Navigation Links
Dynamic molecular mechanism to keep brain activity stable
Date:7/13/2009

In the brain, many types of synaptic proteins are spatio-temporally regulated to maintain synaptic activity at a constant level. Here, the Japanese research group led by Professor Masaki Fukata, Drs. Yuko Fukata and Jun Noritake in National Institute for Physiological Sciences, Japan, found that two types of palmitoylating enzymes finely-tune the location and function of a major synaptic protein, PSD-95, in different ways. They also found that this mechanism contributes to keeping synaptic activity stable when synaptic activity dynamically changes. The Japan Science and Technology Agency (JST) supported this study. They report the finding in Journal of Cell Biology published on July 13, 2009.

The research group focused on two types of palmitoylating enzymes, DHHC2 and DHHC3. Protein palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating synaptic proteins in neurons. Here, the research group found that DHHC3 is located in the cell body of neurons to palmitoylate newly synthesized synaptic proteins such as PSD-95, and move out them into dendrites of neurons. In contrast, DHHC2 are located mainly in dendrites of neurons. Dendritically localized DHHC2 mediates dynamic palmitoylation of PSD-95 at synapses upon extracellular signals. When synaptic activity decreases, DHHC2 translocates to the synaptic site to facilitate palmitoylation of synaptic proteins to keep synaptic activity at a constant level.

"We have already found 23 types of palmitoylating enzymes. Our finding suggests that individual palmitoylating enzymes have distinct functions in neurons. Some of palmitoylating enzymes are known to be differently related to neurological disorders such as mental retardation, schizophrenia and Huntington's disease. Therefore, this palmitoylating enzyme family may represent exciting therapeutic targets", said Professor Fukata.


'/>"/>

Contact: Masaki Fukata
mfukata@nips.ac.jp
81-564-595-873
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related medicine news :

1. Dominium Benefits Experiencing Dynamic Growth
2. CardioDynamics Announces Third Quarter 2007 Conference Call and Webcast
3. International Consulting Firm Health Fitness Dynamics Hired to Oversee Springbrook Inns Planned New Spa
4. Dynamic Energy Systems Goes Online and On-Demand
5. Dynamic Files Articles of Merger; Notifies Nasdaq of Merger with GeoPharma
6. Optimal systemic and splanchnic hemodynamic state after living-donor liver transplantation
7. Caught in the act: The dynamic dance of enzymes
8. Edge Dynamics New Dashboard Unlocks Value of Channel Data Enterprise-wide
9. Zimmer Spine Introduces New Rigid to Dynamic Stabilization Transition System
10. Danialle Karmanos Work It Out Launches Dynamic Blog
11. Engineers use bloods hydrodynamics to manipulate stem, cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... (PRWEB) December 26, 2014 It is said ... great dress. Today, UWDress.com, the famous wedding dress supplier, ... launches a site-wide cocktail gown promotion. , UWDress.com’s navy ... collection, and they come in high fashion styles. Simple dresses ... depending on the occasion; they are specially designed for those ...
(Date:12/26/2014)... December 26, 2014 “Many people become ... personal injury claim issues and phone calls with insurance ... an article featuring their free eBook on pedestrian ... eBook on pedestrian and bicycle auto accident claims assures ... fully capable of professionally handling their case while they ...
(Date:12/25/2014)... The microscopy market is estimated to grow ... million by 2019. Optical microscopy is the largest ... product segment is expected to show the fastest ... on nanotechnology, technological advancements, and increasing federal support ... Get Full Copy of Report @ http://www.marketsandmarkets.com/Market-Reports/world-microscopy-399.html ...
(Date:12/25/2014)... York, New York (PRWEB) December 25, 2014 ... the 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) ... LLP reports. According to an Order issued in the ... 20th, the Court will convene an open conference on ... Building and United States Courthouse in West Palm Beach, ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas ... BellasDress has chosen their best-selling lace wedding dresses, vintage ... holiday season. , Now, BellasDress.com features popular women’s ... at discount prices. The business hopes everyone can have ... , “All our elegant products are made with ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... million Americans, OptumHealth developed myOptumHealth.com to provide individuals seeking health ... easy-to-understand and actionable content, tools and resources. , ... ... -- OptumHealth Inc., the health and wellness business of UnitedHealth ...
... Medical Record and practice billing solutions for the healthcare industry, is ... Chief Commercial Officer. Flormann brings 25 years of experience in ... market development to Glenwood Systems. , ... Waterbury, CT ...
... University of Utah researchers have developed an automobile ignition ... sending text messages while driving. , The university has obtained ... a private company that hopes to see it on the ... $50 per key plus a yet-undetermined monthly service fee. ...
... Calif., Dec. 10 PADRES Contra El Cancer, an,organization ... children,with cancer and their families, will host its Annual ... 13, 2008. , ... afternoon playing,and sledding amongst 40 tons of snow while ...
... Walter Reed Soldiers Visit Atlantic City , , ... of a soldier who had been wounded in the Iraq conflict and ... the invitation for a visit to Harrah,s Resorts in Atlantic City. , ... young servicemen and women, recovering , from war injuries and ...
... (NYSE: VAR ) announced today that it will report ... of regular trading on Thursday, January 29, 2009. The news ... parties at 2:00 p.m. PT. , , ... January 29, 2009. The news release and information on the conference ...
Cached Medicine News:Health News:OptumHealth Launched myOptumHealth.com, Health and Wellness Information Destination with Clinically Reviewed Content, Tools and Resources 2Health News:OptumHealth Launched myOptumHealth.com, Health and Wellness Information Destination with Clinically Reviewed Content, Tools and Resources 3Health News:OptumHealth Launched myOptumHealth.com, Health and Wellness Information Destination with Clinically Reviewed Content, Tools and Resources 4Health News:OptumHealth Launched myOptumHealth.com, Health and Wellness Information Destination with Clinically Reviewed Content, Tools and Resources 5Health News:Glenwood Systems, LLC Appoints Ron Flormann Chief Commercial Officer 2Health News:Car key jams teen drivers' cell phones 2Health News:Car key jams teen drivers' cell phones 3Health News:Car key jams teen drivers' cell phones 4Health News:PADRES Contra El Cancer to Host its 10th Annual Posada Holiday Celebration for Children with Cancer 2Health News:Wounded Warriors to be Holiday Guests of Harrah's Entertainment 2Health News:Varian Medical Systems Schedules First Quarter FY2009 News Release and Conference Call 2Health News:Varian Medical Systems Schedules First Quarter FY2009 News Release and Conference Call 3
(Date:12/24/2014)... , Dec. 24, 2014  Actavis plc (NYSE: ... Company has received a complete response letter from ... its New Drug Application (NDA) for the fixed-dose ... treatment of hypertension.   Photo - ... disappointed in the receipt of a complete response ...
(Date:12/24/2014)... , Dec. 24, 2014 Kinex Pharmaceuticals announced ... KX2-361 at Roswell Park Cancer Institute. KX2-361 ... drug that has shown potent inhibitory activity against a ... that are resistant to Temozolomide (T98G), the most widely ... a well-established brain tumor mouse model, KX2-361 consistently clears ...
(Date:12/24/2014)... 2014  Conkwest, Inc., the Natural Killer Cell ... Killer (NK) cell-line platform, Neukoplast® (NK-92™) as an ... , NantWorks founder, physician scientist and biotechnology entrepreneur, ... approximately $48 million of the Company,s Class A ... will be named Co-Chairman of the Conkwest Board ...
Breaking Medicine Technology:Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: