Navigation Links
Duke team finds new clues to how cancer spreads
Date:6/27/2011

enchymal or connective tissue-like cell. This EMT may underlie much of the treatment resistance and ability of cancer cells to spread.

Current FDA-approved blood tests that detect circulating tumor cells flag molecules associated with epithelial transitions; however, the Duke team found additional markers associated with mesenchymal origins, adding new targets that could be used to enhance the usefulness and sensitivity of the tests.

"Cancer is a hijacking of that normal embryonic stem cell process," Armstrong said. "It reactivates this silent program that is turned off in adult cells, allowing tumor cells to move throughout the body and become resistant to therapy."

Armstrong said the involvement of EMT/MET processes in tumor growth is a relatively new finding that is gaining acceptance among cancer scientists. The discovery by the Duke team adds strong evidence that the EMT/MET processes are underway when a patient's cancer is spreading.

"In my opinion this work presents some of the most compelling data for the existence of epithelial-mesenchymal transitions in human cancer," said Mariano A. Garcia-Blanco, professor of medicine, molecular genetics and microbiology, and senior author in the work.

"This work should pave the way for studies to understand the mechanisms underlying these transitions in humans and their importance in disease progression and therapy," said Garcia-Blanco, who is also director of the Duke Center for RNA Biology.

The Duke team additionally noted that tumor cells appear to be most dangerous when they can easily transition between EMT and MET in a stem cell-like phase of changability that enables them to grow, spread and resist treatment.

That finding could provide new opportunities for novel therapies that target these morphing mechanisms.

"This is not just for a biomarker, it's a direction to take therapies as well," Armstrong said. "It's a new horizon."


'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TV drama can be more persuasive than news program, study finds
2. Study finds racial gaps continue in heart disease awareness
3. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
4. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
5. New American Heart Association Survey Finds Heart Disease and Stroke Patients Face Significant Barriers in Obtaining Quality, Affordable Care
6. Survey Finds Many Men Complaining of Ill-Fitting Condoms
7. Research finds hazards from secondhand smoke in bars and restaurants
8. Kaiser Analysis Finds Record Medicaid Enrollment Growth in 2009
9. Battlefield camaraderie yields long-term dividends for veterans, study finds
10. More Bars Equals More Assaults, Study Finds
11. Survey finds significant racial differences in lung cancer beliefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... A recent survey found that the most ... skin health and beauty were: “Connections,” “climate,” “career” and ... and health advocate and radio host Sharon Kleyne agrees ... survey and the Four C’s.* Kleyne notes, however, that ... would benefit from paying attention to one’s daily fresh ...
(Date:12/15/2014)... Veretekk.com, Inc. announced today a strategic alliance ... Ocean Avenue has secured exclusive benefit to the strategic ... JM Ocean Avenue is a direct sales company ... and JM International, with partial ownership coming from JM ... , “After nearly 2 decades of servicing the industry ...
(Date:12/15/2014)... West Palm Beach, FL (PRWEB) December 15, 2014 ... Urgent Care , knows that holidays can be a daze ... accidents. From slips and falls while decking halls, to burns ... are plenty of holiday hazards that can happen at any ... reason for pain, MD Now has made a list of ...
(Date:12/15/2014)... Beltsville, MD (PRWEB) December 15, 2014 ... and services today released “ Social Media Cheat Sheets ... cultivating a community that drives results on the top ... a marketing program. It helps drive awareness, engagement, and ... conversions. For marketers to make an impact on new ...
(Date:12/15/2014)... HealthDay Reporter FRIDAY, Dec. ... reassure the millions of American women who have migraine: The ... "There is no association between migraine and breast cancer risk," ... at Harvard Medical School. "There is no positive association, so ... protective effect either." About 18 percent of American women ...
Breaking Medicine News(10 mins):Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 2Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 4Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 2Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 3Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2
... Cancer progression is commonly thought of as a process involving ... which cancer cells leave the primary tumor and spread to ... Cancer Center shows that circulating tumor cells cancer cells ... other areas of the body can also return to ...
... , NEW YORK, Dec. 24 ... the Children,s Health Fund , a ... disadvantaged and medically underserved children, today released the following statement on ... Harry Reid: , "First and foremost, we applaud the Senate ...
... , WASHINGTON, Dec. 24 DNC Chairman Tim Kaine ... the Patient Protection and Affordable Care Act, landmark health care ... after overcoming a series of procedural hurdles and delay tactics ... ever reaching the Senate floor for a vote on final ...
... , WASHINGTON, Dec. 24 The following ... Medical Association: , "Today, the Senate took an historic ... coverage to millions of Americans and strengthening the private insurance ... The AMA supported passage of the bill because it ...
... House plan, before proposal can become law , THURSDAY, Dec. ... a Christmas Eve gift on Thursday with passage of a ... million uninsured Americans. , Obama said the Senate bill contains ... since his inauguration on Jan. 20. "Every single criteria for ...
... ... firms to have attained this highest level , ... (PRWEB) December 24, 2009 -- Partners Consulting’s Managed Services ... CMMI Level 5 Certification, the highest certification level of the Software Engineering Institute (SEI) ...
Cached Medicine News:Health News:'Self-seeding' of cancer cells may play a critical role in tumor progression 2Health News:Children & Health Reform: Where We Stand 2Health News:Children & Health Reform: Where We Stand 3Health News:DNC Chairman Tim Kaine Calls Senate Vote Historic, Says Landmark Health Reform Bill Is a Victory for the American People 2Health News:AMA: Senate Bill Passage Historic, More Work to Do in Conference 2Health News:Senate Passes Health Reform Package 2Health News:Senate Passes Health Reform Package 3Health News:Senate Passes Health Reform Package 4Health News:Partners Consulting's Managed Services Division Achieves CMMI Level 5 Certification 2
(Date:12/17/2014)... Ariz. , Dec. 17, 2014  Beamz ... state-of-the-art interactive music products, today announced that it ... a leading manufacturer and supplier of innovative prosthetic, ... As part of the agreement, RSL Steeper ... bundled solution specifically configured for use within UK ...
(Date:12/17/2014)...  RXi Pharmaceuticals Corporation (NASDAQ: RXII ... and commercializing innovative therapies addressing major unmet medical ... in its first Phase 2a study, RXI-109-1301.  The ... 1-month findings that were reported in September of ... http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , , , ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and ... the addition of the "MEMS Gyroscopes Analog ... Analysis" report to their offering. ... gyroscopes for tactical grade applications made a lot ... term of reliability. They are now accepted in ...
Breaking Medicine Technology:Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate Sensor Reverse Costing Analysis 2
... DES MOINES, Iowa, Oct. 16 Protocol ... and announced a partnership,with Hallmark Insights to ... to users of the ConXus health improvement ... and fulfillment services,for reward points earned by ...
... K. Khouri, M.D. a noted Plastic,and Reconstructive Surgeon, ... a,clinical trial performing a minimally invasive breast reconstruction,technique ... grafts primarily on women who have had a ... Typically, breast reconstruction procedures involve major, "open",surgery that ...
Cached Medicine Technology:PDHI Launches ConXus Rewards, Announces Partnership With Hallmark Insights to Support Incentive-Driven Wellness Programs 2New Minimally Invasive Breast Reconstructive Procedure for Breast Cancer Patients - Actively Recruiting Participants for Clinical Study 2
... Design for Unparalleled Comfort Pick one of ... balance. Notice the trigger and ejector positionsright where ... our pipettors are ergonomically designed to help avoid ... pipetting. Productivity In The Palm Of Your ...
... best value in high performance electronic pipetting!, ... lightweight design reduce hand fatigue and strain ... tip ejector , Color coding for easy ... for greater performance use Hamilton AdvanTip Low ...
... The Finnpipette BioControl ... innovative features as the ... universal handle fits all ... single channel tip cone ...
... Entire Column of a 384 Well Plate at ... 384 well plates, you need a pipettor that ... exactly what you get with our 16-channel Impact ... Impact/Impact2), this innovation was specifically designed to allow ...
Medicine Products: