Navigation Links
Duska Therapeutics and DSM Pharmaceuticals in Manufacturing Collaboration for PSVT Drug Product
Date:11/10/2008

Pivotal Phase 3 Clinical Trial For Duska's ATPace In Planning Stage

LA JOLLA, Calif. and PARSIPPANY, N.J., Nov. 10 /PRNewswire-FirstCall/ -- Duska Therapeutics, Inc., (OTC Bulletin Board: DSKA) and DSM Pharmaceuticals, Inc., announced today that they have entered into a preliminary agreement to collaborate on the manufacture of commercial batches of ATPace for Duska's planned pivotal Phase 3 clinical trial in paroxysmal supraventricular tachycardia (PSVT). ATPace will be produced at DSM's commercial facilities in Greenville, North Carolina.

ATPace, a stable liquid formulation of adenosine 5'-triphosphate (ATP) for intravenous injection, is an investigational drug for the acute termination of PSVT. The bradycardic effect of ATP, in particular its blockade of atrio- ventricular nodal conduction, has been shown in numerous published clinical studies to safely and effectively terminate re-entrant PSVT involving the atrio-ventricular node. Design of a pivotal Phase 3 clinical trial for ATPace in PSVT is in the planning stage.

PSVT, one of the most common cardiac arrhythmias, is a rapid, regular heart rate originating in the atria. It has been estimated that there are 89,000 new cases of PSVT per year and approximately 570,000 persons with PSVT in the United States alone.

Currently, adenosine is the only approved treatment for PSVT in the United States. Duska believes that the initial dose of ATPace will be significantly more efficacious than the initial labeled dose of adenosine in terminating PSVT. While both ATP and adenosine inhibit atrio-ventricular nodal conduction, ATP is believed to have dual inhibitory action; one mediated by adenosine, the product of its rapid enzymatic degradation, and the other a triggered vagal reflex. Vagal maneuvers aimed at enhancing vagal tone to the heart, and thereby suppressing atrio-ventricular nodal conduction, have been clinically used to terminate tachycardia. Injectable formulations of ATP have b
'/>"/>

SOURCE Duska Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Duska Therapeutics Acquires Technology for ATPotent Sperm Motility Program
2. Duska Therapeutics Receives Comments From FDA on Phase 3 ATPace(TM) Protocol Synopsis
3. Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals
4. Duska Therapeutics Plans 505(b)(2) NDA Filing Route for ATPace(TM)
5. Transition Therapeutics to Hold Conference Call on First Quarter Fiscal 2009 Financial Results on Monday, November 10th, at 4:30 P.M. EST
6. Nektar Therapeutics Repurchases $100 Million of Convertible Debt and Reports Third Quarter 2008 Financial Results
7. Cell Therapeutics, Inc. (CTI) Rodman & Renshaw Healthcare Conference Presentation to be Webcast
8. Cornerstone Therapeutics Announces New Board of Directors
9. Orexigen(R) Therapeutics Announces Webcast of Third Quarter Financial Results on November 6, 2008
10. Cornerstone BioPharma Announces Completion of Merger with Critical Therapeutics
11. Cell Therapeutics, Inc. (CTI) Oppenheimer & Co. Healthcare Conference Presentation to be Webcast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... , ... Cosmetic Town has proven itself as the leader ... procedures including, but not limited to, abdominoplasty, blepharoplasty, rhinoplasty and septoplasty. The ... , Staying up to date with the latest cosmetic trends has never ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Creating one ... , is in pursuit of a visionary image that goes beyond the boundaries of ... New Hope IVF has reached extraordinary heights with dependable patient support, affordable treatments, unending ...
(Date:7/31/2015)... ... 31, 2015 , ... The Mount Sinai Health System will work with Columbia ... of related, experimental treatments. The collaboration moves into the next phase with the recent ... of five state licenses to produce and dispense medical marijuana. , Mount Sinai ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently, ZKB filed another ... Western Division (Case No. 3:15-cv-00397) involving the Implanon® contraceptive implant . , ... of their Implanon® implants, inability to locate the implants, unsuccessful and invasive attempts ...
(Date:7/31/2015)... ... 2015 , ... Florida Hospital Tampa has started treating select ... targeted delivery of fluids to selected sites in the peripheral vascular system. Patients ... the device that provides direct, local delivery of chemotherapy to the pancreas. This ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town: Now Providing Interactive And Vital Medical Knowledge 2Health News:New Hope IVF Now Offers Most Affordable Assisted Reproductive Treatment in the UAE 2Health News:New Hope IVF Now Offers Most Affordable Assisted Reproductive Treatment in the UAE 3Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 2Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 3Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 3Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 3Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 4
... agents could make it possible to "see" tumors in ... compounds, derived from inhibitors of the enzyme cyclooxygenase-2 (COX-2) ... have broad applications for cancer detection, diagnosis and treatment. ... in a paper featured on the cover of the ...
... Dennis Thompson HealthDay Reporter , FRIDAY, Oct. 7 ... not know it, but the process that created a new ... Blood contained in the umbilical cord and placenta is ... to treat leukemia, lymphoma and many other life-threatening diseases, according ...
... Parents of young caffeine consumers take heed: that high-calorie ... obesity risk. In fact, according to a double-blind, placebo-controlled ... response to caffeine may predict how he or she ... in risk for abuse of other more serious drugs ...
... "stop and smell the roses," it,s likely your brain is ... New research from Northwestern Medicine offers strong evidence that the ... smells -- setting up a mental expectation of a scent ... important because it provides animals -- in this case, humans ...
... HealthDay Reporter , WEDNESDAY, Oct. 5 (HealthDay News) -- Steve ... to personal computers, then the iPod, the iPhone and the iPad, ... was 56. "Apple has lost a visionary and ... the company said in a statement it posted on its website ...
... Gardner HealthDay Reporter , THURSDAY, Oct. 6 (HealthDay ... has once again focused attention on cancers of the pancreas, ... Jobs, tumor was actually one with a better prognosis than ... Patrick Swayze. In fact, the type of cancer that ...
Cached Medicine News:Health News:Imaging agents offer new view of inflammation, cancer 2Health News:As One Life Starts, Another May Be Saved 2Health News:As One Life Starts, Another May Be Saved 3Health News:As One Life Starts, Another May Be Saved 4Health News:Jonesing for java: Could caffeine use predict risk for cocaine abuse? 2Health News:Sniffing out the brain's predictive power 2Health News:Steve Jobs, Visionary Leader of Apple Inc., Dies at 56 2Health News:Steve Jobs, Visionary Leader of Apple Inc., Dies at 56 3Health News:Pancreatic Cancer: A Stubborn Foe 2
(Date:7/31/2015)... More than 1,500 substance abuse prevention and ... Indianapolis Aug. 2-6 for Community ... Institute . The week-long training, held at the JW ... our nation,s biggest public health challenges – youth drug ... a one-of-a-kind intensive training opportunity, offering more than 70 ...
(Date:7/31/2015)... , July 31, 2015 The Physician-Patient ... release on July 28, 2015, "Surviving Your Hospital ... Fundraising for Patient Safety." A sentence ... should read: "PPAHS is a member ... on Opioids. For more information on the National Coalition ...
(Date:7/31/2015)... July 31, 2015  Xcelience, a contract development ... has made a structured cash investment in Powdersize, ... in milling, micronization and powder size classification within ... Powdersize,s business while simultaneously adding a complete set ... of capabilities. "As we continue ...
Breaking Medicine Technology:Community Leaders From Across The Country Head To Indianapolis For CADCA 2015 Mid-Year Training Institute Aug. 2-6 2Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3
... May 29, 2012  DebMed®, creator of the world,s ... on the World Health Organization,s (WHO,s) Five Moments, ... has increased hand hygiene compliance by five to ... using the DebMed GMS™ electronic monitoring system and supporting ...
... Inc. (Nasdaq: NBIX ) announced today that Kevin ... be presenting at the Jefferies 2012 Global Healthcare Conference in ... on Tuesday, June 5 at 2:00 p.m. Eastern Time / ... may be accessed on the Company,s website at http://www.neurocrine.com ...
Cached Medicine Technology:Greenville Hospital System Achieves Dramatic Improvement in Hand Hygiene Compliance Rates Using New Technology from DebMed® 2Greenville Hospital System Achieves Dramatic Improvement in Hand Hygiene Compliance Rates Using New Technology from DebMed® 3
... Craftsmanship have produced the finest ... Ocutek® now makes them available ... the coveted Meisterbrief certificate, which ... qualified to become Ocutek instrument ...
... Centuries of German Craftsmanship have ... in the world. Ocutek now ... Only holders of the coveted ... eight-year apprenticeship, are qualified to ...
... Centuries of German Craftsmanship have ... in the world. Ocutek now ... Only holders of the coveted ... eight-year apprenticeship, are qualified to ...
1mm by 7mm horizontal punch. Flat serrated handle. Overall length 87mm....
Medicine Products: