Navigation Links
Early Trial Suggests COPD Drug Might Help Some Asthmatics
Date:9/20/2010

By Steven Reinberg
HealthDay Reporter

SUNDAY, Sept. 19 (HealthDay News) -- For asthma patients whose condition is not controlled with standard inhaled steroids, the addition of Spiriva -- a medication already approved for lung disease -- appears to improve breathing, a new study finds.

However, the study authors and an outside expert stressed that these are early findings and much longer, larger clinical trials are needed.

Tiotropium bromide (Spiriva)) belongs to a class of drugs called anticholinergics, which work by enlarging the airways to allow for easier breathing. Currently, the U.S. Food and Drug Administration has only approved the medication for use by patients with chronic obstructive pulmonary disease (COPD), a chronic ailment that is a combination of bronchitis and emphysema.

Treating asthma has never been a one-size-fits-all proposition, so "having a new class of asthma medications could be potentially important," said lead researcher Dr. Stephen P. Peters, a professor of pulmonary, critical care, allergy, and immunologic medicine at Wake Forest University, in Winston-Salem, NC.

"People are different. Some people will respond to some medications, some respond to others," he said.

The report, funded by the U.S. National Heart, Lung, and Blood Institute, is published in the Sept. 19 online edition of the New England Journal of Medicine. The journal is releasing the data early to coincide with its presentation Sunday at the European Respiratory Society meeting in Barcelona.

For the study, Peters' team tried three drug regimens on 210 asthmatics. These included: Spiriva plus an inhaled steroid; a double dose of the inhaled steroid; and an inhaled steroid plus Serevent, a long-acting beta agonist that relaxes the muscles in the airway.

Patients stayed on each regiment for 14 weeks.

The researchers found that Spiriva plus an inhaled steroid was more effective than giving a double dose of steroids in improving breathing and controlling asthma for these tough-to-treat patients.

In addition, the combination of an inhaled steroid and Spiriva was not less effective than using an inhaled steroid plus Serevent, they said.

That's important, Peters said, because there have been some safety concerns raised about long-acting beta agonists. These drugs carry a note on their labels warning of the possibility of severe adverse events, including death, he noted.

The results need to be confirmed in a much larger pool of patients, Peters said, and he noted that the patients were not followed long enough to see if Spiriva was able to reduce the severity of asthma attacks and hospitalizations.

In addition, Spiriva's safety profile among asthmatics still needs to be studied, he said.

Because the drug is not yet FDA-approved for use in asthma, Peters was reluctant to recommend it for that use. "My hope is that in three to five years we will have the drug approved for asthma," he said.

Dr. Shirin Shafazand, an assistant professor of pulmonary, critical care and sleep medicine at the University of Miami Miller School of Medicine, said that "perhaps there is a role for Spiriva in these poorly controlled asthmatics."

However, at this stage there is no definitive answer whether Spiriva should or shouldn't be used in asthma, she said.

"This is a good foundation to design a trial where you would look at Spiriva plus steroids versus doubling the dose of steroids in a large number of asthmatics who are poorly controlled and then you follow them long-term," Shafazand said, but right now there is no data on long-term efficacy and safety.

More information

For more information on asthma, visit the U.S. National Library of Medicine.

SOURCES: Stephen P. Peters, M.D., Ph.D., professor, pulmonary, critical care, allergy and immunologic medicine, Wake Forest University, Winston-Salem, N.C.; Shirin Shafazand, M.D., assistant professor, pulmonary, critical care and sleep medicine, University of Miami Miller School of Medicine; Sept. 19, 2010, New England Journal of Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Prostate cancer community calls for better early detection and treatment
2. Biomarkers May Aid in Early Diagnosis of Alzheimers
3. JCI online early table of contents: Sept. 13, 2010
4. Early prostate cancer detection, screening: No benefit for men with low baseline PSA value
5. Scientists make leap forward in early detection for Alzheimers and cancer
6. Combining medication and psychosocial treatments may benefit patients with early-stage schizophrenia
7. JCI online early table of contents: Sept. 1, 2010
8. Infants gaze may be an early, but subtle, marker for autism risk
9. In Early Trial, Targeted Therapy Fights Advanced Melanoma
10. Are early testing and drug development the most pressing issues in Alzheimers care?
11. Black women with SLE develop cardiovascular disease at early age
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Early Trial Suggests COPD Drug Might Help Some Asthmatics
(Date:6/20/2017)... ... 2017 , ... After months of negotiations, FaceCradle USA is proud to announce the debut of ... , “Introducing our product on QVC is something we all worked hard to achieve for ... more than 90 million homes in the United States,” said FaceCradle USA President Dylan Doherty. ...
(Date:6/20/2017)... ... 20, 2017 , ... Hayes, Inc., a leading provider of ... “ 5 Questions to Ask Before Entering the Maze of Genetic Testing .” ... (GTE) team, the book explores the various types of the more than 65,000 ...
(Date:6/20/2017)... , ... June 20, 2017 , ... Kenneth Mayer, MD, ... Society (JIAS). , Dr. Mayer, who joined the JIAS Editorial Board in 2016, ... founding Medical Research Director of Fenway Health and Co-Chair of The Fenway ...
(Date:6/20/2017)... ... June 20, 2017 , ... HOUSTON – Brazos Towers at Bayou ... host of new options for today’s modern senior. Brazos Towers at Bayou Manor has ... they love while offering them the services to support that lifestyle both now and ...
(Date:6/20/2017)... SAN DIEGO, California (PRWEB) , ... June 20, ... ... modern product documentation and help content solutions for the enterprise, is proud to ... web properties, including CRM, e-commerce, ticketing systems, company websites, and more to provide ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... Calif. , June 14, 2017 The ... the City of Fremont and ... of the bio-pharma industry in California ... technology, enabling executive networking, and fostering workforce development. The ... development and growth of start-ups, as well as small ...
(Date:6/12/2017)... , June 12, 2017 Kineta, Inc., a ... announced Kineta Vice President of R&D and Head ... the Pandemic Preparedness for the Northwest and Beyond ... held on June 14, 2017 from 8:30-10:30 AM PDT at ... Dr. Bedard will be joined by ...
(Date:6/9/2017)... AirXpanders, Inc. (ASX: AXP) (AirXpanders or Company), ... sale and distribution of the AeroForm® Tissue Expander System, ... commercial roll-out in the United States ... hundred (100) medical institutions and health systems, located throughout ... alternative for women who choose reconstructive surgery following a ...
Breaking Medicine Technology: