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Early Detection of Melanoma Plus Regular Skin Exams is Vital For Beating Disease
Date:5/4/2009

ure to remove the tumor and a margin of normal-looking skin around it is performed and neither chemotherapy nor radiation is required.

In special circumstances where a melanoma occurs on a cosmetically or functionally critical site, such as the lip, nose, eyelid or finger, Dr. Rogers noted that a new technology based on a variation of Mohs surgery is being used successfully. The procedure uses an anti-melanoma targeted antibody known as MART-1 (Melanoma Antigen Recognized by T cells), which improves the speed and accuracy of the procedure. The technique allows the surgeon to microscopically identify and remove the melanoma cells with minimal sacrifice of healthy tissues in real-time (16-20 minutes). The ability to successfully resect (or surgically remove) the cancer with potentially an 1/8 inch margin rather than an inch margin is critical when working on delicate structures such as an eyelid, said Rogers.

For stage II melanomas, surgery is performed to remove the tumor and surrounding tissue. In addition, the dermatologic surgeon often tests the lymph nodes to determine if the cancer has spread. If the melanoma is going to spread, Dr. Rogers noted that 57 percent of the time the first place the cancer goes is to the local draining lymph nodes. A procedure known as a sentinel lymph node biopsy tests the first lymph nodes into which the melanoma drains. If the lymph nodes are free of cancer cells, then the melanoma is considered in stage II with an average five-year survival rate of 70 percent. In this stage, Dr. Rogers explained that interferon may be given as an adjuvant (or drug-enhancing agent) to boost the patient's immune system.

However, if the lymph nodes are determined to be involved, then the melanoma is classified as stage III. In this stage, the cancer has spread to one or more nearby lymph nod
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SOURCE American Academy of Dermatology
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