Navigation Links
Drugs warning -- check the label
Date:2/2/2011

A new study highlights inconsistencies in black box warnings - medication-related safety warnings on a drug's label - and argues for a more transparent and systematic approach to ensure these warnings are consistent across all drugs within a same category, and any additions to warnings, on the back of a drug withdrawal for example, are done within a reasonable and uniform time period. The work by Orestis Panagiotou and John Ioannidis and colleagues from the University of Ioannina School of Medicine in Greece and Stanford University School of Medicine in the USA is published in Springer's journal Journal of General Internal Medicine.

Black box warnings are the strongest medication-related safety warnings that can be placed in a drug's labelling information, according to the FDA. Their purpose is to highlight major drug-related risks. Because serious drug-related adverse events tend to be down to the pharmacological class of drug rather than to the individual drug, most black box warnings are typically applied to all members of a given class of drugs.

Panagiotou and team looked at how consistent black box warning labelling is across same-class drugs in order to assess whether some drugs fail to carry a warning when black box warnings exist for other drugs in the category, as well as whether there are differences in the time it takes to add a warning to drugs in the same class. They studied the labels of 20 drug classes (176 drugs in total) selected from the USA's 'Top 200 Drugs for 2008 by Sales'. Of these 20 categories, 10 had at least one black box warning while the other 10 had none.

The authors identified differences in 9 of the 20 classes, with 15 black box warnings not present on all the labels of drugs in the same class. For 10 of these 15 different warnings, the information was included elsewhere on the labels as simple warnings or text. For the remaining 5, the black box context was not found anywhere else on the drugs' labels. Significantly, withdrawn drugs tended not to have a black box warning before their withdrawal and the reason for their withdrawal rarely became a black box warning for the other drugs in the same category.

In addition, among the 10 drug classes with at least one warning, there was a considerable time-lag in black box warning acquisition in 8 categories, ranging from 2 months to 14 years in some cases.

The authors argue that labels should mention and justify why a major recognized risk is not an issue for a particular agent in the same class, where other members have demonstrated major toxicity. In their view, unjustified omission of a black box warning may leave patients largely unaware of potential risks.

Orestis Panagiotou and colleagues conclude: " Our findings imply that the process of black box warning acquisition requires transparent and systematic rules, as well as clear justification for the presence of, or lack of evidence for, specific major risks for individual drugs."


'/>"/>

Contact: Renate Bayaz
renate.bayaz@springer.com
49-622-148-78531
Springer
Source:Eurekalert  

Related medicine news :

1. Too Few Get Needed Rheumatoid Arthritis Drugs: Study
2. Smart lasers could make cancer biopsies painless, help speed new drugs to market
3. New Oral Drugs Hailed for Treating MS
4. Not All Heart Failure Drugs Boost Survival Equally
5. Epilepsy Drugs May Raise Fracture Risk in Older Adults
6. Drugs for hair loss and BPH may result in loss of libido, ED in men
7. Evidence lacking for widespread use of costly antipsychotic drugs, says Stanford researcher
8. Studies Decipher How Anti-Smoking Drugs Work
9. Structure of key molecule in immune system provides clues for designing drugs
10. Heartburn Drugs May Raise Pneumonia Risk
11. Trio of drugs may combat triple negative breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drugs warning -- check the label
(Date:2/20/2017)... PA (PRWEB) , ... February 20, 2017 , ... ... collaborating to help health care providers better manage patient health risks, foster behavior change ... medication video library in the world, will present a demonstration of its video capability ...
(Date:2/20/2017)... TX (PRWEB) , ... February 20, 2017 , ... ... is now offering a full range of emergency dental care at his office, ... and gums. When patients experience dental emergencies, they are at risk for serious ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new Swain ... is being led by Amelia Joseph, Ph.D. Joseph was engaged by the college as ... nursing department in early 2016. After a nation-wide search, she was selected to head ...
(Date:2/18/2017)... (PRWEB) , ... February 17, ... ... Change for Devicemakers , Sponsored by Axendia, **FDAnews Free Webinar**, March 1, ... Are manufacturers looking to reduce their regulatory burden? Pay dividends in enhanced ...
(Date:2/18/2017)... ... February 18, 2017 , ... ... Use Pixel Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line ... other applications. Users can pick and choose from hand-crafted trend-setting designs with ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... , Feb. 20, 2017   Orion Health ... its Amadeus precision medicine platform to the ... currently manages over 110 million patient records globally. ... developing cloud-based, big data solutions built on modern, scalable ... Healthcare and Life Sciences. "The AWS Cloud gives healthcare ...
(Date:2/20/2017)... , Feb. 20, 2017 Seal Shield ... health IT solution for mobile device management and disinfection, ... HIMSS Conference and Exhibition in Orlando, Fla. ... Mobile devices have become commonplace in today,s ... a new set of concerns, including the disinfection and ...
(Date:2/20/2017)... Feb. 20, 2017  There has been a paradigm ... (NCDs) across sub-Saharan Africa, which in turn is driving ... of more Western lifestyle diseases such as cardiovascular disease ... infectious and parasitic illness, will present the pharmaceutical industry ... opportunity of $40.8 billion in 2019. "An ...
Breaking Medicine Technology: