Navigation Links
Dynamin drug discovery team win prestigious international epilepsy grant
Date:6/18/2008

A drug discovery and development collaboration between leading Australian Institutions, the Children's Medical Research Institute (CMRI), University of Newcastle, University of Melbourne and Bio-Link Partners Ltd., has been announced as the Epilepsy Therapy Project, June 2008 New Therapy Grant winners. This prestigious research grant recognises their promising drug discovery program, which is focussed on development and commercialisation of small molecule inhibitors of the GTPase Dynamin, a key component of the synaptic vesicle cycle and a novel approach to treatment of epilepsy.

The two year US$278,800 grant to the Dynamin Drug Discovery Program will support the refinement of lead classes of inhibitors which have demonstrated efficacy in animal models towards clinical development and commercialisation. The Dynamin Drug Discovery Program consists of leading expertise in synaptic vesicle endocytosis and dynamin biology, medicinal chemistry and translational studies in acquired epilepsy models. Award of the New Therapy Grant recognises the potential of dynamin as a new molecular target for the design of a new class of therapeutics to treat epilepsy. In announcing the award, Joyce Cramer, President of the Epilepsy Therapy Project said " The Australian group exemplifies the ideal of collaboration among experts to work on a novel approach to limiting seizure propagation. We are eager to watch their progress toward human studies that will reveal the full potential of this effect on brain signaling".

The Epilepsy Therapy Project seeks to advance the development of new therapies for epilepsy, including new medicines and therapeutic devices. The grants committee consists of leading opinion leaders in the fields of epilepsy clinical practice and anti-epileptic drug (AED) research. The Program attracts applications from leading research groups and biotech companies worldwide. Consistent with the theme of translational research, all grant proposals must demonstrate a clear path from the lab to the patient.

A common feature of all AEDs is a reduction in synaptic transmission. The GTPase Dynamin represents a potentially highly efficacious target that indirectly modulates neurotransmitter loading, leading to reduced epileptic synaptic transmission, while limiting potential side effects. Dynamin mediates synaptic vesicle endocytosis (SVE), a process which replenishes synaptic vesicles prior to reloading and subsequent neurotransmitter release. Modulation of Dynamin limits the efficiency of SVE to retrieve vesicles, decreasing the rate at which neurons can recycle them to sustain synaptic transmission. Hence seizure activity is minimized through depleting the sustainability of neuronal burst firing, without directly influencing the synaptic transmission process. During regular physiological conditions synaptic transmission does not rely on such rapid vesicle replenishment limiting potential mechanistic side effects.

The Dynamin Drug Discovery Program represents an extensive collaboration between Professor Phil Robinson, CMRI (Dynamin Biology), Associate Professor Adam McCluskey, University of Newcastle (Medicinal Chemistry), Associate Professor Terence O'Brien, University of Melbourne, Department of Medicine, Royal Melbourne Hospital (Translational Models) and Bio-Link Partners Ltd. (Commercialization Strategy and Implementation). The program consists of an iterative drug discovery and development cycle for development of dynamin inhibitors as novel therapeutic candidates for epilepsy, other CNS disorders and cancer. The Robinson group originally cloned the human dynamin 1 isoform, and are leaders in the understanding of its biological functions and development of in vitro and cell function assays. In conjunction with the medicinal chemistry expertise of the McCluskey group, a large number of classes of small molecule and peptide inhibitors of dynamin have been developed. Ongoing collaborations with the Anticonvulsant Screening Program at the US National Institute of Neurological Disorders and Stroke and the O'Brien group have provided deep insights and capabilities in in vivo screening in a large range of different seizure models. Associate Professor O'Brien also provides clinical insights and expertise for lead selection and clinical testing. The Program technology is protected by an expanding patent estate covering broad composition of matter and method of use patents over compound and peptide classes and assay technologies. Overall, the Program represents a unique capability to exploit the potential of Dynamin as a novel therapeutic target for epilepsy.

Approximately one in 120 people have epilepsy, while up to 5% of the world's population may have a seizure at some time in their lives. Epilepsy is diagnosed when seizures are unprovoked and recurrent. Approximately only 70% of patients with epilepsy benefit from current treatments. There is a large unmet medical need for new therapeutic approaches to help those patients that do not receive benefit from current treatments, or suffer from undue side effects.


'/>"/>

Contact: Jens Tampe
j.tampe@bio-link.com
61-292-094-381
Research Australia
Source:Eurekalert

Related medicine news :

1. Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research
2. New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
3. Stem cell discovery sheds light on placenta development
4. Discovery of new signal pathway important to diabetes research
5. Immtech Announces Results From Hepatitis C Discovery Program
6. Discovery of new family of genetic mutations involved in inflammatory intestinal disease
7. Collaborative Drug Discovery and Myelin Repair Foundation Announce Partnership
8. Spirus Medical Announces 510(k) Clearance from FDA for Expanded Use of Endo-Ease(R) Discovery SB(TM)
9. Discovery of cell linked to learning and memory
10. Tianyin Pharmaceutical to Present at Roth Third Annual China Discovery Tour in Beijing on May 20, 2008 at 12:40 p.m. Beijing Time
11. Discovery of a novel mechanism for the development of colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... Calif. , June 23, 2016 ... CST on Thursday, July 7, 2016 , , , , ... ) , , , , EXPERT PANELISTS:  , , ... Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar ... The global pharmaceutical industry is witnessing an exceptional ...
Breaking Medicine Technology: