Navigation Links
Dual role: Key cell division proteins also power up mitochondria
Date:4/17/2014

(SACRAMENTO, Calif.) An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process. This is the first time the complex has been shown to perform both jobs. This newfound ability could make cyclin B1/Cdk1 an excellent target to control cellular energy production, potentially advancing cancer care and regenerative medicine. The research was published online today in the journal Developmental Cell.

"These proteins not only control the cell cycle, but they also moonlight to increase mitochondrial energy," said lead author Jian Jian Li, director of Translational Research at the UC Davis Comprehensive Cancer Center and professor in the Department of Radiation Oncology. "They synchronize these processes because the cell cycle cannot proceed without the extra energy."

The cyclin B1/Cdk1 complex has long been known to intervene at a critical point in the cell cycle, the G2 phase, during which cell division pauses after DNA replication to check for genetic damage. Once any damage has been repaired, the cell can move into mitosis (M) and begin dividing.

However, in addition to moving the cell cycle into mitosis, cyclin B1/Cdk1 also travels outside the nucleus to mitochondria the cell's power plants to boost energy production when the cell needs it most. Specifically, cyclin B1/Cdk1 phosphorylates (transfers energy to) a group of mitochondrial proteins (called complex I), increasing the organelles' ability to produce ATP, which powers most cellular activities. This coordination ensures the cell has enough energy to divide.

The team used both mouse and human cells, including breast cancer cells and normal human breast epithelial cells, to assess how cyclin B1/Cdk1controls mitochondrial energy metabolism during cell cycle G2/M progression. They found that increased mitochondrial protein phosphorylation by the cyclin B1/Cdk1 complex boosted energy production, while reversing that process reduced energy.

This is the first evidence that cyclin B1/Cdk1both senses the cell's energy needs during the G2/M transition and communicates that information to mitochondria. This mechanism could be an appealing therapeutic target for cancer.

"Under stress from radiation or chemotherapy, tumor cells may need mitochondria to provide extra energy to repair DNA damage," said Li. "If we block this communication between nucleus and mitochondria in tumor cells and inhibit glycolysis (directly converting glucose into cellular energy, the major cellular fuel for cancer cells), this could be a new approach to treating cancer."

In addition to making radiation and chemotherapy more effective, modulating cellular energy could potentially be used to control tumor growth.

"Like cars, tumors need a lot of gas," said Li. "If we reduce the amount of gas, we could perhaps slow down the cancer."

While inhibiting mitochondrial energy production could control tumors, boosting this process could help regenerative cells in normal tissues, such as muscle stem cells, repair damaged tissue, opening an entirely different therapeutic window.

Ironically, this newly discovered cellular mechanism could also boost communication between scientists, as this research unites two disciplines that had previously been separate: cell cycle and mitochondrial studies.

"A lot of people are working in mitochondria, and many more study the cell cycle, but few are studying the relationship between them," said Li. "In this paper, we show cross-talk between the nucleus and mitochondria. Now, perhaps, we can get similar cross-talk among experts between these two areas of study."


'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

Related medicine news :

1. Doctors Reluctant to Expand Nurse Practitioners Role: Survey
2. Oakworks Medical, a Division of Oakworks Inc., Oakworks.com, Manufacturer of Medical Tables and Positioning Devices Announces ISO 13485 Certification
3. Catalan researchers identify a key component of cell division
4. UMass Amherst cell biologists identify new protein key to asymmetric cell division
5. New form of cell division found
6. More sex for married couples with traditional divisions of housework
7. Stemedica Forms Cardiology Division. Sergey Sikora, PhD Appointed As Division President
8. Dr. Steve Carstensen Presents First Webinar for Dental Division of American Sleep and Breathing Academy
9. MDWebPro, a division of Digital Solutions, Inc. Releases "Healthcare Social Media Week in Review #HSCM: February 11, 2013
10. Rapid Insight New Hire Launches Healthcare Predictive Analytics Division
11. MDWebPro, a division of Digital Solutions, Inc. Releases Information About a New Addition to the MDWebPro Team, Tyler Weber, Public Relations Director
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... W.S. Badger Co. Inc ., the ... has been recognized as one of the best small businesses for new dads by ... of nine small businesses providing progressive benefits to new parents on the organization’s ...
(Date:5/27/2016)... ... , ... With over 60 percent of acute stroke survivors being left unable ... aid in the rehabilitation process has steadily increased. Ekso Bionics had been working to ... to stroke. , Ekso Bionics has now received clearance from the U.S. Food and ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... readers, this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities ... within the industry, from leading advocates, associations and industry leaders such as Bioness. ...
(Date:5/27/2016)... , ... May 27, 2016 , ... Beleza Medspa ... body fat composition regulations. This is the first time that Coolsculpting is being ... at least every six months to ensure they meet the prescribed body-fat standard, measured ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and ... stories, which come courtesy of leaders in the nursing and health care industry. It ... advocates and associations—namely Abilene Christian University. , As the nursing industry is coming ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... MedDay, a biotechnology company focused on the treatment ... "High doses of biotin in progressive multiple sclerosis: extension phase ... Ayman Tourbah , Principal Investigator of the Phase 3 ... Neurology (EAN) in Copenhagen, Denmark . The ... on Sunday, 29 May 2016 from 14:45 to 16:15 CEST ...
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
(Date:5/24/2016)... 24, 2016 Cirujanos holandeses han ... a los médicos a compartir sus mejores prácticas por ... mundial. Profesionales médicos de Europa, África, Asia ... a la aplicación, que combina la transmisión en vivo ... seguro. Educación   "Imagine un médico ...
Breaking Medicine Technology: