Navigation Links
Earlier HIV Treatment Could Save Lives Worldwide

Study looks at costs and benefits of revising treatment guidelines

MONDAY, July 20 (HealthDay News) -- Beginning antiretroviral therapy soon after an HIV diagnosis should be standard care for all, including those in poor nations where cost is a barrier, new research contends.

An estimated 76,000 deaths could be prevented and 66,000 infections avoided over a five-year period, the researchers say, if antiretroviral therapy (ART) were started when CD4 T-cell levels drop below 350 per microliter of blood instead of delaying until levels fall below 250. Their study is reported in the Aug. 4 issue of Annals of Internal Medicine.

"The time has come to act on the information we now have, nearly all of which supports starting treatment earlier," said study co-author Robin Wood, director of the Desmond Tutu HIV Centre at the University of Cape Town in South Africa, in a news release about the study. South Africa currently has the highest rates of HIV infection in the world.

Because ART is expensive and can have significant side effects, World Health Organization treatment guidelines issued in 2006 suggested waiting until CD4 counts drop below 200 per microliter of blood or until people developed AIDS-related complications. The CD4 count reflects immune system function.

In developed nations, including the United States, ART is typically started when the CD4 count drops below 350, according to the study. Applying a similar standard in countries with limited financial resources would save lives and be cost effective, the researchers say.

The study estimated the cost at $1,200 per year of life saved.

"While those standards accommodate the limited resources and short supply of medications in many settings, the greater prevalence of tuberculosis and other opportunistic infections in places like South Africa argue for earlier treatment initiation, even before the results of ongoing clinical trials are known," said the study's lead author, Dr. Rochelle Walensky, of the division of infectious disease at Massachusetts General Hospital in Boston.

The researchers used mathematical modeling to simulate HIV treatment and calculate the possible health and economic outcomes. The model determined the additional costs of earlier treatment, potential toxicities and benefits. It also looked at the cost-effectiveness of earlier ART initiation.

More information

The U.S. Centers for Disease Control and Prevention has more on HIV/AIDS.

-- Jennifer Thomas

SOURCE: Massachusetts General Hospital, news release, July 20, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Earlier Testing Needed for Fragile X Syndrome
2. Signs of Alzheimers Seen Earlier Than Thought
3. Chemical Nose May Sniff Out Cancer Earlier
4. Clues to Alzheimers Spotted Earlier in Disease
5. Underweight and extremely obese die earlier than people of normal weight, study finds
6. Underweight and Extremely Obese Die Earlier Than People of Normal Weight, Study Finds
7. Cerebrospinal fluid shows Alzheimers disease deterioration much earlier
8. Immune Defense - the Earlier, the Better: Expert Cites Supplement from Pure Research Products
9. Diagnosis of arthritis 5 years earlier in childless women compared to those with children
10. Viewing Adult-Themed TV Tied to Earlier Sex for Teens
11. Children who view adult-targeted TV may become sexually active earlier in life
Post Your Comments:
Related Image:
Earlier HIV Treatment Could Save Lives Worldwide
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... edge technology to revolutionize the emergency ambulance transport experience for the millions of ... of how Uber has disrupted the taxi industry through the use of technology. ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: