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Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology
Date:11/19/2007

Poster presentation highlights response rate in subset of patients with

Anaplastic Gliomas

NEW YORK, Nov. 19 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) today announced that early results of a phase II single agent trial of perifosine (KRX-0401) in patients with recurrent malignant gliomas was presented in a poster presentation on Saturday, November 17, 2007 at the 12th Annual Scientific Meeting of the Society for Neuro-Oncology, held in Dallas, Texas. The poster, entitled "A Phase II Trial of Perifosine for Recurrent/Progressive Malignant Gliomas, provided an update on the clinical activity of single agent perifosine in patients with malignant glioblastoma (GBM) and malignant anaplastic gliomas (AA).

Ph II Study - Interim Results

Twenty-five patients with advanced malignant gliomas were treated with a loading dose of 600 mg (150mg x 4) followed by 100 mg daily dose of perifosine. Patients must have failed prior radiation therapy and have shown unequivocal evidence for tumor progression by MRI or CT scan. There was no limitation on the number of prior relapses or prior therapies and patients with a KPS greater than or equal to 50 were eligible. Patients were not allowed to take enzyme-inducing anti-epileptic drugs (EIAED's). Response was measured by the MacDonald Criteria (PR greater than or equal to 50% decrease in bidirectional tumor area and SD = between 25% worse to 50% better). Patients were broken out into two groups with results as follows:

Malignant Glioma N Evaluable Partial Stable Overall (PR

Response Disease + SD)

All Patients 25 20
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SOURCE Keryx Biopharmaceuticals, Inc.
Copyright©2007 PR Newswire.
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