Navigation Links
Duke receives new grant for AIDS vaccine research
Date:7/18/2012

DURHAM, N.C. -- The Bill & Melinda Gates Foundation has awarded a new grant to Duke University Medical Center for work developing vaccines that can induce IgA antibodies for preventing HIV-1 infection. This award comes from the Gates' Collaboration for AIDS Vaccine Discovery (CAVD) program.

Late in 2011, Duke also won three grants from CAVD that totaled $37.2 million.

The latest grant award is a 3-year, $8.9 million grant to Barton Haynes, M.D., a national leader in AIDS/HIV research and director of the Center for HIV/AIDS Vaccine Immunology (CHAVI), as well as director of the Duke Human Vaccine Institute (DHVI).

The award stems from promising discoveries from the analysis of the how a partially effective HIV-1 vaccine might have worked, that was carried out under Dr. Haynes' leadership. Haynes led a multinational group that analyzed a wealth of data from the RV144 trial in Thailand, which tested a combination vaccine for efficacy.

"We are grateful to the Gates Foundation and its Collaboration for AIDS Vaccine Discovery for their continued support that lets us explore important new findings," said Haynes, who is Frederic M. Hanes Professor of Medicine and Immunology at Duke. "We believe the latest analyses are yielding critical information, and we are poised to move into promising new phases of studies for vaccine development in the fight against AIDS."

This CAVD award will fund research into ways to induce protective IgA human antibodies by vaccines to prevent HIV-1 infection, as well as to learn how to not induce IgA antibodies that might block the protective effect of other antibodies. In learning how to induce the right IgAs, recombinant IgAs will be produced to be tested as therapies to prevent HIV.

The new award will support work to elaborate on studies recently completed by Haynes and his Duke colleague Georgia Tomaras, Ph.D., who found that IgA was induced in plasma in the RV144 HIV prevention trial. Tomaras showed that one type of IgA induced by the RV144 vaccine could possibly reduce the effects of other types of potentially protective antibodies that might limit the rate of infection.

With the CAVD grant, the researchers hope to develop strategies to induce forms of IgA with anti-HIV-1 activity at the sites of transmission of HIV, and to perform studies in non-human primates using differing types of IgAs and IgA-inducing immunogens to determine protection levels against HIV infection.

Dr. Haynes' other recent CAVD grant, awarded late in 2011, is funding studies of the best way to create effective immunogens that mimic the proteins on the HIV outer envelope for induction of another type of antibody, called IgG. The immunogens will work to stimulate the right IgG antibodies to prevent virus transmission. The grant will provide $11.7 million over three years.

Haynes will work closely with a team led by David Montefiori, Ph.D., professor of surgery and director of the Laboratory for AIDS Vaccine Research and Development in the Duke Department of Surgery. The Gates Foundation in December 2011 awarded a 5-year, $24.6 million CAVD grant to Montefiori and his collaborators to develop laboratory tests for the study of future vaccine trials as well as to work with other CAVD teams and learn how to induce protective antibodies.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. MCG student receives national medical honor society research fellowship
2. Gladstones Lennart Mucke receives Lifetime Achievement Award from the Alzheimers Association
3. JHU Bioethics Institute receives PCORI pilot project award
4. SUNY Downstate receives award to develop mobile phone apps for stroke patients and their caregivers
5. Einstein receives nearly $5 million to study how Ebola causes infection
6. Eye doctor receives Visionary Award
7. Cuff Repair Plate™ Receives Design and Utility Patents
8. Special Needs Spotlight: Former SFMTA Board Member Bruce Oka Receives Treatment with San Francisco Sedation Dentist Dr. David Blende
9. Clifford Saper, MD, PhD, receives Distinguished Scientist Award from the Sleep Research Society
10. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
11. Aging Brain Care model receives $7.8 million in CMS innovation funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to ... Elite division on February 12th. Ms. Esparza qualified into this prestigious status ... competition held in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, the most award-winning ... Gran Fondo of Marin. For the second year in a row, cyclists will ... , “We are thrilled to provide our safe, non-toxic sunscreen to over 2,000 ...
(Date:2/23/2017)... ... ... The 89th Academy Awards will be celebrated this weekend, which means it’s ... Award. We invite you to enjoy our 11th annual tongue-in-cheek “salute” to the shoddiest ... for American Progress (CAP), for its report, Lessons From State Performance on NAEP: Why ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... a clinician-based audience, will be participating in Rare Disease Day events, hosted by ... In addition, Rare Disease Report, a website, weekly e-newsletter and quarterly publication, will ...
(Date:2/23/2017)... ... , ... Los Angeles-based weight loss surgeon Michael Feiz, M.D., F.AC.S. will be ... Hot,” which will begin airing on February 24, 2017. The show chronicles the weight ... reality television series, “Here Comes Honey Boo Boo.” The earlier series from TLC lasted ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 24, 2017 Research and Markets has announced the ... Industry Forecast to 2025" report to their offering. ... The Global Empty Capsules Market is poised ... to reach approximately $2.9 billion by 2025. This industry ... on global as well as regional levels presented in the research scope. ...
(Date:2/24/2017)... HARRISBURG, Pa. , Feb. 24, 2017 ... Secretary of Drug and Alcohol Programs Jennifer Smith ... role in providing training for and using naloxone, a ... Mark McCullough , a recovery specialist and overdose ... naloxone by EMS providers. "A significant part ...
(Date:2/24/2017)... Juan Monteverde , founder and managing ... boutique securities firm headquartered at the Empire State Building ... that a class action lawsuit has been filed in the ... Inotek Pharmaceuticals Corporation (NASDAQ:  ITEK)("Inotek" or the "Company") on ... 2015 and December 30, 2016, inclusive (the "Class Period").  ...
Breaking Medicine Technology: