Navigation Links
EURYI project to understand how the brain wires during embryogenesis
Date:9/21/2007

One of the great questions of neurobiology, how the brain is built up during embryonic development, could be resolved by a young French scientist in an award winning project organised by the European Science Foundation (ESF) and the European Heads of Research Councils (EuroHORCS). Sonia Garel has won one of the prestigious EURYI Awards granted annually to young scientists, to pursue her ground breaking research into mammalian forebrain development. She will tackle a number of fundamental questions relating both to the wiring of the brain during growth, and how evolution drove forward the sophisticated neural circuitry associated with mammals.

Garel will focus on two key processes involved in development of neural circuitry in the forebrains of young mammals as they grow. One of these processes concerns the formation of connections between neurons, the nerve cells of the brain. These connections are needed to process sensory information, execute motor functions, and provide the network for cognitive abilities. They are made up of nerve fibres called axons, which conduct electrical impulses between neurons. The other key process involves migration of brain cells to their correct positions after their manufacture. As Garel noted, these two processes are coordinated in the development of the mammalian brain, and yet have until now been studied separately for the sake of simplicity. Garel and her colleagues have already broken new ground by demonstrating the link between axon formation, and migration of cells, within the brain.

While axon guidance and cell migration have been usually studied as independent processes, our group has shown for the first time that they are elegantly coordinated to ensure the formation of a major long-range connection of the mammalian brain, the thalamocortical projection, said Garel. The thalamocortical projection is one of the significant evolutionary developments of the forebrain, comprising bundles of axonal connections linking two key centres, the thalamus, which relays external sensory information, and the cerebral cortex, the most highly developed region comprising the so-called grey matter.

The thalamocortical projections, that first appeared in reptiles, have been remodelled in rodents and in primates, and are therefore of great interest in the study of neurological evolution. This phase of accelerated changes in connections correlates with an increase in cell migration in the brain. But there was a price to pay for this sophistication in the form of disorders associated with neurological dysfunctions, which particularly afflict humans. Garel hopes that her work will also advance understanding of some of these disorders, which can arise through defects both in the network of axonal connections and in the process of cell migration.

Understanding how neural circuits are elaborated during mammalian forebrain development is essential to gain insights into its normal functioning and to make progress in our comprehension of neurological and psychiatric disorders, said Garel. But malfunctions in cell migration can be just as harmful. During development, cell migration is essential to control the positioning of cells in the brain, and cell migration defects have been associated with several neuropsychiatry diseases such as epilepsy, schizophrenia or bipolar disorders, said Garel.

Garel will conduct her research in mice, aiming to improve understanding of how cell migration and axonal circuit development fit together. We have showed that, in mice embryos, migrating cells act as dynamic guideposts to guide growing axons towards their final target in the brain, said Garel. Our study thus opens a novel perspective of the role of cell migration in the formation of brain connections during normal and pathological development.


'/>"/>

Contact: Thomas Lau
tlau@esf.org
33-388-762-158
European Science Foundation
Source:Eurekalert

Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. Race Based Genome Project Launched By Mexico
3. Pink Shawl Project is a unique initiative
4. Telemedicine Project Implemented for Indian Railways
5. UNAIDS Chief Appeals for Projects to Battle AIDS/HIV
6. DAPIC Project to Prevent Amputations
7. Indias vaccination project gets a boost
8. 3-D Projection Of Heart For Diagnosis Of Cardiovascular Disorders
9. Canadian Sikh Community Donates To Hospital Project In Canada
10. The “Enough Sleep” Project to study mechanism of sleep regulatin
11. NIH To Launch Two Major Gene and Disease Projects Soon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... On ... holding a treadmill relay – Miles by Moonlight to raise money for the American ... $300 or more. , Teams will work together to keep their treadmills moving ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... Labs announces the European launch of their new low volume, high ... in Cambridge, U.K on October 4th. The ... with unprecedented speed and sensitivity while using far less sample volume ... ... ...
Breaking Medicine Technology: