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Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals
Date:5/14/2008

LA JOLLA, Calif., May 14 /PRNewswire-FirstCall/ -- Duska Therapeutics, Inc. (OTC Bulletin Board: DSKA.OB) ("Duska" or the "Company") announced today that scientists from the University of Pennsylvania's Center for Research on Reproduction and Women's Health have published the results of the Company's sponsored study showing that extracellular ATP (adenosine 5'-triphosphate) improves sperm motility and increases fertilizing capability in mice.

The data was published online in the journal Biology of Reproduction (http://www.biolreprod.org/cgi/content/abstract/biolreprod.107.065565).

The University of Pennsylvania scientists studied sperm obtained from two mouse strains: one with normal and the other one with low fertilization capacity. Extracellular ATP treatment of these sperm in vitro (outside of the body) resulted in improved sperm motility parameters and was associated with a rapid increase in the level of intracellular calcium. The effect was inhibited by two P2 receptor antagonists. Furthermore, extracellular ATP treatment of mouse sperm resulted in increased success rates of in vitro fertilization (IVF) procedures. The improved fertilization rate was much more pronounced when sperm from the mouse strain with low fertility were used.

The authors suggest that ATP's activation of P2 receptors to modulate sperm function may be beneficial for artificial reproductive techniques.

"We are extremely pleased with the positive results of sperm treatment with ATP, which were obtained in this second Duska-sponsored study," said Dr. Amir Pelleg, Duska's President and Chief Scientific Officer. "These results indicate that the mechanism of action of extracellular ATP on improving sperm motility and fertilization potency is mediated by P2 receptors and increased level of intracellular calcium. The data further support the development of ATPotent(TM
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