Navigation Links
Earlier treatment for young patients with chronic hepatitis B more effective in clearing virus
Date:9/6/2012

Scientists from A*STAR's Singapore Institute for Clinical Sciences (SICS), together with clinical collaborators from London , discovered for the first time that children and young patients with chronic Hepatitis B Virus infection (HBV carriers) do have a protective immune response, contrary to current belief, and hence can be more suitable treatment candidates than previously considered.

This discovery by the team of scientists led by Professor Antonio Bertoletti, programme director and research director of the infection and immunity programme at SICS, could lead to a paradigm shift in the current treatment of patients with chronic HBV. The findings were published in Gastroenterology on 1st September.

Current guidelines from international liver associations recommend delaying therapy until HBV carriers show clear signs of active liver disease, which generally appear after the age of 30 . This is based on two assumptions. One, young patients are unable to react to treatment because they are immune-tolerant to the virus. This means that there is no protective immune response in their body to help them get rid of the virus, and therefore, they will not run the risk of liver damage or inflammation. Two, HBV infection is largely harmless in HBV carriers until active liver disease is apparent.

However, Professor Bertoletti and his team showed that young patients are not immune tolerant as they posses HBV-specific T cells with the ability to produce distinct antiviral cytokines that help the body fight against HBV. They also showed that the longer a patient is left untreated, the less effective their immune system becomes against HBV and the less able the patient will be able to clear the virus from their body even when they receive treatment.

The scientists demonstrated that the presence of HBV in the body over a long period of time is harmful to the patient due to repeated activation of T-cells which induces a progressi
'/>"/>

Contact: Siok Ming Ong
ong_siok_ming@a-star.edu.sg
65-682-66254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Obesitys Health Costs Double Earlier Estimates
2. New biomarker test predicts arthritis at much earlier stage, MU researchers say
3. Advanced Prostate Cancer Drug May Help at Earlier Stage
4. Middle-Aged Diabetics May Need Earlier Colon Checks
5. Super-sensitive tests could detect diseases earlier
6. New traffic light test could save lives with earlier diagnosis of liver disease
7. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
8. Clinical insight improves treatment with new lung cancer drug
9. Rapid Asthma Treatment in ER May Prevent Admission
10. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
11. Breast cancer patients suffer treatment-related side effects long after completing care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 Today, Zane Benefits, the #1 ... Account-Based Health Plans. , According to Zane Benefits, employers ... to lower the cost of healthcare without reducing coverage ... accounts, however, can be confusing. , The new guide ... four main types of ABHPs. It also explains ...
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... affordable email marketing services that currently helps more ... marketing efforts has caught the attention of Shane Michaels, ... a still a crucial element for any online marketing ... media replacing email in the marketing world,” reports Michaels. ...
(Date:8/22/2014)... 2014 Top 10 Best SEO ... hosting companies and highly recommended FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ... manager of Top 10 Best SEO Hosting states, ... server hosting supplier. Actually, these companies have outperformed ... and customer support. People can get the best ...
(Date:8/22/2014)... NV (PRWEB) August 22, 2014 ... that is written by marketing experts for marketers to ... links has caught the attention of Shane Michaels, prompting ... with Internet marketing in any way knows that content ... in the industry,” reports Michaels. “But even though content ...
(Date:8/22/2014)... (PRWEB) August 23, 2014 Recently, UWDress.com, a ... outfits, has added a new range of empire bridesmaid ... the company has launched a summer promotion for these high ... discounted rates, from 25 to 75 percent off. , ... ladies. Also, UWDress.com offers efficient assistance on its website. It ...
Breaking Medicine News(10 mins):Health News:AWeber: Review Exposes Affordable Provider of Opt-In Email Marketing Services 2Health News:FatCow Reviews Released by Top10BestSEOHosting.com 2Health News:My Writers: Review Exposes Online Source for Quality Marketing Content 2Health News:Discounted Empire Bridesmaid Dresses Online At UWDress.com 2
... is widespread disgust and outrage expressed over the housing together ... Sebastian Wheeler, 43, and his boyfriend Victor Leslie Urquhart, ... Australia. ,The two men were convicted ... him for 20 days, before he was rescued. The pair ...
... tuberculosis, researchers say. ,A study of 131 people found ... to inhibit the growth of the bacteria causing the disease, reported ... has evaluated the effect of Vitamin D on the body's immunity ... researchers took blood from all the participants and infected with mycobacteria. ...
... Low-income African-American high school students with asthma who ... reported fewer days and nights with symptoms, ... activity, and less hospitalization for asthma during a ... students. ,Christine L. M. Joseph, M.P.H, ...
... At least eight people have died due to sunstroke in ... ,While three deaths have been reported from the ... from the districts of Balasore, Kandhamal, Kendrapada, Nuapada and Sundergarh, ... told IANS. ,We received complaints of about 53 ...
... not that killer body that the opposite sex takes into account ... if you are a man. ,To find our ... from the University of Western Australia in Crawley led by Marianne ... photographs. ,The volunteers were asked to rate attractiveness on ...
... that Alzheimers drug Donepezil may help people who have ... Berthier of the M dico-Sanitarias Research Centre in Malaga, ... ability to communicate. ,The researchers wanted to ... a condition characterised by an inability to pronounce or ...
Cached Medicine News:Health News:Outrage Against Gay PartnersInCrime Kept Together 2Health News:Web-based Asthma Program Improves Disease Management for Black Students 2
(Date:8/22/2014)... 22, 2014  Medical Science Liaisons serve as a ... the healthcare sector. As the impact of technology in ... how Medical Science Liaisons (MSLs) interact with physicians and ... the tablet to not only share important disease and ... thought leader interactions across geographies and therapeutic areas. ...
(Date:8/22/2014)... 22, 2014 ... has announced the addition of the  "Global ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... instrument for any modern science laboratory as ... materials. It can be broadly classified into ...
(Date:8/22/2014)... Research and Markets ( ... the  "Global Operating Room Equipment Market 2014-2018" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,An operating room is ... a healthcare facility used to perform surgical ... equipment, which ensures patient care and enhanced ...
Breaking Medicine Technology:iPads Enhancing Medical Science Liaison Interactions with Thought Leaders, New Study Shows 2Global Laboratory Electronic Balance Market 2014-2018: Key Vendors are A&D Company, Mettler-Toledo, Sartorius and Thermo Fisher 2Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2
... June 13 Telmisartan, an angiotensin receptor blocker, ... been studied in clinical trials in more than 50,000 patients. ... market exposure of 34.5 million patient years. Convincing safety data ... the three long-term outcome trials ONTARGET, PRoFESS and TRANSCEND which ...
... Scientists from the Barbara Ann Karmanos Cancer Institute in ... agents used to promote bone health and inhibit resorption, may ... early stage breast cancer who take them for their anti-osteoporosis ... Society of Clinical Oncology Annual Meeting. , ...
Cached Medicine Technology:Boehringer Ingelheim Affirms Safety of Telmisartan With an Analysis of 50,000 Patients and Strongly Disagrees With the Publication of Sipahi et al in Lancet Oncology June 2010 2Boehringer Ingelheim Affirms Safety of Telmisartan With an Analysis of 50,000 Patients and Strongly Disagrees With the Publication of Sipahi et al in Lancet Oncology June 2010 3Boehringer Ingelheim Affirms Safety of Telmisartan With an Analysis of 50,000 Patients and Strongly Disagrees With the Publication of Sipahi et al in Lancet Oncology June 2010 4Boehringer Ingelheim Affirms Safety of Telmisartan With an Analysis of 50,000 Patients and Strongly Disagrees With the Publication of Sipahi et al in Lancet Oncology June 2010 5Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer 2Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer 3Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer 4
... Crossover system of implants and instruments provides ... posterior rod construct in the thoracic and ... system are available in three size ranges: ... can be used with the Isola, Pediatric ...
Portable ultrasound doppler system for peripheral and transcranial investigation....
Multiwindow transcranial and peripheral Doppler system....
Bi-Directional doppler volume flowmeter....
Medicine Products: