Navigation Links
Duke receives new grant for AIDS vaccine research
Date:7/18/2012

DURHAM, N.C. -- The Bill & Melinda Gates Foundation has awarded a new grant to Duke University Medical Center for work developing vaccines that can induce IgA antibodies for preventing HIV-1 infection. This award comes from the Gates' Collaboration for AIDS Vaccine Discovery (CAVD) program.

Late in 2011, Duke also won three grants from CAVD that totaled $37.2 million.

The latest grant award is a 3-year, $8.9 million grant to Barton Haynes, M.D., a national leader in AIDS/HIV research and director of the Center for HIV/AIDS Vaccine Immunology (CHAVI), as well as director of the Duke Human Vaccine Institute (DHVI).

The award stems from promising discoveries from the analysis of the how a partially effective HIV-1 vaccine might have worked, that was carried out under Dr. Haynes' leadership. Haynes led a multinational group that analyzed a wealth of data from the RV144 trial in Thailand, which tested a combination vaccine for efficacy.

"We are grateful to the Gates Foundation and its Collaboration for AIDS Vaccine Discovery for their continued support that lets us explore important new findings," said Haynes, who is Frederic M. Hanes Professor of Medicine and Immunology at Duke. "We believe the latest analyses are yielding critical information, and we are poised to move into promising new phases of studies for vaccine development in the fight against AIDS."

This CAVD award will fund research into ways to induce protective IgA human antibodies by vaccines to prevent HIV-1 infection, as well as to learn how to not induce IgA antibodies that might block the protective effect of other antibodies. In learning how to induce the right IgAs, recombinant IgAs will be produced to be tested as therapies to prevent HIV.

The new award will support work to elaborate on studies recently completed by Haynes and his Duke colleague Georgia Tomaras, Ph.D., who found that IgA was induced in plasma in the RV144 HIV prevention trial. Tomaras showed that one type of IgA induced by the RV144 vaccine could possibly reduce the effects of other types of potentially protective antibodies that might limit the rate of infection.

With the CAVD grant, the researchers hope to develop strategies to induce forms of IgA with anti-HIV-1 activity at the sites of transmission of HIV, and to perform studies in non-human primates using differing types of IgAs and IgA-inducing immunogens to determine protection levels against HIV infection.

Dr. Haynes' other recent CAVD grant, awarded late in 2011, is funding studies of the best way to create effective immunogens that mimic the proteins on the HIV outer envelope for induction of another type of antibody, called IgG. The immunogens will work to stimulate the right IgG antibodies to prevent virus transmission. The grant will provide $11.7 million over three years.

Haynes will work closely with a team led by David Montefiori, Ph.D., professor of surgery and director of the Laboratory for AIDS Vaccine Research and Development in the Duke Department of Surgery. The Gates Foundation in December 2011 awarded a 5-year, $24.6 million CAVD grant to Montefiori and his collaborators to develop laboratory tests for the study of future vaccine trials as well as to work with other CAVD teams and learn how to induce protective antibodies.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. MCG student receives national medical honor society research fellowship
2. Gladstones Lennart Mucke receives Lifetime Achievement Award from the Alzheimers Association
3. JHU Bioethics Institute receives PCORI pilot project award
4. SUNY Downstate receives award to develop mobile phone apps for stroke patients and their caregivers
5. Einstein receives nearly $5 million to study how Ebola causes infection
6. Eye doctor receives Visionary Award
7. Cuff Repair Plate™ Receives Design and Utility Patents
8. Special Needs Spotlight: Former SFMTA Board Member Bruce Oka Receives Treatment with San Francisco Sedation Dentist Dr. David Blende
9. Clifford Saper, MD, PhD, receives Distinguished Scientist Award from the Sleep Research Society
10. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
11. Aging Brain Care model receives $7.8 million in CMS innovation funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... this installment is bolstered by inspiring human interest stories, courtesy of leaders in ... trends and tech within the industry, from leading advocates and associations—namely Jones & ...
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports ... Yellen and company to wait until March 2017 for an interest rate increase, according ... Robinson College of Business. , “The Federal Open Market Committee (FOMC) dot charts are ...
(Date:5/26/2016)... ... May 26, 2016 , ... Intalere, the healthcare ... suppliers for its inaugural Member Conference at the Paris Hotel in Las Vegas, ... operational health of America’s healthcare providers. , The conference was highlighted by the ...
(Date:5/26/2016)... ... ... The Woodlands at John Knox Village , Florida’s first Life Plan ... and healing, celebrated its grand opening, today. The Woodlands at John Knox Village is ... Staff. , “This is an incredibly fulfilling time for John Knox Village as we ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... solutions for drugs, biologics, consumer health and global clinical supply services, today announced ... to support the company’s continued investment and strategic growth plans in the Asia ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... -- TARE (Transarterial Radio-embolization) Using Yttrium-90 ... Overall Decreased Use of Hospital Resource ... healthcare company, has today announced the publication of ... ISPOR (International Society for Pharmacoeconomics and Outcomes Research), ... yttrium-90 glass microspheres is associated with cost savings ...
(Date:5/25/2016)... PARIS , May 25,2016 ... with the near-infrared Cellvizio platform for urological and ... MKEA, OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary ... important regulatory milestone in the US with the ... Food and Drug Administration (FDA). This new FDA ...
(Date:5/25/2016)... and GERMANTOWN, Maryland , May ... QGEN ; Frankfurt Prime Standard: QIA) today announced that ... with Therawis Diagnostics GmbH to develop and commercialize predictive assays ... market PITX2 as a marker to predict effectiveness of anthracycline ... "We are pleased to partner with Therawis, which ...
Breaking Medicine Technology: