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Duke/Singapore scientists find new way to classify gastric cancers
Date:10/1/2009

and the Genome Institute of Singapore.

Investigators obtained 301 gastric tumors from three independent patient groups. They used computational methods to map the activation levels of 11 different cell signaling pathways already known to be active in the development of gastric cancer. They found that three pathways primary drivers of cell growth and death (NF-kappaB, Wnt/β-catenin and proliferation/stem cell) were deregulated in most of the tumors.

The researchers found that stratifying patients by single pathways did not predict outcomes, but stratifying them by combinations of pathways did.

"We feel that the ability to perform 'high-throughput pathway profiling' opens up a number of interesting possibilities, says Tan, who is also a member of the Institute of Genome Sciences & Policy at Duke University Medical Center. "It suggests that pathway combinations, rather than single pathways alone, may play a more critical role in influencing tumor behavior. We feel our findings that the NF-kappaB pathway may be especially important, because this pathway has been understudied in gastric cancer. Finally, our methods could certainly be used to study pathway profiles in other cancers, which could lead to new insight into tumor behavior and outcomes."


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Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

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