Navigation Links
Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology
Date:11/19/2007

Poster presentation highlights response rate in subset of patients with

Anaplastic Gliomas

NEW YORK, Nov. 19 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) today announced that early results of a phase II single agent trial of perifosine (KRX-0401) in patients with recurrent malignant gliomas was presented in a poster presentation on Saturday, November 17, 2007 at the 12th Annual Scientific Meeting of the Society for Neuro-Oncology, held in Dallas, Texas. The poster, entitled "A Phase II Trial of Perifosine for Recurrent/Progressive Malignant Gliomas, provided an update on the clinical activity of single agent perifosine in patients with malignant glioblastoma (GBM) and malignant anaplastic gliomas (AA).

Ph II Study - Interim Results

Twenty-five patients with advanced malignant gliomas were treated with a loading dose of 600 mg (150mg x 4) followed by 100 mg daily dose of perifosine. Patients must have failed prior radiation therapy and have shown unequivocal evidence for tumor progression by MRI or CT scan. There was no limitation on the number of prior relapses or prior therapies and patients with a KPS greater than or equal to 50 were eligible. Patients were not allowed to take enzyme-inducing anti-epileptic drugs (EIAED's). Response was measured by the MacDonald Criteria (PR greater than or equal to 50% decrease in bidirectional tumor area and SD = between 25% worse to 50% better). Patients were broken out into two groups with results as follows:

Malignant Glioma N Evaluable Partial Stable Overall (PR

Response Disease + SD)

All Patients 25 20
'/>"/>

SOURCE Keryx Biopharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Eye-staining technique offers early detection for dry eye syndrome
3. Early Weight Loss in Women Linked to Dementia
4. Isolation of a new gene family essential for early development
5. U of M study: Early treatment can reverse heart damage
6. Gerresheimer to be Included in the SDAX Early Decision on Inclusion in the MDAX on September 5, 2007
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Pop stars more than twice as likely to die an early death
9. Exercise and yoga improves quality of life in women with early-stage breast cancer
10. Research says doctors gender may hinder early diagnosis of heart disease in women
11. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... News) -- The quality of Americans, diets has improved ... the rich and poor is growing, a new study ... to date that the extensive efforts by many groups ... some payoff, but it also indicates that these efforts ... doctoral student in the department of nutrition at the ...
(Date:9/2/2014)... Amy Norton HealthDay Reporter , ... want to lose weight and boost their heart health, cutting ... a new study suggests. In a small clinical trial ... a low-carbohydrate diet lost more weight over a year than ... bigger improvements in their cholesterol and triglyceride levels, the research ...
(Date:9/2/2014)... Philadelphia, PA (PRWEB) September 02, 2014 ... Magee Rehabilitation Hospital returns on September 19 at The ... Hill, Pennsylvania. Over the past 25 years, the Classic, ... more than $12 million for programs and services designed ... at Magee Rehabilitation Hospital. , “The Segal Classic ...
(Date:9/2/2014)... 02, 2014 North America Resectoscopes ... Market Outlook to 2020? provides key market data ... provides value, in millions of US dollars, volume ... within market segments –,     Rigid ... Reusable) Electrodes and Bipolar (Disposable and Reusable) Electrodes). ...
(Date:9/2/2014)... 02, 2014 Humility of Mary Health Partners ... at St. Elizabeth Health Center, 1044 Belmont Ave. , The ... more than 200 common health problems as well as tips ... injury, and advice on when to seek medical attention. ... in the Youngstown Room; the evening session runs from 5:30 ...
Breaking Medicine News(10 mins):Health News:Quality of U.S. Diet Improves, Slightly 2Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 2Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 3Health News:The 25th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 3Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 4Health News:HMHP Offers ‘Health at Home’ Workshop 2
... of the Johns Hopkins Children,s Center and Scott Sicherer of ... caution when ordering allergy tests and to avoid making a ... article, published in the January issue of Pediatrics , ... tool in recent years, and skin-prick testing, an older weapon ...
... Doheny HealthDay Reporter , FRIDAY, Dec. 23 (HealthDay ... imaging tests between diagnosis and surgery than they did in ... -- breast ultrasounds, MRIs and mammograms -- help doctors determine ... hassles and expense of care, the study says. ...
... News) -- Reindeer have lots to do this time of ... sleighs -- but despite all their frenzied activity they manage ... overheated, researchers have found. Now, Norwegian scientists have gained ... of reindeer as they exercised on solid ground. In ...
... 23 (HealthDay News) -- Obese people who have had surgery to ... of the disease or die from cancer within five years as ... the study, published in the Dec. 1 issue of the ... Rochester, Minn., suggested their findings could change the way some doctors ...
... FRIDAY, Dec. 23 (HealthDay News) -- The holiday season can ... take steps to ensure they stay healthy through this often ... is a cancer survivor and their ranks are growing. Many ... disease and its treatment, experts at the Fred Hutchinson ...
... , FRIDAY, Dec. 23 (HealthDay News) -- Parents of ... lifestyle changes that will benefits their kids, health, a ... efforts to combat the childhood obesity epidemic among Hispanic ... United States, said the researchers at University of Texas ...
Cached Medicine News:Health News:Memo to pediatricians: Allergy tests are no magic bullets for diagnosis 2Health News:Memo to pediatricians: Allergy tests are no magic bullets for diagnosis 3Health News:Breast Cancer Patients Face More Imaging Tests Today 2Health News:Breast Cancer Patients Face More Imaging Tests Today 3Health News:Study Shows How Busy Reindeer Keep Their Cool 2Health News:Obesity Linked to Higher Esophageal Cancer Death Rates 2Health News:Cancer Survivors Should Take Steps to Keep Healthy During Holidays 2Health News:Parents May Hold Key to Healthy Weight in Hispanic Kids 2
(Date:9/2/2014)... 2, 2014  VentiRx Pharmaceuticals, Inc., a ... development and commercialization of novel Toll-like receptor ... U.S. Food and Drug Administration (FDA) has ... of motolimod (VTX-2337) when administered in combination ... treatment of women with ovarian cancer whose ...
(Date:9/2/2014)... , Sept. 2, 2014 Bluegrass ... company focused on innovating lifesaving devices and methods ... of Dr. Gabriele Niederauer , a seasoned ... Following the recent closure of Series A financing, ... the Surfacer™ Inside-Out Access Catheter System, a proprietary ...
(Date:9/2/2014)... LAUSANNE , Switzerland , ... after receiving ISO 13485 accreditation, Sophia Genetics has become ... mark for the clinical use of a Next Generation Sequencing ... assurance certification represents an important step in raising ... diagnosis, and brings Sophia Genetics, world-leading Data Driven ...
Breaking Medicine Technology:VentiRx Pharmaceuticals Announces Fast Track Designation Granted for Motolimod (VTX-2337), a Novel Immunotherapy for Women with Ovarian Cancer 2VentiRx Pharmaceuticals Announces Fast Track Designation Granted for Motolimod (VTX-2337), a Novel Immunotherapy for Women with Ovarian Cancer 3Bluegrass Vascular Technologies Names Dr. Gabriele Niederauer President And CEO 2Sophia Genetics Becomes the First European Company to Obtain CE-IVD Mark for Clinical use of Next Generation Sequencing Bioinformatics Pipeline for Routine Genetic Testing 2
... 20 The District of Columbia Patients, Cooperative ... the District of Columbia, has submitted comments to the ... on proposed regulations announced 45 days ago.   ... http://www.dcpatients.org/DCPC_comments.pdf along with the comments of cannabis ...
... NewBridge Pharmaceuticals FZ-LLC of Dubai, UAE announced today that ... Executive Officer and a member of the company,s Board ... joins NewBridge after a career extending over 29 years ... positions covering many geographies including; US, Europe, and Middle ...
Cached Medicine Technology:DC Patients' Cooperative Urges Changes to the Proposed Medical Cannabis 'Marijuana' Regulations 2NewBridge Pharmaceuticals Completes $12 Million First Close of Series B Financing, Announces Senior Executive Appointments 2NewBridge Pharmaceuticals Completes $12 Million First Close of Series B Financing, Announces Senior Executive Appointments 3
All welded construction for strength and durability. Choice of stainless steel or chrome plated models. One forward leg with caster for increased mobility....
All welded construction for strength and durability. Choice of stainless steel or chrome plated models....
All welded construction for strength and durability. Choice of stainless steel or chrome plated models....
Ideal for surgical procedures, these portable stands fit into tight areas for easy instrument access. Designed for limited space environments. Adjustable height for comfortable use while sitting or s...
Medicine Products: