Navigation Links
Duke/Singapore scientists find new way to classify gastric cancers
Date:10/1/2009

DURHAM, N.C., -- An international team of scientists has discovered a new way to classify stomach cancers, and researchers say it may be an important step toward designing more effective treatments and improving long-term survival.

Stomach (gastric) cancer is particularly prevalent in Asia and represents the second leading cause of cancer deaths worldwide.

The research is based upon clinical findings from patients in Singapore, Australia and the United Kingdom and represents the largest genomic analysis of gastric cancers to date. The new system classifies gastric cancers by the signaling pathways the tumors use to grow and spread, as opposed to the more traditional approach that describes them by cell type or structure.

The findings, appearing online in the Public Library of Science journal PLoS Genetics, come from a group of scientists at the DukeNational University of Singapore Graduate Medical School in Singapore.

"We identified three oncogenic pathways that were activated in over 70 percent of the gastric tumors we examined," said lead author Chia Huey Ooi, PhD, Research Fellow in the Duke-NUS Graduate Medical School. "We also found that combinations of these pathways are significantly related to patient survival."

Stomach cancer is notoriously resistant to chemotherapy and newer biologic-based therapies have not proven very effective. With current treatments, less than a quarter of patients live longer than five years after surgery.

Study authors say the new classification system offers physicians the opportunity to stratify patients according to their tumors' pathway profiles and then apply the treatment that is designed to interrupt the signals those pathways use.

"These findings may give us the first way to truly offer our gastric cancer patients personalized medicine," says Patrick Tan, MD, PhD, the senior author of the study and a member of the Duke-NUS Graduate Medical School and the Genome Institute of Singapore.

Investigators obtained 301 gastric tumors from three independent patient groups. They used computational methods to map the activation levels of 11 different cell signaling pathways already known to be active in the development of gastric cancer. They found that three pathways primary drivers of cell growth and death (NF-kappaB, Wnt/β-catenin and proliferation/stem cell) were deregulated in most of the tumors.

The researchers found that stratifying patients by single pathways did not predict outcomes, but stratifying them by combinations of pathways did.

"We feel that the ability to perform 'high-throughput pathway profiling' opens up a number of interesting possibilities, says Tan, who is also a member of the Institute of Genome Sciences & Policy at Duke University Medical Center. "It suggests that pathway combinations, rather than single pathways alone, may play a more critical role in influencing tumor behavior. We feel our findings that the NF-kappaB pathway may be especially important, because this pathway has been understudied in gastric cancer. Finally, our methods could certainly be used to study pathway profiles in other cancers, which could lead to new insight into tumor behavior and outcomes."


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Scripps research scientists find missing puzzle piece of powerful DNA repair complex
2. Scientists decipher missing piece of first-responder DNA repair machine
3. University of Louisville neuroscientists hope to get people walking again
4. Oldest Skeleton in Human Family Tree Surprises Scientists
5. Scientists find obesity alone does not cause arthritis in animals
6. 2009 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
7. Scientists Discover How Chemo Can Make Women Infertile
8. Scientists May Know How Lung Cancer Spreads
9. UCSF scientists illuminate how microRNAs drive tumor progression
10. Glaxo Official Memo Urged Scientists to Withhold Information About Paxils Risks, Trial Hears; Pharmaceutical Industry Today Offers Complete News Coverage
11. University of Hawaii at Manoa CRCH scientists report adulthood body size associated with cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 26, 2016 One of Australia,s ... formation of a new biotechnology company, Noxopharm Limited [ABN 50 608 ... IPO and to list on the ASX. Noxopharm is ... to enter a Phase 1 clinical study later this year. ... one of the biggest problems facing cancer patients - the ability ...
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
Breaking Medicine Technology: