Navigation Links
Dutasteride not a cost-effective way to prevent prostate cancer in some men
Date:2/8/2011

DALLAS Feb. 8, 2011 The popular drug dutasteride may not be a cost-effective way to prevent prostate cancer in men who are at elevated risk of developing the disease, according to findings by a UT Southwestern Medical Center researcher.

In a study available in the January issue of Cancer Prevention Research, investigators found that the medication, at an annual cost of $1,400, is impractical when compared to the marginal impact on survival and quality of life in at-risk groups. The drug is indicated for the treatment of enlarged prostates but also is widely prescribed for chemoprevention.

"Because prostate cancer is the most common cancer in men, the implications of this data are significant since there could be millions of men who would be eligible for anti-cancer drugs," said Dr. Yair Lotan, associate professor of urology at UT Southwestern. "Prior to instituting a chemoprevention strategy to a large population, the utility and cost need to be well understood. Whether a medication improves survival, how it affects quality of life, and what its financial implications will be are all critical issues. Because dutasteride typically is prescribed for the lifetime of the patient, and therefore taken daily for decades, the cost issue is particularly relevant."

Prior research has shown that dutasteride reduced the relative risk of prostate cancer over a four-year period by 22.8 percent, but questions have remained about its cost-effectiveness. The current study analyzed the lifetime health-related costs of the drug in patients at greater risk of developing prostate cancer and compared them to other factors, such as quality and length of life.

Dr. Lotan and his colleague, Dr. Robert Svatek of UT Health Science Center at San Antonio, used a Markov probability model to compare the lifetime cost of taking dutasteride with no therapy. They used data from a previous trial and studies that evaluated outcomes of patients with prostate cancer, including treatment-related complications to create the model. The primary outcome was measured in quality-adjusted life years (QALY), which takes into account both quality and quantity of life.

"The study found that dutasteride was not cost-effective for chemoprevention unless and until a strategy is developed for targeting very high-risk patients and the cost of the drug decreases," said Dr. Lotan. "For the average man, the drug provides minimal survival benefits, and the reduction on treatment-related complications does not compensate for the high costs of every man taking the drug for many years."


'/>"/>

Contact: Rachel Skei Donihoo
rachel.donihoo@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. European Urology: Editorial about REDUCE trial underlines value of dutasteride
2. Conventional, annual Pap smear cost-effective follow-up after cervical lesion treatment
3. Web-based questionnaire can be cost-effective tool for survey responses
4. Testing African couples for HIV is cost-effective prevention strategy
5. Wider statin use could be cost-effective preventive measure, Stanford study finds
6. Centralized health care more cost-effective, offers better access to preventive services
7. Trauma center care cost-effective
8. UNC physician authors editorial on cost-effectiveness study for colon cancer screening
9. Colorectal cancer screening in Canada is cost-effective
10. Antiviral therapy during compensated cirrhosis most cost-effective approach
11. Hospital Focus 5 Announces Contract with Connecticut Hospital to Improve Quality, Productivity and Cost-Effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... , ... Sandbox, one of the nation’s leading independent full-service ... created position of executive vice president, chief creative officer.     , In his new ... LA offices. He reports to Nancy Finigan, president of those offices. , “As ...
(Date:5/3/2016)... ... May 03, 2016 , ... University of the ... the launch of its Associates and Bachelor's degrees in Health Studies. Leading figures ... University, Dr. Torsten N. Wiesel; Chairman and CEO of Fortune 500® company Henry ...
(Date:5/3/2016)... ... , ... Each year, about 800,000 people suffer from cerebral vascular accidents, or ... account for one death every four minutes. Many people who survive a stroke ... launching a video series called “Your Brain,” in conjunction with its medical journal “Balance,” ...
(Date:5/3/2016)... ... May 03, 2016 , ... For the sixth consecutive ... Communication Technology (ICT) companies in the annual Branham300 listing. For 23 years, the ... as ranked by revenue. , “We are honored to be on the ...
(Date:5/3/2016)... ... ... Branches, Inc. is proud to have been selected as a Macy’s grant ... Miami. Macy’s is a wonderful community partner and has helped to support Branches’ student ... and academic support to elementary students 5 days a week. Summer Shade, a 7 ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... May 2, 2016 Leading Economies with Fastest Real GDP ... d,Ivoire 8.6 Uzbekistan 8 Ireland 7.8 India 7.3, , Source: ... nations , which comprises of Brazil , Russia ... South Africa , registered the fastest GDP growth during the ... China , recession in Brazil and ...
(Date:4/29/2016)... 29, 2016  In the next ten years, ... from systems dependent on CRTs monitors to those reliant ... CRT Medical monitors and will automatically sync to ... of foreseeable benefits to this technological advancement, it ... have to be replaced in order to be ...
(Date:4/29/2016)... Automation is one of the ... the growing demands for productivity in speed, accuracy, throughput ... are already adept of a wide range of functions ... labor. Instrumentation continues to evolve, and is poised to ... few years ago. Originally used mostly by the big ...
Breaking Medicine Technology: