Navigation Links
Dual functions of gene revealed, for better and for worse

Researchers at WEHI have pinpointed the function of a potent cancer gene.

The gene, known as ERG, has long been associated with a range of human malignancies, including leukemia and sarcoma. American scientists showed in 2005 that ERG is mutated in more than half of all prostate cancers.

It was unclear, however, what function ERG normally performs in the human body and why it is so carcinogenic when mutated.

The team at WEHI has now demonstrated that ERGs usual role is to regulate the activity of blood stem cells. Without ERG, these cells cannot divide normally and the body fails to generate the trillions of blood cells that required each day to carry oxygen and fight infection.

The study suggests that ERG causes cancer by convincing normal cells to behave like stem cells, triggering unrestrained growth and expansion.

The findings offer hope that the targets of ERG might now be open to identification, which in the future might lead to new drugs that shut down the proliferation of cancer cells.


Contact: Brad Allan
Research Australia

Page: 1

Related medicine news :

1. Medical Affairs: Building Efficient Medical Affairs Functions That Drive Product Marketing Success
2. HR Under the Microscope: Metrics to Drive Costs Down Across HR Functions
3. Manufacturing Organizations Identify Efficiencies in Credit and Collections Functions
4. Manufacturing Organizations Identify Efficiencies in Maintenance Functions
5. Barr Announces Reorganization of Senior Management, Business Functions
6. Using HR Performance Metrics to Drive Costs Down Across HR Functions
7. Performance Metrics -- Market Research Structure and Functions
8. Language centers revealed, brain surgery refined with new mapping
9. Key factor in brain development revealed, offers insight into disorder
10. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
11. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
Post Your Comments:
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. ... articles published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... , June 24, 2016  American Respiratory Labs (ARL), a ... now able to perform sophisticated lung assessments in patients, homes, thanks ... Inc. Patients are no longer limited to having ... PRO ® , ARL patients like Jeanne R. of ... the comfort of her own home. ...
Breaking Medicine Technology: