Navigation Links
Duke researchers describe how breast cancer cells acquire drug resistance
Date:5/7/2013

DURHAM, N.C. -- A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death. The discovery provides new avenues to overcome drug resistance, according to researchers at Duke Cancer Institute.

"We've revealed multiple new signaling pathways that regulate cell death," said Sally Kornbluth, PhD, vice dean of Basic Science and professor of Pharmacology and Cancer Biology at Duke University School of Medicine. "And we've shown, at least in one disease, these signaling pathways can go awry in drug resistance. It also suggests you could manipulate these other pathways to overcome drug resistance."

The researchers -- co-directed by Kornbluth and Neil Spector, M.D., associate professor of medicine at Duke -- identified a protein that effectively shuts down the signals that tell a cell to die, enabling cancer cells to keep growing. That protein, MDM2, is already generating intense interest in the cancer research community because it is a master regulator of the tumor suppressor protein called p53.

Findings are published in the May 7, 2013, issue of the journal Science Signaling.

The Duke research team, with assistance from collaborators at the University of Michigan, identified a new role for MDM2 in activating cell death pathways independent of its role in regulating p53, a known initiator of cell death. More than half of all human tumors contain a mutation or deletion of the gene that controls p53.

The researchers began by studying four different types of breast cancer cells that were able to keep growing despite treatment with lapatinib, a powerful drug that targets two growth pathways commonly disrupted in breast cancer, HER2 and epidermal growth factor receptor. They found that in each case, the drug resistance could be traced to the presence of high levels of MDM2, which was found to be
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. CWRU School of Medicine researchers discover new target for personalized cancer therapy
2. U of M researchers discover link between heart, blood, and skeletal muscle
3. Researchers determine where best to place defibrillators
4. Researchers plot locations where AEDs could save more lives
5. Gene Mutation Linked to Migraines, Researchers Say
6. Discovery of New Cause of Congenital Hydrocephalus Opens the Door to Collaborative Research Study, Hydrocephalus Association Commends Researchers
7. Northwestern Medicine researchers work to improve heart attack response time
8. NYU and NYU Langone researchers devise method for enhancing CEST MRI
9. Medicaid-insured children have limited access to dermatologists, SLU researchers find
10. Federally funded research & development centers employed more than 3,000 postdoctoral researchers
11. 5 honored with AcademyHealth Presidential Scholarship for New Health Services Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... 6 Minutes to Skinny , a fat loss ... is showing men and women of all ages how they ... using simple 6-minute exercises and easy-to-follow lifestyle tips daily, has ... , “When it comes to losing body fat, unfortunately ... all people,” reports Michaels. “Metabolism plays a big role in ...
(Date:9/20/2014)... 2014 Increases in household, construction ... waste treatment volumes. However, government regulations and higher ... landfill. According to IBISWorld industry analyst Alen Allday, ... aimed at reducing the volume of waste generated, ... recovered.” Still, a large proportion of waste generated ...
(Date:9/20/2014)... September 20, 2014 As testosterone ... in federal court, Bernstein Liebhard LLP notes that ... (FDA) have voted overwhelmingly to recommend that prescription ... be subjected to further study in order to ... published on September 18th by Bloomberg.com, the panel ...
(Date:9/20/2014)... 2014 (HealthDay News) -- As flu season approaches, the ... to get a flu shot and a checkup, according ... care doctor can vaccinate people against the flu, and ... have. Retail stores may provide flu shots for their ... Dr. Jorge Parada, medical director of infection prevention and ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 As ... http://www.injurybeacon.com/power-morcellator/ ) in gynecological surgeries continue to ... insurer has announced plans to end coverage for ... its website last month, Harrisburg, Pennsylvania-based Capital BlueCross ... 1, 2014. The insurer said its decision was ...
Breaking Medicine News(10 mins):Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3Health News:Get a Flu Shot During Checkup, Doctor Says 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3
... -- Revenue of $99.7 million, up 23.6% year-over-year or up 30.9% ... of $11.3 million or $0.32 per diluted share, compared to a ... Highlights: -- Revenue of $423.4 million, up 45.5% ... -- Net income of $24.0 million or $0.68 per diluted ...
... Johnson & Johnson/Basilea,s or Forest/Novexel,s Drug Could Be ... Report from AMR and Decision ResourcesMALVERN, Pa. and ... (AMR) and Decision Resources find that activity against ... attributes influencing surveyed physicians, antibiotic selection for the ...
... students react better to stress, are less fatigued, have more ,integrated, brains , , , , , ... , , , ... , , , ... VIDEO: , Fred Travis, lead author and director of MUM,s Center for Brain, ,Consciousness and ...
... The Board of the Walter and Eliza Hall Institute ... the Institute,s next Director.Announcing Professor Hilton,s appointment as Director-Designate, ... that the directorship of WEHI is among the most ... world. This fact had demanded the most rigorous global ...
... ON, Feb. 24 /PRNewswire-FirstCall/ - Nuvo Research Inc. (TSX: ... research and development of drug products delivered to and ... delivery technologies, today announced that Nuvo,s INSIGHT(TM) platform, developed ... fqubed, Inc., has been selected as one of four ...
... Hard-Pressed Business SectorKIRKLAND, Wash., Feb. 24 For people ... healthcare front. They can often insure themselves for less, ... can use company dollars for a tax-deductible plan for ... of the Board of LTC Financial Partners LLC (LTCFP), ...
Cached Medicine News:Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 2Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 3Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 4Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 5Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 6Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 7Health News:Symmetry Medical Reports Fourth Quarter and Full Year 2008 Financial Results 8Health News:Activity Against Drug-Resistant Pathogens is One of the Leading Attributes Influencing Physicians' Antibiotic Selection for the Treatment of Inpatient Community-Acquired Pneumonia 2Health News:Activity Against Drug-Resistant Pathogens is One of the Leading Attributes Influencing Physicians' Antibiotic Selection for the Treatment of Inpatient Community-Acquired Pneumonia 3Health News:Transcendental Meditation buffers students against college stress: Study 2Health News:Transcendental Meditation buffers students against college stress: Study 3Health News:Transcendental Meditation buffers students against college stress: Study 4Health News:Transcendental Meditation buffers students against college stress: Study 5Health News:The Walter and Eliza Hall Institute Announces the Next Director 2Health News:The Walter and Eliza Hall Institute Announces the Next Director 3Health News:The Walter and Eliza Hall Institute Announces the Next Director 4Health News:Nuvo's High Throughput Experimentation Platform Selected as 2009 Edison Award Finalist 2Health News:Nuvo's High Throughput Experimentation Platform Selected as 2009 Edison Award Finalist 3Health News:Long Term Care Insurance for Business Owners & Executives: Tax Benefits Often Overlooked 2
(Date:9/19/2014)... Mich. , Sept. 19, 2014  Diplomat, the ... of David Dreyer to the Board of ... independent director and will also serve as chair of ... almost 30 years of accounting, financial, compliance and operating ... Mr. Dreyer has served as chief financial officer, chief ...
(Date:9/19/2014)... 2014 According to market ... Mobile, Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, ... Rotary) & Geography - Global Trends & Forecast ... the lyophilization market on the basis of various ... of the market size of each of these ...
(Date:9/19/2014)... , Sept. 19, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... class collagenase-based products marketed as XIAFLEX ® in the ... that BioSpecifics, President, Tom Wegman , will present a ... in the Biotech Industry Conference. The presentation ... p.m. EDT at the Millennium Broadway Hotel in ...
Breaking Medicine Technology:David Dreyer Appointed to Diplomat Board of Directors 2Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2
... Fla., May 8, 2012 Grappling with economic uncertainty, ... industry is on the cusp of major changes, said ... opening session of the 2012 GHX Healthcare Supply Chain ... GPOs and distributors gathered this week in Orlando for ...
... DIEGO, May 8, 2012 Aethlon Medical, Inc. ... filtration devices to address infectious disease, cancer and other ... C virus (HCV) is currently undetectable in all infected ... in combination with peginterferon+ribavirin (PR) drug therapy and monitored ...
Cached Medicine Technology:GHX Reveals Roadmap to Stronger Healthcare Community at GHX Healthcare Supply Chain Summit 2GHX Reveals Roadmap to Stronger Healthcare Community at GHX Healthcare Supply Chain Summit 3Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 2Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 3Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 4Aethlon Medical Reports Undetectable Hepatitis C Virus (HCV) in Genotype 1, Genotype 3, and Genotype 5 Patients Treated with Hemopurifier® Therapy 5
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: