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Drugs used to treat lung disease work with the body clock
Date:7/27/2014

Scientists from The University of Manchester have discovered why medication to treat asthma and pneumonia can become ineffective.

The findings, published in Nature Medicine, show that drugs widely used to treat lung diseases work with the body clock.

In the UK pneumonia, which is caused by an infection, affects around 1 in 1000 adults each year and is more serious for babies, young children, the elderly, smokers and those with an underlying health condition.

More than 5 million people in the UK are affected by asthma and the NHS spends around 1 billion a year treating and caring for people with the disease.

The research, led by Professors David Ray and Andrew Loudon from The University of Manchester, found out that cells lining the lung airways have their own body clock which is the time-keeper for lung inflammation - both conditions cause swelling (inflammation) in the lungs.

And the team discovered that more severe lung inflammation happens as a result of the loss of the body clock working in these cells.

Professor Loudon said: "We found a key molecule known as CXCL5 that facilitates lung inflammation which is a key regulator of how immune cells get into tissues. The loss of CXCL5 completely prevents the time of day regulation of lung inflammation which opens up new ways to treat lung diseases."

During the research, the team uncovered how glucocorticoid hormones from the adrenal gland are vital in controlling the level of inflammation in the cells lining the airway.

Professor Ray said: "This hormone works through the glucocorticoid receptor, a major regulator of gene expression. We wanted to find out therefore if glucocorticoid medicines, like prednisolone or dexamethasone would also show a time of day effect, and our research shows they do."

The team concluded that the rhythm of the clock in the lining of the cells in the lungs is important for lung diseases like a
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Contact: Ali Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

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