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Duska Therapeutics Receives Comments From FDA on Phase 3 ATPace(TM) Protocol Synopsis
Date:8/12/2008

iginating in the atria. It has been estimated that there are 89,000 new cases of PSVT per year and approximately 570,000 persons overall with PSVT in the United States alone.

Currently, adenosine is the only approved treatment for PSVT in the U.S. Duska believes that the initial dose of ATPace will be significantly more efficacious than the initial labeled dose of adenosine in terminating PSVT. While both adenosine triphosphate and adenosine inhibit atrio-ventricular nodal conduction, adenosine triphosphate is believed to have dual inhibitory action; one mediated by adenosine, the product of its rapid enzymatic degradation, and the other, a triggered vagal reflex. Vagal maneuvers aimed at enhancing vagal tone to the heart, and thereby suppressing atrio-ventricular nodal conduction, have been clinically used to terminate tachycardia. Injectable formulations of adenosine triphosphate have been approved in Europe for over 50 years as safe and efficacious treatments for PSVT. Duska has established its own safety database for ATPace, which was obtained in its Phase 1 and 2 clinical trials, and has obtained more than 1,000 patients records from other clinical trials.

About Duska Therapeutics, Inc.

Duska Therapeutics, Inc. (Duska) is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging new pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which by several pharmaceuticals constitute novel therapeutic modalities for the treatment of major cardiovascular disorders. Duska is developing a portfolio of investigational medicines, two of which are in late stages of clinical testing. Duska's ATPace(TM) is expected to enter a pivotal Phase 3 clinical trial for the treatment of paroxysmal supraventricular tachycardia. Duska's CDP-1050 is expected to commence a Phase 2 clinical trial for the
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SOURCE Duska Therapeutics, Inc.
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