Navigation Links
EORTC study identifies patients with anaplastic oligodendroglioma that benefit from adjuvant PCV
Date:5/29/2013

A further report on the results of EORTC trial 26951 indicates that CpG island methylator phenotype (CIMP) status and O 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation as assessed by MGMT-STP27 are the most informative for identifying grade III glioma patients who might benefit from the addition of procarbazine, CCNU and vincristine (PCV) chemotherapy to radiation therapy. Prior results had shown that PCV chemotherapy following standard radiation therapy delayed tumor growth and extended the lives of patients with anaplastic oligodendroglial tumors, a hard-to-treat form of brain cancer.

Results observed in the phase III RTOG 9402 trial, in this case with chemotherapy preceding radiation therapy, complemented the results obtained previously in the EORTC 26951 trial and found that administering both PCV and radiation therapy led to comparable improvements in survival for oligodendroglial tumor patients with specific deletions of genetic material in chromosomes 1p and 19q, but not for patients without the mutation.

Nevertheless up to 30% of oligodendroglial tumors do not have 1p/19q deletion but may still respond to chemotherapy. Analyses of EORTC 26951 and RTOG 9402 suggested that other molecularly defined subsets of grade III tumors might benefit as well.

The new results will be presented at an ASCO 2013 Clinical Science Symposia on Sunday, 02 June 2013 by Dr. Martin J. Van Den Bent of the Erasmus Medical Centre Cancer Institute, Rotterdam, The Netherlands, and coordinator of the study. According to Dr. Van Den Bent, "This is further evidence pointing towards a central role of methylation in the behavior of IDH (isocitrate dehydrogenase) mutated glioma and, more in general, of the MGMT gene function in glioma when treated with chemotherapy."

Methylation profiles of 115 patients were conducted using Infinium HumanMethylation27 or Infinium HumanMethylation450 BeadChip kits. (Validation in an independent dataset is required.)

In these analyses, two markers, CIMP and MGMT-STP27 methylation status, were considered promising in being able to differentiate between patients who will and will not respond to PCV chemotherapy. Two other markers, IDH mutation status and 1p/19 chromosomal deletion, had less strength in achieving this differentiation.

The EORTC 26951 intergroup trial was coordinated by the EORTC Brain Tumor Group in collaboration with the Medical Research Council Clinical Trial Unit and supported by Stichting STOPhersentumor.nl. This academic trial was activated in August 1996, closed in March 2002, and included 368 patients in 40 sites in 10 countries: Austria, Belgium, Finland, France, Germany, Hungary, Italy, Sweden, The Netherlands, and the United Kingdom.


'/>"/>

Contact: John Bean
john.bean@eortc.be
32-277-41671
European Organisation for Research and Treatment of Cancer
Source:Eurekalert

Related medicine news :

1. EORTC led intergroup trial investigates Imatinib failure-free survival in patients with GIST
2. Media alert: 24th EORTC - NCI - AACR Symposium Molecular Targets and Cancer Therapeutics
3. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Offer New Guided Weight Loss Tips Now Found in New Study to Help Patients Lose Weight Fast
4. A Strong Marriage Can Shield Kids From Dads Depression: Study
5. Narconon Releases Early Study of Delaware Prison Program, Demonstrating Crime Reduction Consistent with More Recent Narconon Results
6. Changing gut bacteria through diet affects brain function, UCLA study shows
7. GOJO presents electronic hand hygiene compliance study at APIC conference
8. Alzheimers Patients Mimic Emotions of Those Around Them: Study
9. Study: Ipilimumab Shows Durable Responses But Low Overall Response Rate In Patients With Unresectable Or Metastatic Mucosal Melanoma
10. Kids Poisoned by Medical Marijuana, Study Finds
11. Involving Patients in Decisions Raises Health Care Costs, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... Barcelona, Spain (PRWEB) , ... September 26, 2017 ... ... exciting nutritional ingredient that is not only entirely new and different, it is ... extracts, announced today that the company has received an exclusive license agreement with ...
(Date:9/26/2017)... ... September 26, 2017 , ... Data Integrity: , The ... **, Dec. 5-6, 2017 – Arlington, VA, http://www.fdanews.com/fdadataintegrity , ... indicate the firm’s electronic records may not be trustworthy and reliable … a more ...
(Date:9/26/2017)... ... September 26, 2017 , ... The 2017 American Academy ... “The Magic of Fat,” revealed not only the latest about cosmetic procedures to remove ... an evolution in cosmetic medicine. , “Fat really is magical, especially when it comes ...
(Date:9/26/2017)... ... ... “Good Morning Sunshine!: Finding Strength and Comfort in God”: a hopeful and ... Comfort in God” is the creation of published author, Terri Braun, a mother of ... at a local mental health center for over twenty years, helping the severely and ...
(Date:9/26/2017)... ... September 26, 2017 , ... “Sonflower Submission”: a relatable and concise reality ... destinations of negativity, complaining and the need to always be correct. There comes a ... for a lesson in stress-less living to be learned. “Sonflower Submission” is the ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/19/2017)... Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses ... today:   ... Jim ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D and business ...
Breaking Medicine Technology: