 2011 Australasian Sexual Health Conference in Canberra. ...
... -- Unspoken clues -- like behavior and appearance -- ... Researchers from the University of Michigan found subtle, nonverbal ... view their relationship with their doctor, they also affect ... better understand how they make decisions and what underlying ...
... Picky eating is normal in children, but a pediatric feeding ... a child,s physical and mental development, an expert says. ... clinical director of the Pediatric Feeding Disorders Program at the ... reject certain foods but still has a nourishing diet. Children ...
... (Sept. 29, 2011) Six leaders in stem cell ... key presenters at the world,s largest interdisciplinary stem cell ... World Stem Cell Summit, co-sponsored by the Cedars-Sinai Regenerative ... stem cell and regenerative medicine community. The Summit ...
... 29 (HealthDay News) -- Working rotating shifts is not ... to new Canadian research that suggests modern shift patterns ... older, more extreme shift schedules. "Recent research has ... although the biological mechanism responsible for this observation is ...
... J. Stang, Ph.D., editor of the Journal of the ... Jacqueline K. Barton, Ph.D. and Rakesh Agrawal, Ph.D., are ... to receive the nation,s highest honors in science and innovation. ... is guided by a passion for innovation, fearlessness even as ...
Cached Medicine News:Health News:'Sexting' driven by peer pressure 2Health News:Doctors Consider Nonverbal Cues in Medical Decisions 2Health News:Does Your Picky Eater Have a 'Feeding Disorder'? 2Health News:Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit 2Health News:Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit 3Health News:Modern Shift Work Patterns May Be Less Harmful to Health 2Health News:White House honors editor of American Chemical Society journal and 2 ACS members 2
(Date:7/11/2014)... , July 11, 2014 Research and ... "Global and Chinese Medical X-ray Film Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 Global And Chinese Medical ... in-depth study on the current state of the Global ... Chinese situation. The report provides a basic overview ...
(Date:7/11/2014)... July 11, 2014  Kindred Hospital Houston Northwest, ... the opening of its new outpatient wound healing ... to people with chronic, hard to heal wounds. ... lead to amputation, lower leg wounds related to ... closure, and traumatic injury wounds which are complex ...
(Date:7/11/2014)... ALBANY, New York , July 11, 2014 /PRNewswire/ ... published by Transparency Market Research "Endoscopy Devices Market (Endoscopes, ... Analysis, Size, Share, Growth, Trends and Forecast, 2013-2019" the ... billion in 2012 and is expected to grow at ... reach an estimated value of USD 36.9 billion in ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6
... 2011 /PRNewswire-iReach/ -- In the world of veterinary ... is a 1 in 9 chance of anesthetic complications and ... cats. It is with great pride that LEI Medical ... history; having never had a single, equipment-related animal death reported. ...
... Medical Inc., a leader in developing minimally invasive medical ... tissue from the gastrointestinal tract, announces today that they ... Covidien.  Covidien is a leading global provider of healthcare ... Covidien will acquire all of the ...
Cached Medicine Technology:LEI Medical Emerges as an Innovator and Leads the Way in Safety 2LEI Medical Emerges as an Innovator and Leads the Way in Safety 3BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 2BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 3
The PC4200h is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
The PC4200i is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
... Platelet incubators hold rotators ... Incubator temperature can be set ... from 15C to 40C (59F ... 0.5C from top to bottom. ...
ELISA for detection of Anti-Gliadin IgA....
Medicine Products: