Navigation Links
Dual effect on tumor blood vessels
Date:5/31/2012

As soon as they have grown to pinhead size, tumors rely on the formation of new blood vessels a process which is scientifically called angiogenesis. Interfering with this process (antiangiogenesis) is considered to be a promising approach in cancer medicine. However, those drugs that are already available for preventing the sprouting of new blood capillaries have failed to fulfill the high expectations placed on them.

Medical researchers hope to increase the efficacy of antiangiogenic therapies by attacking angiogenesis from several angles. Currently available antiangiogenic drugs are directed against the VEGF growth factor, which induces the sprouting of new blood vessels. However, other important players in angiogenesis include two signaling molecules called angiopoietin-1 and angiopoietin-2. Ang-1 is responsible for vascular maturation, while Ang-2 is a functional antagonist of Ang-1. Both signaling molecules bind to the same receptor, Tie-2, on the surface of endothelial cells.

"There are already studies showing that Ang-2 is a suitable target of new therapies directed against the blood supply of tumors. Combinations with already approved antiangiogenic drugs are regarded as particularly promising," says Prof. Dr. Hellmut Augustin, whose working groups are located at DKFZ and at Medical Faculty Mannheim of the University of Heidelberg. "However, as the role of Ang-2 was not entirely clear yet, we first needed to gain a better understanding of its molecular mechanism of action."

The scientists in Augustin's group have now found out that epithelial cells at the tip of sprouting capillaries produce large amounts of Ang-2, but not its known receptor, Tie-2. Nevertheless, these cells respond to the signaling molecule. This has prompted researchers to conclude that Ang-2 may also be able to mediate signals to epithelial cells via other surface molecules than Tie-2.

Indeed, the team of vascular experts found in the tip cells of
'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Drug May Ease Cognitive Effects of Huntingtons
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Gastric Banding Most Effective for Obese Teens
4. Neuroimaging study may pave way for effective Alzheimers treatments
5. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
6. YazTalk Warns Women of Life Threatening Side Effects
7. Charging less for more effective treatments could reduce health care costs while improving health
8. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
9. New drug for kidney transplant recipients effective in humans
10. ACR, SBI: Avon Survey Reveals Potentially Deadly Effects of USPSTF Mammography Recommendations
11. Two Sepsis Treatments Look Equally Effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... 2015 Getting patients to work with ... is critical to achieving the “triple aim” of better ... this will require a shift in thinking from stakeholders ... health systems move beyond their traditional boundaries to reach ... the third live meeting of the ACO and ...
(Date:5/4/2015)... The American Telemedicine Association (ATA) today released an ... gaps in coverage and reimbursement, and physician practice standards ... Gaps Reports last September, many state regulating bodies responded ... healthcare delivery in their state,” said Jonathan Linkous, CEO ... the nation, ATA reevaluated the indicators for each state ...
(Date:5/4/2015)... 2015 The U.S. healthcare worker shortage ... the ranks of senior citizens (1) and 27 million ... over-burdened healthcare system. Additionally, as older healthcare employees retire, ... Per the U.S. Census Bureau, the number of American ... by 2050 while those 25 to 54 will likely ...
(Date:5/4/2015)... 04, 2015 Los Angeles dental ... a more comfortable and attractive alternative for patients with ... for those who have lost teeth. Unfortunately, they also ... or slip at the worst possible moment and may ... They can also painfully pinch or rub gums, leaving ...
(Date:5/4/2015)... Pricing Healthcare announces it will ... patient receiving care at St. George Surgical Center ... be performed by July 15th, 2015, and the patient must ... front and forego the filing of insurance claims). , The ... year, and it devastates more and more individuals and families. ...
Breaking Medicine News(10 mins):Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 2Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 3Health News:AJMC’s ACO Coalition Explores the New Rules of Patient Engagement 4Health News:American Telemedicine Association Delivers New State Report Cards on Telemedicine 2Health News:American Telemedicine Association Delivers New State Report Cards on Telemedicine 3Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 2Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 3Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 4Health News:Los Angeles Dental Implants Doctor, Kevin Sands DDS, Now Offers a More Comfortable and Aesthetically-Pleasing Solution to Denture-Wearers 2Health News:Pricing Healthcare to Pay a Patient's Bill for a Procedure at Utah Facility 2Health News:Pricing Healthcare to Pay a Patient's Bill for a Procedure at Utah Facility 3
... offers pet owners the keys to stress-free travel with your ... families hit the road for a getaway. For those ... a stress-free holiday and a trip filled with anxiety for ... ) is dedicated to providing pet owners the tools ...
... (OTC Bulletin Board: GXXFF; TSX-V; GXX) ... a non-profit entity called Gold Star Humanitarian Society as ... the social welfare of the Liberian people throughout its ... Basins of south coastal Liberia. GXX, based in Vancouver, ...
... an emerging mind-body technique that produces measurable changes in ... practice. , The practice -- integrative body-mind training (IBMT) ... 1990s in China, where it is practiced by thousands ... involved in research on the method at the University ...
... A new Deloitte study profiling the comparative effectiveness ... Germany was released today at the 2009 BIO ... the report, available at www.deloitte.com/us/comparativeeffectivenessreport ... has the potential to improve care and reduce ...
... line to provide sun protection, laughs and college ... Today non-profit Cancer for College launches a ... All proceeds from the sunscreen sales will go ... in granting college scholarships to cancer survivors and ...
... Inc., headquartered in Orlando, FL, a leading provider ... predictive analytics, announced today that its solutions are ... the Centers for Medicare & Medicaid Services mandate, ... a medication therapy management (MTM) program.MEDai,s solutions ...
Cached Medicine News:Health News:Top 10 Pet Travel Tips for Memorial Day 2Health News:Gold Star Resources Corp. Launches Humanitarian Society to Aid Liberian People 2Health News:Of body and mind, and deep meditation 2Health News:Of body and mind, and deep meditation 3Health News:Deloitte Comparative Effectiveness Study Evaluates Potential Savings Opportunities for U.S. Health Care System 2Health News:Deloitte Comparative Effectiveness Study Evaluates Potential Savings Opportunities for U.S. Health Care System 3Health News:Deloitte Comparative Effectiveness Study Evaluates Potential Savings Opportunities for U.S. Health Care System 4Health News:Deloitte Comparative Effectiveness Study Evaluates Potential Savings Opportunities for U.S. Health Care System 5Health News:Photos: Will Ferrell Sunscreen to Launch Just in Time for Summer 2Health News:MEDai Helps Medicare Part D Sponsors Adhere to CMS Medication Therapy Management Initiative 2
(Date:5/4/2015)... -- Eli Lilly and Company (NYSE: LLY ) ... comprehensive overview of the company,s corporate responsibility efforts. ... approach to corporate responsibility by increasingly leveraging its ... have greater, more sustainable impact. The ... thorough look at the company,s progress on numerous ...
(Date:5/4/2015)... NASHVILLE, Tenn. , May 4, 2015  Verus ... after its acquisition of CPAP Care Club in 2012.  ... CPAP business within the durable medical equipment (DME) industry ... apnea patients for their CPAP supply needs and processes ... we bought this company three years ago, the systems ...
(Date:5/4/2015)... , May 4, 2015 CytoSorbents ... company commercializing its CytoSorb® extracorporeal cytokine adsorber to ... countries worldwide, will report Q1 2015 financial results ... 2015.  CytoSorbents, management will host ... will recount both operational and financial progress during ...
Breaking Medicine Technology:Lilly Releases Corporate Responsibility, Global Health Reports 2Lilly Releases Corporate Responsibility, Global Health Reports 3Lilly Releases Corporate Responsibility, Global Health Reports 4Verus Healthcare Celebrates 1,000% Growth on Third Anniversary 2CytoSorbents to Report Q1 2015 Operating and Financial Results 2CytoSorbents to Report Q1 2015 Operating and Financial Results 3
... for maintaining a healthy immune systemPURCHASE, N.Y., Jan. 6 ... Cancer (60(5), 643-651) by researchers at Kansai Medical ... Hexose Correlated Compound) enhances immune function by increasing the ... part of the immune system responsible for presenting foreign ...
... 6 Pacira Pharmaceuticals, Inc., an,acute care specialty ... in two pivotal Phase III SIMPLE trials to ... administration of EXPAREL(TM),(DepoBupivacaine) for prolonged postoperative analgesia. , ... in hemorrhoidectomy and in total knee,arthroplasty (TKA) are ...
Cached Medicine Technology:Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells 2Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells 3Phase III Studies of EXPAREL(TM) (DepoBupivacaine) from Pacira Complete Enrollment 2Phase III Studies of EXPAREL(TM) (DepoBupivacaine) from Pacira Complete Enrollment 3
The FetalSAT™ System with DualSens Sensor displays continuous, real-time fetal pulse oximetry (FSpO2) and fetal pulse rate (FPR) values in one compact monitor....
The reliable and easy-to-use 3800 pulse oximeter is now more advanced - featuring TruTrak+ technology, the proprietary clinical motion algorithm from Datex+-Ohmeda....
Rad-9™...
The Avant® 9700 combines flexible alarm options, unparalleled non-volatile memory, and Nonins time-honored technology to give you an easy-to-use and efficient monitor....
Medicine Products: