Navigation Links
ESC calls for research into vulnerable plaques
Date:6/14/2011

Sophia Antipolis, France: Tuesday 14 June : The European Society of Cardiology (ESC) Working Group of Atherosclerosis and Vascular Biology has published a position paper to raise the profile of vulnerable plaques and the need for greater use of therapies to promote plaque stabilisation. The position paper, published online today in Thrombosis and Haemostasis, is also calling for more research into the causes of plaque rupture, and for the development of better diagnostics and treatments.

"We want more medical professionals to understand the concept that stabilising vulnerable plaques offers a fundamental approach to preventing cardiovascular events," said Seppo Yl-Herttuala, chairman of the position paper task force. Indeed, he added, several statin trials for secondary prevention have reported a reduction in cardiovascular events, and furthermore anti platelet therapies have been shown to have a beneficial effect.

"Introducing stabilisation of vulnerable plaques as part of secondary prevention would offer the opportunity to wipe out half of coronary events," said Yl-Herttuala, from University of Eastern Finland (Kuopio, Finland).

"Wide spread stabilization of vulnerable plaques would also have important socio economic implications dramatically reducing the need for invasive treatments," said Christian Weber, also a member of the working group.

The idea of vulnerable plaques is that not all plaques (the fatty deposits in arterial walls) are equal and that some are particularly prone to rupture and causing cardiovascular events . These plaques are not necessarily the same as those that cause symptoms such as angina. Explaining the concept of vulnerable plaques, Weber, from Ludwig-Maximilians-University (Munich, Germany) said that it is thought that inflammatory cells resulting from ongoing inflammation destabilise the structure of the plaque. "It is believed that they degrade the fibres that make the plaque stable, leading to a greater potential for the plaque to rupture," he said.

The concept of plaque stabilisation was introduced to explain how acute coronary events could be reduced by lipid lowering therapy without accompanying regression of coronary atherosclerosis seen on angiography.

Part of the motivation for producing the working paper, said Yl-Herttuala, was to provide general clinicians with greater guidance. "The whole field can be really confusing. After patients have been treated with statins for two or three years family doctors can be really concerned that they see no changes on angiograms. In such cases there's a danger that they may decide to stop life saving treatment."

The position paper reviewed the current state of knowledge around unstable plaques exploring the role of inflammation, chemokines, growth factors, platelets, angiogenesis and smoking. Evidence for therapies such as statins, antiplatelet therapies, and antihypertensive treatments were outlined, in addition to reviewing new approaches ,such as the development of drugs targeting the fibrous cap. Detection of unstable plaques through genetic testing, biomarkers and imaging was also explored.

"The single most important advance that would help us to tackle vulnerable plaques would be to have a non invasive imaging tool that would allow us to identify at risk patients before they suffer an event," said Yl-Herttuala.

The position paper is also calling for more translational research into imaging, biomarkers and the development of new treatments. "There is a real need to develop treatments specifically for the purpose of stabilising vulnerable plaques. At the moment we only have treatments that were discovered to have a beneficial effect through serendipity," said Weber.


'/>"/>

Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Forecast calls for nanoflowers to help return eyesight
2. CMAJ calls on federal government to protect Canadians from unsafe drugs
3. Report Blames Speedy FDA Clearance for Medical Device Recalls
4. Calls Go Out to Revive the Traditional Physical
5. Tufts University calls for moderate approach to teaching personalized genomic testing
6. FDA Panel Calls for Safety Review of Mercury in Dental Fillings
7. FDA Calls for New Warnings on Some Prostate Cancer Drugs
8. International Menopause Society calls upon medical community to improve the vaginal health of postmenopausal women
9. European Nurse Society calls to action on breakthrough cancer pain
10. Prostate cancer community calls for better early detection and treatment
11. IAS calls for an end to harassment, intimidation and imprisonment of HIV professionals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... The Karen Miller Agency, a ... in the greater Birmingham area, is joining the Chris Hammond Youth Foundation in ... the region. , The Chris Hammond Youth Foundation maintains athletic facilities in rural ...
(Date:7/21/2017)... ... July 21, 2017 , ... Thomas Jefferson University ... , was awarded a $300,000 grant from The Pew Center for Arts & ... ambiguity and the recognition of one’s own limits among health professions students. ...
(Date:7/21/2017)... ... 21, 2017 , ... The Margarian Law Firm has filed a class ... ale for allegedly containing no ginger. Dr. Pepper produces the “Canada Dry” brand of ... Margaryan alleges Canada Dry Ginger Ale claims on its bottle that it is made ...
(Date:7/21/2017)... ... July 21, 2017 , ... MedMatchPlus+ has ... chances of acceptance to a residency in a United States hospital. Being accepted ... the U.S. , According to data released by the ECFMG®, every year, 50 ...
(Date:7/21/2017)... ... July 21, 2017 , ... West Dermatology is pleased to announce the ... July 17, 2017, Ms. Vu will join West Dermatology’s large network of medical and ... skin cancer , and more. She graduated from the University of Florida College ...
Breaking Medicine News(10 mins):
(Date:7/19/2017)... 19, 2017  Mako Medical Laboratories partnered with Secretary ... Family Assistance Fund (MFA) to bring 140 soldiers back ... with their families one last time before being deployed. ... travel and logistics needed for these soldiers. "Mako Medical ... their families. We just wish we could bring them ...
(Date:7/14/2017)... 13, 2017 It should come as no surprise ... is in the midst of a crippling opioid epidemic. According ... the number of overdose deaths from opiate-based medications has quadrupled, ... a million dead from 2001 to 2015". During this time, ... has similarly quadrupled, drawing a compelling link between prescription and ...
(Date:7/12/2017)... , July 12, 2017 CarpalAID is a revolutionary ... braces or surgery. Carpal tunnel syndrome affects more than ... at twice the rate of men. The common methods of treating ... mobilization with uncomfortable hand braces or gloves. ... CarpalAID is a clear patch ...
Breaking Medicine Technology: