Navigation Links
Dual effect on tumor blood vessels
Date:5/31/2012

As soon as they have grown to pinhead size, tumors rely on the formation of new blood vessels a process which is scientifically called angiogenesis. Interfering with this process (antiangiogenesis) is considered to be a promising approach in cancer medicine. However, those drugs that are already available for preventing the sprouting of new blood capillaries have failed to fulfill the high expectations placed on them.

Medical researchers hope to increase the efficacy of antiangiogenic therapies by attacking angiogenesis from several angles. Currently available antiangiogenic drugs are directed against the VEGF growth factor, which induces the sprouting of new blood vessels. However, other important players in angiogenesis include two signaling molecules called angiopoietin-1 and angiopoietin-2. Ang-1 is responsible for vascular maturation, while Ang-2 is a functional antagonist of Ang-1. Both signaling molecules bind to the same receptor, Tie-2, on the surface of endothelial cells.

"There are already studies showing that Ang-2 is a suitable target of new therapies directed against the blood supply of tumors. Combinations with already approved antiangiogenic drugs are regarded as particularly promising," says Prof. Dr. Hellmut Augustin, whose working groups are located at DKFZ and at Medical Faculty Mannheim of the University of Heidelberg. "However, as the role of Ang-2 was not entirely clear yet, we first needed to gain a better understanding of its molecular mechanism of action."

The scientists in Augustin's group have now found out that epithelial cells at the tip of sprouting capillaries produce large amounts of Ang-2, but not its known receptor, Tie-2. Nevertheless, these cells respond to the signaling molecule. This has prompted researchers to conclude that Ang-2 may also be able to mediate signals to epithelial cells via other surface molecules than Tie-2.

Indeed, the team of vascular experts found in the tip cells of newly sprouting capillaries that Ang-2 can use what are called integrins as alternative receptors. Integrins are membrane proteins common in many cell types, which are involved in many intercellular signaling processes.

"That means that we are dealing with two independent effects," Hellmut Augustin explains. "On the one hand, the already known function as an antagonist of Ang-1 in epithelial cells which produce the Tie-2 receptor and, on the other, the integrin-dependent effect on the capillary tip cells which do not have Tie-2. This also explains why experimental therapies targeting Ang-2 are more successful than those targeting its known receptor, Tie-2. This finding shows that it is double worthwhile to further develop therapies against Ang-2. Thus, we can attack the formation of blood vessels in the tumor from two angles at once."


'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Drug May Ease Cognitive Effects of Huntingtons
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Gastric Banding Most Effective for Obese Teens
4. Neuroimaging study may pave way for effective Alzheimers treatments
5. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
6. YazTalk Warns Women of Life Threatening Side Effects
7. Charging less for more effective treatments could reduce health care costs while improving health
8. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
9. New drug for kidney transplant recipients effective in humans
10. ACR, SBI: Avon Survey Reveals Potentially Deadly Effects of USPSTF Mammography Recommendations
11. Two Sepsis Treatments Look Equally Effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... In the midst of making plans ... most important arrangement — planning a safe way of getting home after the festivities. ... Unfortunately, these celebrations often lead to drunk drivers on the roads who become involved ...
(Date:5/5/2016)... , ... May 05, 2016 , ... Is the part ... Mother’s Day just a few days away, it’s a good opportunity to raise awareness ... to the American Academy of Dermatology, 40% of women experience hair loss or ‘thinning’ ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... for blood and service orders. Blood suppliers and their hospitals use BloodHub ... “BloodHub serves 13,000 active users across 2,100 hospitals who use our platform to ...
(Date:5/5/2016)... Wisconsin (PRWEB) , ... May 05, 2016 , ... ... proud to announce that Dr. Julie Lombardo, PT, DPT, MA, OCS, WCS, has ... of the WPTA Private Practice Award. The WPTA Private Practice Award is awarded ...
(Date:5/4/2016)... ... May 05, 2016 , ... The talus is the part ankle ... falls, or traffic accidents can cause the talus bone to be fractured, and a ... In a first-of-its-kind procedure using 3D printing technology, internationally renowned orthopedic surgeon Dr. ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... CITY, Mo. , May 3, 2016 /PRNewswire/ ... Kansas Medical Center,s Institute for Advancing Medical Innovation ... and commercialize new drugs, diagnostics and medical devices. ... provides BioNovus Innovations with rights to license, develop ... "This partnership represents ...
(Date:5/3/2016)... 2016  Axiogenesis has acquired a major investment from Sino-German High-Tech Fund to further expand product development, strengthen its ... http://photos.prnewswire.com/prnh/20160503/362921 ... ... ... ...
(Date:5/3/2016)... 2016 ACME Markets, ... Delaware County Councilman Dave White ... all ACME pharmacies across Delaware ... and Prevention (CDC), naloxone has saved 26,463 lives nationwide over the ... Delaware County were authorized to administer naloxone to ...
Breaking Medicine Technology: