EURYI project to understand how the brain wires during emb... (king two key centres the thalamus which ...)

EURYI project to understand how the brain wires during embryogenesis

Date:9/21/2007

king two key centres, the thalamus, which relays external sensory information, and the cerebral cortex, the most highly developed region comprising the so-called grey matter.

The thalamocortical projections, that first appeared in reptiles, have been remodelled in rodents and in primates, and are therefore of great interest in the study of neurological evolution. This phase of accelerated changes in connections correlates with an increase in cell migration in the brain. But there was a price to pay for this sophistication in the form of disorders associated with neurological dysfunctions, which particularly afflict humans. Garel hopes that her work will also advance understanding of some of these disorders, which can arise through defects both in the network of axonal connections and in the process of cell migration.

Understanding how neural circuits are elaborated during mammalian forebrain development is essential to gain insights into its normal functioning and to make progress in our comprehension of neurological and psychiatric disorders, said Garel. But malfunctions in cell migration can be just as harmful. During development, cell migration is essential to control the positioning of cells in the brain, and cell migration defects have been associated with several neuropsychiatry diseases such as epilepsy, schizophrenia or bipolar disorders, said Garel.

Garel will conduct her research in mice, aiming to improve understanding of how cell migration and axonal circuit development fit together. We have showed that, in mice embryos, migrating cells act as dynamic guideposts to guide growing axons towards their final target in the brain, said Garel. Our study thus opens a novel perspective of the role of cell migration in the formation of brain connections during normal and pathological development.

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Contact: Thomas Lau
tlau@esf.org
33-388-762-158
European Science Foundation
Source:Eurekalert

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