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Drugs used to tackle hospital-acquired infections can increase post-op complications
Date:10/31/2011

The introduction of new antibiotic regimes to tackle hospital-acquired infections, such as C. difficile, must take into account the possibility of increased infections following specific surgical procedures. That is the key finding of a study published in the November issue of the urology journal BJUI.

UK researchers from Addenbrooke's Hospital, Cambridge discovered that patients undergoing a standard surgical procedure to diagnose prostate cancer developed more than five times as many infective complications when a new standard antibiotic regime was introduced.

These included a number of cases of sepsis and one case of septic shock, which they describe as a highly significant finding.

"The change, based on national guidance, reflected concerns that C. difficile rates were being driven by the widespread use of broad-spectrum antibiotics such as ciprofloxacin" explains departmental lead and senior author Professor David Neal. "The new regime was introduced on the proviso that both the hospital-acquired infection rates and post-operative infection rates would be closely monitored.

"Given that there were no cases of C. difficile recorded in our study, but post-operative infection rates increased significantly, the decision was taken to revert back to the original regime."

Records for 709 consecutive patients who received transrectal ultrasound-guided prostate biopsy surgery (TRUSP Bx) over a period of 20 months were studied. These showed that:

  • Only 2.4 per cent of the 454 patients treated with the original regime of prophylaxis with ciprofloxacin developed an infective complication within four weeks of surgery and four (0.9 per cent) were admitted for complications.

  • 12.9 per cent of the patients treated with the new regime of prophylaxis with co-amoxiclav and gentamicin developed an infective complication within four weeks of surgery. Twelve patients (4.7 per
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Contact: Annette Whibley
annette.wizard@gmail.com
Wiley-Blackwell
Source:Eurekalert

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