Navigation Links
Drunk behavior -- a question of immunity
Date:9/29/2011

University of Adelaide researchers have found that immune cells in your brain may contribute to how you respond to alcohol.

Lead researcher Dr Mark Hutchinson, ARC Research Fellow with the University's School of Medical Sciences, said his team's research provided new evidence that an immune response in the brain was involved in behavioural responses to alcohol.

This immune response lies behind some of the well-known alcohol-related behavioural changes, such as difficulty controlling the muscles involved in walking and talking.

"It's amazing to think that despite 10,000 years of using alcohol, and several decades of investigation into the way that alcohol affects the nerve cells in our brain, we are still trying to figure out exactly how it works," says lead researcher Dr Mark Hutchinson from the University's School of Medical Sciences.

"Alcohol is consumed annually by two billion people world-wide with its abuse posing a significant health and social problem," said Dr Hutchinson. "Over 76 million people are diagnosed with an alcohol abuse disorder.

"This work has significant implications for our understanding of the way alcohol affects us, as it is both an immunological and neuronal response. Such a shift in mindset has significant implications for identifying individuals who may have bad outcomes after consuming alcohol, and it could lead to a way of detecting people who are at greater risk of developing brain damage after long-term drinking."

The research is published in the latest edition of the British Journal of Pharmacology by PhD student Yue Wu, supervisor Dr Hutchinson, and others. Laboratory mice were given a single shot of alcohol and the researchers studied the effect of blocking toll-like receptors, a particular element of the immune system, on the behavioural changes induced by alcohol.

The researchers studied the effects of blocking the receptors by drugs, and also the effects of giving alcohol to mice that had been genetically altered so that they were lacking the functions of the selected receptors.

"The results showed that blocking this part of the immune system, either with the drug or genetically, reduced the effects of alcohol," Dr Hutchinson said. He believes similar treatment could work in humans.

"Medications targeting this specific receptor ‒ toll-like receptor 4 ‒ may prove beneficial in treating alcohol dependence and acute overdoses," Dr Hutchinson said.


'/>"/>

Contact: Dr. Mark Hutchinson
mark.hutchinson@adelaide.edu.au
61-466-304-980
University of Adelaide
Source:Eurekalert

Related medicine news :

1. Labor Day Drunk Driving Crackdown Planned
2. Research study reveals profile for female drunk-drivers
3. One in 12 Fans Leaves Major Sports Events Drunk: Study
4. 40 Million in U.S. Driving Drunk or Drugged
5. Why drunk drivers may get behind the wheel
6. People who suppress anger are more likely to become violent when drunk
7. 1 in 5 College Students Admitted to Drunk Driving, Study Found
8. More Young Women Driving Drunk
9. Sleepy Teens Prone to Bad Behaviors, Study Finds
10. Faster progress through puberty linked to behavior problems
11. Healthy Behaviors Will Help You Live Longer: CDC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... 2017 , ... STATEMENT OPPOSING PRESIDENT DONALD TRUMP’S 2018 BUDGET ... budget, “A New Foundation for American Greatness—President's Budget FY 2018,” because it is ... populations, undermines productivity, and destroys the social safety net needed by hardworking but ...
(Date:5/24/2017)... ... May 24, 2017 , ... Medic CE , a Career Step ... Pediatric Septic Shock” hosted by the Journal of Emergency Medical Services (JEMS). The free ... will be presented by Captain Rommie Duckworth, LP, a career fire captain as well ...
(Date:5/24/2017)... ... May 24, 2017 , ... Rob Lowe is a sought after actor, ... Television. “Informed” brings the public important topics from all aspects of life, and a ... and issues surrounding feet and ankles. , Podiatry is essential to people’s overall well-being, ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... (PVDF) based sleep diagnostics sensors, announced today it had completed the first phase ... a mix of domestic and rest of world (ROW) authorized dealers specializing in ...
(Date:5/23/2017)... NEW YORK, NY (PRWEB) , ... May 23, ... ... decision makers in the pharmaceutical and medical device sectors, today announced the winners ... • Transformers • Entrepreneurs) represent the most influential people in the healthcare industry ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... COTTAGE, N.Y. , May 22, 2017 /PRNewswire/ ... antiviral treatment Gene-Eden-VIR/Novirin, announces the launch of a ... plain English, the results of a clinical study ... one year treatment with Gene-Eden-VIR/Novirin in individuals suffering ... important to note that there are no other ...
(Date:5/15/2017)... ATLANTA , May 15, 2017  Amy Baxter ... the industry leader in noninvasive pain relief, was awarded ... MM&M magazine. Baxter was recognized at the MM&M ... New York City on May 10, ... helping the biopharma industry go "beyond the pill."  ...
(Date:5/10/2017)... MARLBOROUGH, Mass., May 10, 2017 Hologic, Inc. ... financial results for the fiscal second quarter ended April ... (EPS) of $1.84 increased 666.7% compared to the prior ... business resulted in a significant gain, while non-GAAP diluted ... increased 3.2%, or 3.8% in constant currency terms.  Excluding ...
Breaking Medicine Technology: