Navigation Links
Drunk behavior -- a question of immunity

University of Adelaide researchers have found that immune cells in your brain may contribute to how you respond to alcohol.

Lead researcher Dr Mark Hutchinson, ARC Research Fellow with the University's School of Medical Sciences, said his team's research provided new evidence that an immune response in the brain was involved in behavioural responses to alcohol.

This immune response lies behind some of the well-known alcohol-related behavioural changes, such as difficulty controlling the muscles involved in walking and talking.

"It's amazing to think that despite 10,000 years of using alcohol, and several decades of investigation into the way that alcohol affects the nerve cells in our brain, we are still trying to figure out exactly how it works," says lead researcher Dr Mark Hutchinson from the University's School of Medical Sciences.

"Alcohol is consumed annually by two billion people world-wide with its abuse posing a significant health and social problem," said Dr Hutchinson. "Over 76 million people are diagnosed with an alcohol abuse disorder.

"This work has significant implications for our understanding of the way alcohol affects us, as it is both an immunological and neuronal response. Such a shift in mindset has significant implications for identifying individuals who may have bad outcomes after consuming alcohol, and it could lead to a way of detecting people who are at greater risk of developing brain damage after long-term drinking."

The research is published in the latest edition of the British Journal of Pharmacology by PhD student Yue Wu, supervisor Dr Hutchinson, and others. Laboratory mice were given a single shot of alcohol and the researchers studied the effect of blocking toll-like receptors, a particular element of the immune system, on the behavioural changes induced by alcohol.

The researchers studied the effects of blocking the receptors by drugs, and also the effects of giving alcohol to mice that had been genetically altered so that they were lacking the functions of the selected receptors.

"The results showed that blocking this part of the immune system, either with the drug or genetically, reduced the effects of alcohol," Dr Hutchinson said. He believes similar treatment could work in humans.

"Medications targeting this specific receptor ‒ toll-like receptor 4 ‒ may prove beneficial in treating alcohol dependence and acute overdoses," Dr Hutchinson said.


Contact: Dr. Mark Hutchinson
University of Adelaide

Related medicine news :

1. Labor Day Drunk Driving Crackdown Planned
2. Research study reveals profile for female drunk-drivers
3. One in 12 Fans Leaves Major Sports Events Drunk: Study
4. 40 Million in U.S. Driving Drunk or Drugged
5. Why drunk drivers may get behind the wheel
6. People who suppress anger are more likely to become violent when drunk
7. 1 in 5 College Students Admitted to Drunk Driving, Study Found
8. More Young Women Driving Drunk
9. Sleepy Teens Prone to Bad Behaviors, Study Finds
10. Faster progress through puberty linked to behavior problems
11. Healthy Behaviors Will Help You Live Longer: CDC
Post Your Comments:
(Date:11/25/2015)... Missouri (PRWEB) , ... November 25, 2015 , ... ... HEAL, will provide scholarships for people struggling with eating disorders as a result ... from the second annual event, held at Fox Run Golf Club in Eureka, ...
(Date:11/25/2015)... ... November 25, 2015 , ... An unlikely combination of recycled ... way for homeless people to have a more dignified and comfortable night’s sleep. ... they are repurposing plastic bags into sleeping mats for the homeless. The ...
(Date:11/25/2015)... Mateo, CA (PRWEB) , ... November 25, 2015 , ... ... in prizes were awarded to winners of the Create Real Impact awards. California ... creative expression to help stem the tide of distracted and reckless driving, the number ...
(Date:11/24/2015)... GA (PRWEB) , ... November 24, 2015 , ... Dr. ... to now offer laser services to many of his patients. Dr. Afferica now uses ... designed to reduce the amount of time the doctor uses other traditional cutting tools, ...
(Date:11/24/2015)... SAN FRANCISCO, CA (PRWEB) , ... November 24, ... ... launched half-cup sizes, has launched their Black Friday sale a week early, offering ... ThirdLove continues to transform the intimate apparel industry through both mobile fit technology ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... Investors"), pursuant to which BioLight and the New Investors ... Ltd. subsidiary ("IOPtima") via a private placement. The financing ... its innovative IOPtimate™ system used in the treatment of ... pathway process for the IOPtimate™ system with the U.S. ...
(Date:11/25/2015)... 25, 2015 --> ... eine Lizenz für das Patent über eine neue Hepatitis-B-Behandlung, ... ENS-Lyon innehaben, an Enyo Pharma vergeben haben. ... Leben gerufenen und von Edelris gemeinsam mit seinen Partnern ... Behandlungsziel für HBV identifiziert, und es wurden neue Inhaltsstoffe ...
(Date:11/24/2015)... Calif. , Nov. 24, 2015 /PRNewswire/ ... leader in non-invasive genetic testing and the ... that it will present at the 27 ... York on Wednesday, December 2, 2015 at 1:00 p.m. ET.  Matthew Rabinowitz, ... Company,s financial results, business activities and financial ...
Breaking Medicine Technology: