Navigation Links
ENERCA clinical recommendations for sickle cell disease management and prevention in children

ENERCA is a European Network for Rare and Congenital Anaemias funded by the European Commission and coordinated by IDIBAPS - Hospital Clnic of Barcelona. Its main purpose is offering an improved public health service to medical practitioners and patients in every aspect of rare anaemias. Recently this year this network published in the American Journal of Hematology (AJH) a series of recommendations for disease management and prevention of complications of sickle cell disease (SCD) in children. With this of publication ENERCA is willing to give clinical guidance to professional medical practitioners through medical literature.

The article is divided in three main issues: Prevention of complications, treatment and therapies for acute disease. Different aspects of each issue are exposed through the text, including the recommendations and historical references about the discovery of scientific evidence related to them. The conclusions are presented in a direct and schematic style. You can read the full text article at the magazines website.

Universal neonatal screening is the only way to detect all the sickle cell disease cases, but it is only performed in the United States, England, the Netherlands, and several cities in Belgium, with selective screening targeted on "high-risk" population in France. According to the ENERCA article, newborns diagnosed with a major sickle cell syndrome should be referred to a designated pediatric sickle cell centre where the care of the baby will be organized. Parents should be informed by an expert physician or in the community by an experienced nurse counselor.

Two preventive tools are the prophylaxis with penicillin to prevent infections and transcranial Doppler scanning to identify children with an augmented risk of suffering a stroke and include them in a transfusion program. Education and psychological support, as well as a yearly checkup, will lead to a better management of the SCD.

Pain, acute chest syndrome, infections, acute anemia and stroke may complicate the course of the disease. These complications may occur together and be difficult to disentangle, a painful crisis frequently causing fever for instance. Guidance for a correct identification of the problem and a proper use of treatments is detailed in the article.

Finally, transplantation of hematopoietic stem cells from HLA-identical siblings is the only curative therapy for SCD. Ovarian tissue can be cryopreserved but it is still unclear how useful this can be in allowing future pregnancies. In conclusion, when transplantation is not an option Hydroxyurea and chronic transfusion are the main therapeutic lines. The ENERCA article discusses the correct application of treatments and some possible side effects to help professionals to define the better possible treatment for every patient.

This guideline is the first one of a series of ENERCA documents focussed on diagnosis and clinical management of sickle cell disease. The first author of the article is Dr. Mariane de Montalembert, from Hpital Necker-Enfants Malades and Universit Paris Descartes (France), who coordinated this publication. The work is part of the ENERCA Workpackage Public health issues and clinical management of patients with Sickle cell anaemia, leaded by Dr. Beatrice Gulbis, from Hpital Erasme (Brussels, Belgium).


Contact: lex Argem
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer

Related medicine news :

1. Stethoscope App gives iPhone New Clinical Skills
2. Sunquest Introduces Integrated Clinical Environment Physician Portal Solution in US
3. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
4. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
5. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
6. NOVAVAX Presents Positive Clinical Results at The World Health Organization Conference, Geneva, Switzerland
7. UCLA Health System Presents: How to Successfully Implement a Clinical Portal
8. TeraMedica Launches Evercore – Clinical Enterprise Suite 5.0 Now on Linux
9. Mesothelioma Clinical Trials List Offered by IQ Mesothelioma: Search Current Mesothelioma Treatment Options
10. MedQuist Launches EHR Integration for Dictations Associated with Template-based Clinical Documentation
11. Greenway Medical Technologies Donates Electronic Health Record, Clinical Research and Revenue Cycle Solutions to Northern Kentucky University
Post Your Comments:
(Date:11/30/2015)... DE (PRWEB) , ... November 30, 2015 , ... ... guest lecturer at a University of Delaware Accounting and Management of Information Systems ... software solutions for mid-market businesses. Sommer will speak at before student in the ...
(Date:11/30/2015)... ... November 30, 2015 , ... Cycling, running, and walking are regular Sunday activities ... morning of February 28, 2016. , That’s when the 7th annual ANF Group ... to help children and families at Joe DiMaggio Children’s Hospital. , The ...
(Date:11/30/2015)... ... November 30, 2015 , ... HemoTreat™ has announced that the ... ointment to its website. , “Our goal is simple:” says Michael Blasco, HemoTreat’s ... the comparison chart and ingredient list allows our customers to quickly see why, ...
(Date:11/30/2015)... ... , ... At Grand Dental PC, their priority is to deliver quality care ... problems, you need to turn to a dentist who listens and responds; an experienced ... friendly dentist who counsels you on the best ways to maintain and improve your ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... Dr. Seth ... three office locations, patients can visit Dr. Margulies to experience the best available orthodontic ... hold the title of "NJ Top Dentist"! , Orthodontics is the branch of dentistry ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , November 30, 2015 North America ... is expected to grow at a CAGR of 7.6% from 2015 ... valued at USD 135.6 million in 2014, and is expected to ... --> According to the new Market Research Report "North America ... By End User (Hospitals, ambulatory care, others) - Analysis And Forecast ...
(Date:11/30/2015)... , November 30, 2015 /PRNewswire/ ... --> adds a ... for 2010 - 2015 with comprehensive ... a range of deal types, such ... strategic alliances. ...
(Date:11/30/2015)... Nov. 30, 2015  Kevin Smith has been ... a global pioneer in wireless monitoring of vital ... MA , Mr. Smith will be responsible ... commercial strategy.  He will also directly oversee partnering ... clinical evidence for SensiumVitals, the first early warning ...
Breaking Medicine Technology: