Navigation Links
Early clinical data show galeterone safe, effective against prostate cancer
Date:3/31/2012

CHICAGO Patients with castration-resistant prostate cancer had limited side effects and in many cases a drop in prostate-specific antigen expression with galeterone (TOK-001), a small-molecule oral drug, according to phase I data presented at the AACR Annual Meeting 2012, held here March 31 - April 4.

Castration-resistant prostate cancer (CRPC) is an advanced form of prostate cancer that occurs when the disease progresses after treatment with androgen deprivation therapy. Galeterone works against CRPC by blocking the androgen receptor, reducing levels of the ligand that binds to the receptor and degrading the androgen receptor protein.

"This drug has a novel combined mechanism of action," said co-lead researcher R. Bruce Montgomery, M.D., associate professor of medical oncology at the University of Washington School of Medicine in Seattle, Wash. "Cancer cells are sly and mutate to get around drugs. The fact that this drug hits the prostate cancer cell in three different ways may help prevent resistance. It is a well-tolerated drug that could potentially be more effective than drugs we have now."

In the ARMOR1 study, Montgomery and colleagues assigned 49 patients with CRPC to one of eight dose regimens in single or split oral escalation doses of 650 mg, 975 mg, 1,300 mg, 1,950 mg or 2,600 mg every day for 12 weeks. None of the patients had received chemotherapy for their prostate cancer.

Researchers reported that no patients reached a maximum tolerated dose. Most side effects were minor and included fatigue, nausea and diarrhea. Researchers observed transient, nonserious elevated liver function tests in 15 patients, many of whom were asymptomatic. Eleven of these patients temporarily stopped galeterone treatment, and six returned to treatment with no recurring liver function test elevations. One serious complication occurred involving rhabdomyolysis in the setting of simvastatin therapy and underlying renal insufficiency. '/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Minnesota Department of Health Report: Nearly 6,000 Hospitalizations for COPD in 2007
2. Moms Lifestyle in Early Pregnancy Affects Babys Size
3. Early life stress may predict cardiovascular disease
4. MDS Announces Agreements to Divest MDS Pharma Services Early Stage Business
5. Alzheimers Association Applauds Social Security Administration for Adding Early-Onset Alzheimers to Its Compassionate Allowances Initiative
6. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
7. JCI online early table of contents: Feb. 15, 2010
8. 29 Clear Channel stations Nationwide Raise Nearly $2.8 Million to Help Save the Lives of Kids Fighting Cancer and Other Deadly Diseases
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Early On, Hormone Therapy May Raise Womens Heart Risks
11. FriendsofWater.com Responds to the National Acadamy of Sciences Report that Millions of Americans Get Sick Yearly from Contaminated Water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... December 20, 2014 An improving macroeconomic ... have benefited the Massage Services industry over ... of industry products, the anticipated 1.0% annualized increase in ... provided consumers with the means to afford additional massages. ... a massage in a given year has declined from ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 Recently, VogueQueen.com, ... its VogueQueen Big Sale Online for 2015. ... products. All new and old consumers can get a ... order at the company’s website before January 30, 2015. ... prom dresses and launched a prom dress promotion. Many ...
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 The ... has caused quite a stir, not only in Hollywood, but ... on December 18th , the ripples of that attack are ... executives’ very jobs at risk. But they are not ... correspondences exposed could be in for some embarrassing times ahead, ...
(Date:12/20/2014)... Phoenix, AZ (PRWEB) December 20, 2014 ... of professional technicians with years of experience in contractor ... of dedicated contractor services for the homeowners of Arizona. ... dependable team a professional contractor technicians that make customer ... in 1974 in Phoenix Arizona and started with one ...
(Date:12/19/2014)... 19, 2014 Sub Zero Ice Cream is ... blood drive Sunday the 28th from 2pm-6pm at the Expo ... Road in Sarasota, FL. , Inquiries regarding time slots and ... participating in the donating process, Sub Zero Ice Cream & ... custom ice cream. , About Sub Zero Ice Cream & ...
Breaking Medicine News(10 mins):Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 2Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 3Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2
... of Dental Research (IADR) has decided to ... Award for 2006 to Professor Anthony Blinkhorn ... University of Manchester. // ,Professor Blinkhorn ... field of public health and was even ...
... people in the UK are turning to smoking and alcohol ... mobiles and automated call centers, //according to a recent study. ... Partnerships (DPP). ,The DPP conducted a poll of ... problems were a major source of stress and 27% of ...
... live hepatitis A vaccine to India, as it has been ... export by the Zhejiang Pukang Biotech Co marks the debut ... has been tried on 130 million people in China and ... the disease by 20% every year in the past decade. ...
... Measles is reported to have broken out in the Indian ... ill. A senior police officer said two children at Sangarwani ... measles, a highly infectious disease that has assumed epidemic proportions ... and there is no healthcare available in Sangarwani, some residents ...
... South Africa which is capable of detecting the malaria parasites ... automatically collecting the blood samples //of the person who is ... it warns the person. Gervan Lubbe has developed the ... automatically penetrates the skin twice during the day and twice ...
... care will be approaching Indians living abroad to help the visually ... very high number// of visually impaired people, 80% of them can ... the age of 17 met with an accident that left her ... global ambassador for Sight Savers International. ,‘The purpose of ...
Cached Medicine News:Health News:More Britons Take To Alcohol Because Of Stress 2Health News:Debra Winger Wants Indians Abroad To Help Visually Impaired 2
(Date:12/19/2014)... KANSAS CITY, Kan. , Dec. 18, 2014 ... PETX ), a biopharmaceutical company focused on ... for companion animals, today announced positive results from ... company,s innovative drug for treating pain in dogs ... demonstrated improvements in pain assessment scores that were ...
(Date:12/17/2014)... STUTTGART, Germany , December 17, 2014 ... high level of expenditure on research and development ... ZEISS increased its revenue by two percent to EUR 4.287 ... Earnings (EBIT) grew by 14 percent to EUR 360 million. ... Group," said Dr. Michael Kaschke , President and CEO ...
(Date:12/17/2014)... , The new Dompé website aims ... the biopharmaceutical Group,s national and international clinical research activities ... launched institutional website that is receiving accolades from all over ... chapter in the fascinating story of Drug Discovery   , ... on the world of clinical research, ranging from information for ...
Breaking Medicine Technology:Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5ZEISS Asserts its Position in Difficult Environment 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3
Vertigraft femoral shaft an large femoral cross-section designed primarily for use in lumbar corpectomy procedures. Freeze dried preservation....
... stackable cage system provides anterior column support ... vertebrectomies from T1 to L5. The system ... fiber polymer cages that are stacked to ... The Peek Carbon fiber reinforced polymer material ...
... filler is an extrudable, moldable bone void filler ... use anywhere in the skeletal system, including extremities, ... serving as a temporary scaffolding for new bone ... on X-ray, making healing easier to assess. Boneplast ...
... Isotis obtained the CE mark for its ... has all the hallmarks of a smart material, ... in motion a cascade of events in the ... promises accelerated skeletal repair and improved fusion, and ...
Medicine Products: