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EPC secreted factors favorably impact on pancreatic islet cell cotransplantation
Date:11/25/2013

Putnam Valley, NY. (Nov. 25 2013) Pancreatic islet transplantation is a promising therapy for treating type 1 diabetes, but the majority of transplanted cells die soon after they are transplanted. Researchers interested in prolonging the life of these cells co-transplanted endothelial progenitor cells (EPCs) along with pancreatic islet cells and found that the EPCs improved the engraftment of pancreatic islet cells in mouse models, thereby favorably impacting on the cure rate and glycemic control of transplanted islets. The study will be published in a future issue of Cell Transplantation but is currently freely available on-line as an unedited early e-pub at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-CT1021Penko

"EPCs are a promising candidate for improving outcomes in islet transplantation and their mechanisms warrant further study," said study co-author Dr. Claire Jessup of the Department of Human Physiology at the Flinders University School of Medicine in Bedford Park, Australia. "Our study indicates that EPCs or their soluble products modulate the expression of the beta cell surface molecule connexion 36 and affect glucose-stimulated insulin release."

According to the researchers, EPCs are a circulating bone-marrow cell that are able to home to sites of damaged tissue or ischemia and can participate in wound healing and rebuilding blood vessels, especially after translantation. Although EPCs have the ability to integrate into newly growing blood vessels, they can also provide humoral factors (elements in blood or other fluids) that may "recruit" other cells to impact favorably on vascular remodeling. This study planned on exploring how EPCs secreted humoral factors and how those factors may impact pancreatic islet cell gene expression and function and thus aid islet cell survival following tramnsplantat
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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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