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Duska Therapeutics Acquires Technology for ATPotent Sperm Motility Program
Date:10/29/2008

Technology Intended To Reduce Failure Rates Of In Vitro Fertilization and

Intrauterine Insemination Procedures

LA JOLLA, Calif., Oct. 29 /PRNewswire-FirstCall/ -- Duska Therapeutics, Inc. (OTC Bulletin Board: DSKA) announced today that it has entered into a series of agreements to acquire exclusive worldwide rights from several inventors to develop and commercialize technologies relating to the use of adenosine 5'-triphosphate (ATP) to improve motility of human and animal sperm. ATPotent is a novel ATP-based sperm processing medium designed to reduce failure rates of in vitro fertilization (IVF) and intrauterine insemination (IUI) procedures.

Male factor infertility is implicated in about half of the six million infertile couples in the US. Lack of, or low sperm motility or movement, also known as asthenozoospermia, is a common cause of human male infertility. It has been reported in the medical literature that the prevalence of asthenozoospermia in infertile men is approximately 82 percent. Currently, there is no FDA-approved product that enhances sperm motility.

Duska's sponsored studies at the University of Pennsylvania and the University of Padua (Italy) have shown that ATP treatment of poorly motile human sperm in vitro (outside of the human body) resulted in improved motility parameters and increased frequency of hyperactivated sperm. The improved motility parameters were also observed in human sperm derived from males with asthenozoospermia and in thawed cryopreserved human sperm.

Results from these recent studies support earlier observations from a non-Duska sponsored European study in which increased success rate of IVF procedures were observed when ATP-treated sperm derived from infertile males with asthenozoospermia were used.

"Today's announcement underscores Duska's commitment to develop novel targeted therapies utilizing ATP," said Amir Pelleg, PhD, Duska's President and Chief Scientific Offi
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SOURCE Duska Therapeutics, Inc.
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