Navigation Links
Duke/Singapore scientists find new way to classify gastric cancers
Date:10/1/2009

DURHAM, N.C., -- An international team of scientists has discovered a new way to classify stomach cancers, and researchers say it may be an important step toward designing more effective treatments and improving long-term survival.

Stomach (gastric) cancer is particularly prevalent in Asia and represents the second leading cause of cancer deaths worldwide.

The research is based upon clinical findings from patients in Singapore, Australia and the United Kingdom and represents the largest genomic analysis of gastric cancers to date. The new system classifies gastric cancers by the signaling pathways the tumors use to grow and spread, as opposed to the more traditional approach that describes them by cell type or structure.

The findings, appearing online in the Public Library of Science journal PLoS Genetics, come from a group of scientists at the DukeNational University of Singapore Graduate Medical School in Singapore.

"We identified three oncogenic pathways that were activated in over 70 percent of the gastric tumors we examined," said lead author Chia Huey Ooi, PhD, Research Fellow in the Duke-NUS Graduate Medical School. "We also found that combinations of these pathways are significantly related to patient survival."

Stomach cancer is notoriously resistant to chemotherapy and newer biologic-based therapies have not proven very effective. With current treatments, less than a quarter of patients live longer than five years after surgery.

Study authors say the new classification system offers physicians the opportunity to stratify patients according to their tumors' pathway profiles and then apply the treatment that is designed to interrupt the signals those pathways use.

"These findings may give us the first way to truly offer our gastric cancer patients personalized medicine," says Patrick Tan, MD, PhD, the senior author of the study and a member of the Duke-NUS Graduate Medical School
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scripps research scientists find missing puzzle piece of powerful DNA repair complex
2. Scientists decipher missing piece of first-responder DNA repair machine
3. University of Louisville neuroscientists hope to get people walking again
4. Oldest Skeleton in Human Family Tree Surprises Scientists
5. Scientists find obesity alone does not cause arthritis in animals
6. 2009 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
7. Scientists Discover How Chemo Can Make Women Infertile
8. Scientists May Know How Lung Cancer Spreads
9. UCSF scientists illuminate how microRNAs drive tumor progression
10. Glaxo Official Memo Urged Scientists to Withhold Information About Paxils Risks, Trial Hears; Pharmaceutical Industry Today Offers Complete News Coverage
11. University of Hawaii at Manoa CRCH scientists report adulthood body size associated with cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... United Arab Emirates (PRWEB) July 12, 2014 ... another Los Angeles basketball legend is heading to the ... scorer and six-time champion will be in the UAE ... & Fitness Weekend in support of diabetes awareness. The ... an award-winning entertainment marketing and event management company based ...
(Date:7/12/2014)... Amarillo, Texas (PRWEB) July 12, 2014 ... and Breastfeeding Made Simple as a valuable new resource ... that roughly two-thirds of American women work away from ... many sources touting the benefits of breastfeeding, but often ... continuing to nurse their babies. With its evidence-based insights, ...
(Date:7/12/2014)... Restore My Vision Today is a new ... couple boasting very impressive credentials on the field of ... as a way to help consumers do without the ... respective patients’ treatments . , In particular, ... of pertinent information relevant to eye care like:, ...
(Date:7/12/2014)... 2014 Maxim Peptide, a website that ... used solely in scientific experiments, is currently celebrating its ... business, Maxim Peptide, which was created by the founders ... and updated website that now features a special deals ... updated with fascinating articles about peptide research, including a ...
(Date:7/12/2014)... 12, 2014 Ladies, it doesn't matter what ... Those who are looking for an affordable gown can ... occasion dresses) to get their dream items. Recently, the company ... length gowns . Along with that, it is also providing ... the special offer; the deadline of this promotion is July ...
Breaking Medicine News(10 mins):Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2
... of Northwestern University, is a super sleuth of potentially ... team of doctors called RADAR (Research on Adverse ... School of Medicine. They swoop in to investigate early ... Administration (FDA) takes notice. ,A new study ...
... Court on Friday announced that it has accepted a ... to review the constitutionality of a Mexico City law ... the first three months' gestation, the Los Angeles Times ... Democratic Revolution in March in the Mexico City Legislature ...
... such as Girls Aloud, Pussycat Dolls and the Sugababes have ... promoting an ideal for what a womans figure should look ... ,Researchers from the universities of Leeds and Sussex ... where all the band-members are skinny, found that watching such ...
... in Physiological and Biochemical Zoology, a fascinating new ... evolution and artificial selection, providing insight into ... fluctuations. ,Dr. James Hicks, Editor in ... collection of papers: "This exciting approach experimental ...
... good for the fairer sex, for a new study has found that ... as fast as if she has just had a grueling workout. ... a group of 35 women and found that trying on a pair ... beats per minute. ,And, this is not just a one ...
... up boozing from home. ,Based on this, ... away from their middle school children, the best place to ... by a team of researchers including principal investigator Kelli Komro ... Minnesota, Minneapolis. ,As part of the study, researchers ...
Cached Medicine News:Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 2Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 3Health News:Mexico Supreme Court Accepts Petition To Review Mexico City Law Legalizing Abortion During First Three Months' Gestation 2Health News:Research Throws Light on Adaptation of E.coli to Changing Conditions 2
(Date:7/11/2014)... July 11, 2014 Research and Markets ... and Chinese Medical X-ray Film Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 Global And Chinese Medical X-Ray ... study on the current state of the Global medical ... situation. The report provides a basic overview of ...
(Date:7/11/2014)... On Thursday, July 10, 2014, the NASDAQ ... Average finished the day 0.42% lower at 16,915.07, and the ... broad based as eight out of ten sectors ended the ... ended the day at 711.88, down 0.02%, while the index ... initiated coverage on the following equities: Covidien PLC (NYSE: ...
(Date:7/11/2014)... Neurelis, Inc. ("Neurelis") today announced an agreement ... held by Biotie to purchase Neurelis, clearing the way ... diazepam) for pediatric and adult epilepsy patients who experience ... Biotie has advanced the development program for NRL-1 and ... work required for NDA submission to the FDA.  Given ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
... includes three major components: Blood pump, Cannulae, ... Driver. This system provides partial or total ... conventional therapy, is unable to maintain adequate ... support, blood flows from the natural heart ...
Datascope presents a unique new product for post-hemostasis puncture site management. Safeguard is the first product ever to combine a built-in inflatable bulb and a sterile dressing- providing adjus...
... catheter is inserted into the subclavian or ... vena cava. The Cool Line incorporates ... temperature-controlled saline flowing within a closed-loop design, ... circulation. The Cool Line combines two ...
... The Fortius catheter provides maximum ... to target temperature. The Fortius catheter ... design to provide the ultimate solution ... catheter is inserted percutaneously into the ...
Medicine Products: