Navigation Links
E. coli persists against antibiotics through HipA-induced dormancy
Date:1/15/2009

ll, for example," Brennan explains. To function, a protein must be able to close down on its target molecules - called substrates. The closed state is the active state.
  • HipB also might physically sequester HipA from EF-Tu because the HipA/HipB/DNA complex is located in E. coli's nucleoid, far from the bacteria's membrane where EF-Tu is mainly found.

    • HipA is free to cause trouble when its ties to HipB are broken; an infrequent occurrence which the authors note is likely caused by proteases tugging the smaller and structurally vulnerable HipB protein out of the complex.

    Protein kinases often bind to more than one protein, so there are likely multiple targets for the protein in E. coli and other gram-negative bacteria, Schumacher and Brennan said.

    Future research will focus on finding other HipA targets in E. coli, and kinase inhibitors will be examined for their ability to affect HipA function. If a promising inhibitor is found, its structure will be solved to clarify its binding mode and how it might be tweaked to bind HipA even better. "Structure-based drug design should provide the best chance at formulating highly specific and effective drugs against HipA," Schumacher said.


    '/>"/>

    Contact: Scott Merville
    smerville@mdanderson.org
    713-792-0661
    University of Texas M. D. Anderson Cancer Center
    Source:Eurekalert  

    1

    GOOD

    Page: 1 2 3

    Related medicine news :

    1. Direct recording shows brain signal persists even in dreamless sleep
    2. Raised Breast Cancer Risk Persists After Combo HRT Stopped
    3. Facial asymmetry persists despite surgery to correct congenital deformity
    4. HIV persists in the gut despite long-term HIV therapy
    5. Chronic infection persists by targeting stromal cell network in lymphoid organs
    6. AMA Claims Victory With Record Breaking Settlement in Case Against Insurer
    7. Report Finds That Raids Are Not an Effective Tool Against Human Trafficking
    8. Maslinic acid provides a natural defense against colon cancer
    9. Nose-spray vaccine against botulism effective in first tests
    10. New Drug May Work Better Against Chemo Side Effects
    11. Researchers Report Progress in Fight Against Fat
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    Related Image:
    E. coli persists against antibiotics through HipA-induced dormancy
    E. coli persists against antibiotics through HipA-induced dormancy
    (Date:12/4/2009)SCOTTSDALE, Ariz., Dec. 4 Healthcare Trust of America, Inc. ("HTA"), a self-managed, non-traded, real estate investment trust, announced the execution of a purchase and sale agreement to acquire a th
    (Date:12/4/2009)ANAHEIM, Calif., Dec. 4 Pamela Bowen, Chief Information Officer at Crescent Healthcare, was selected as a finalist for the "Chief Innovation Officer" Appy Award for transforming Crescent,s business w
    (Date:12/4/2009)Late recurrence is a risk for some pediatric cancers, particularly Ewing sarcomas and tumors of the central nervous system, according to a new study published online December 4 in the Journal of the
    (Date:12/4/2009)Case Western Reserve University researchers, from the School of Medicine,s Department of Nutrition, discovered two new metabolic pathways by which products of lipid peroxidation and some drugs of abus
    (Date:12/4/2009)Dental tourism is a phenomenon that was started by people that were looking for an alternative to the high price of dental work in the US, Canada, and other countries. In their search for lower priced
    Breaking Medicine News(10 mins):Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire a 92,500 Square Foot Medical Office Portfolio Located in Texas and Indiana 2Health News:Crescent CIO '09 Dreamforce Conference Speaker and Award Finalist 2Health News:Case Western Reserve researchers' new pathway discovery published as 'Paper of the Week' 2Health News:Mexican Dental Vacation Sees a Rush Of New Patients: Recession A Factor 2Health News:Mexican Dental Vacation Sees a Rush Of New Patients: Recession A Factor 3
    ...ight and friendly 7-year-old at Shaughnessy Elemen... fatal bacterial meningitis disease//. She had...l. But later when her parents tried to wake her up...o die of the disease in Massachusetts since 2003....
    ...drenaline rush at Disneyland Paris, though now, it...ird-flu storm//. Ruffled up, Disney land Paris is ...ad swan. This is especially unwelcome news, as pan...’ Force, spotted a dead swan in the adventure park...
    ...dermatologists have warned about increased exposur...been found that Vitamin D//, produced by the skin ...the risk of cancer. With increase in the number of... Vitamin D levels in the body can be increased by...
    ...ganization, Biomedical Tissue Services has been ac...uneral home in Brooklyn and distributing it to var... is said to have contracted HIV following transpla...cervical fusion surgery (bone graft implantation i...
    ...pill. But lately it is has been listed in the top ...sin officials identified Ambien in the bloodstream...here are signs that Ambien-related driving arrests...F.D.A) Susan Cruzan said the drug's current label ...
    ...als trust is going to cut off nearly 300 jobs afte...rmula that incurred huge losses. //Royal Cornwall ...hat is amounting to debts of ?8.1 million which m...cause it works on the logic that it costs much les...
    Other Medicine News:Health News:Sunlight Exposure Reduces Risk Of Breast, Prostate And Colon Cancer 2Health News:HIV Infected Body Parts Stolen: Biomedical Tissue Services To Face Legal Action 2Health News:Ambien Plus Alcohol Has A Bad Influence on the Drivers 2
    (Date:12/3/2009)NEW YORK, Dec. 3 Guidepoint Global, LLC , a leading primary research firm, today announced the launch of their Sleep Apnea Tracker, a monthly longitudinal data release that monitors and projects tre
    (Date:12/3/2009)SUNNYVALE, Calif., Dec. 3 Pharmacyclics, Inc. (Nasdaq: PCYC ), a biopharmaceutical company focused on developing and commercializing innovative small molecule drugs for the treatment of immune media
    (Date:12/3/2009)WILMINGTON, Del., Dec. 3 ParagonRx, a Delaware-based company specializing in pharmaceutical risk management and optimal medication use, will host a free webinar on Wednesday, Dec. 9, on the FDA,s dra
    Breaking Medicine Technology:Leading Primary Research Firm Guidepoint Global Announces Launch of Sleep Apnea Tracker 2Pharmacyclics to Host Webcast and Conference Call to Discuss Clinical Updates on Its HDAC and BTK Program as Presented at The American Society of Hematology Meeting Dec. 6 & 7 2Natural and Organic Consumers Focus on Health and Wellness Amidst Public Health Concerns 61152 1Natural and Organic Consumers Focus on Health and Wellness Amidst Public Health Concerns 61152 2K State program will give young professionals skills to protect water resources 10693 1High Altitude Mountaineer Will Cross Joins Tender 26apos 3Bs HealthiFeet Team to Raise Awareness On Foot Care for People Battling Diabetes 61149 1High Altitude Mountaineer Will Cross Joins Tender 26apos 3Bs HealthiFeet Team to Raise Awareness On Foot Care for People Battling Diabetes 61149 2High Altitude Mountaineer Will Cross Joins Tender 26apos 3Bs HealthiFeet Team to Raise Awareness On Foot Care for People Battling Diabetes 61149 3High Altitude Mountaineer Will Cross Joins Tender 26apos 3Bs HealthiFeet Team to Raise Awareness On Foot Care for People Battling Diabetes 61149 4
    ...Host Conference Call at 9:00 a.m. EDT-, MONTVALE,...aq: MEMY ) today announced top-line data from the...ontrolled Phase 2a study,of MEM 1003, a neuronal L...sease. The trial enrolled 183 subjects with mild t...in the United States and included monotherapy,subj...
    ...N.J. and NEW YORK, Oct. 12 Daiichi Sankyo,Inc. an...d today that they,have signed a contract for a co-...hi Sankyo,s AZOR(TM), a fixed combination of two,a...odipine and the,angiotensin receptor blocker, olme... letter of intent for the co-promotion agreement o...
    Other Medicine Technology:Memory Pharmaceuticals Announces Results for Phase 2a Trial of MEM 1003 in Alzheimer's Disease 2Memory Pharmaceuticals Announces Results for Phase 2a Trial of MEM 1003 in Alzheimer's Disease 3Memory Pharmaceuticals Announces Results for Phase 2a Trial of MEM 1003 in Alzheimer's Disease 4Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM) 2Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM) 3Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM) 4
    Microalbumin Linearity Control
    Total IgE Control
    Lyophilized Lipid Control
    High-sensitive CRP Control
    Medicine Products: