Navigation Links
Drugs used to tackle hospital-acquired infections can increase post-op complications
Date:10/31/2011

The introduction of new antibiotic regimes to tackle hospital-acquired infections, such as C. difficile, must take into account the possibility of increased infections following specific surgical procedures. That is the key finding of a study published in the November issue of the urology journal BJUI.

UK researchers from Addenbrooke's Hospital, Cambridge discovered that patients undergoing a standard surgical procedure to diagnose prostate cancer developed more than five times as many infective complications when a new standard antibiotic regime was introduced.

These included a number of cases of sepsis and one case of septic shock, which they describe as a highly significant finding.

"The change, based on national guidance, reflected concerns that C. difficile rates were being driven by the widespread use of broad-spectrum antibiotics such as ciprofloxacin" explains departmental lead and senior author Professor David Neal. "The new regime was introduced on the proviso that both the hospital-acquired infection rates and post-operative infection rates would be closely monitored.

"Given that there were no cases of C. difficile recorded in our study, but post-operative infection rates increased significantly, the decision was taken to revert back to the original regime."

Records for 709 consecutive patients who received transrectal ultrasound-guided prostate biopsy surgery (TRUSP Bx) over a period of 20 months were studied. These showed that:

  • Only 2.4 per cent of the 454 patients treated with the original regime of prophylaxis with ciprofloxacin developed an infective complication within four weeks of surgery and four (0.9 per cent) were admitted for complications.

  • 12.9 per cent of the patients treated with the new regime of prophylaxis with co-amoxiclav and gentamicin developed an infective complication within four weeks of surgery. Twelve patients (4.7 per cent) were admitted for complications.

  • Seven of the 12 patients readmitted after being treated with the new regime were admitted with sepsis - in which the bloodstream is overwhelmed by bacteria - and a further patient had septic shock, which required inotropic support for 24 hours. None of the patients on the original regime had these very serious complications.

  • None of the patients developed C. difficile within one month of receiving antibiotics.

  • Reintroducing the original regime led to a fall in infective complications.

"Even though TRUSP Bx is a common urological procedure there are currently no national guidelines regarding antibiotic prophylaxis and local protocols vary widely across the UK" says Professor Neal. "However, the importance of using prophylaxis for a biopsy, to reduce the occurrence of infective complications following surgery, has been well documented.

"This is the first study to compare the use of co-amoxiclav and gentamicin with the use of ciprofloxacin for TRUSP Bx. Patients given the original ciprofloxacin regime experienced significantly fewer infective complications than those on the new regime and this audit study supports the use of locally determined prophylactic regimes for this procedure."

The authors stress that antibiotic prophylaxis needs to reflect the local situation, both in terms of tissue penetration, the organisms encountered and their susceptibilities and the local C. difficile rates. They add that any changes also need to be subject to frequent review.

"Any alteration to existing departmental antibiotic policies should be linked to strong clinical evidence, because such changes may potentially result in significant ill health and potential harm, as well as the financial burden of treating new complications" concludes Professor Neal.


'/>"/>

Contact: Annette Whibley
annette.wizard@gmail.com
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Some People With Alzheimers Take Conflicting Drugs
2. Study indicates nanoparticles could help pain-relieving osteoarthritis drugs last longer
3. Many Alzheimers patients get drugs with opposing effects
4. Some Asthma Drugs Raise Risk of Complications, Especially in Kids: Study
5. New anti-inflammatory drugs might help avoid side effects of steroids
6. Double duty for blood pressure drugs: how they could revolutionize how we treat valve disease
7. Are acid-suppressing drugs prescribed too often in infants?
8. Hypertension, Not Blood Pressure Drugs, Linked to Birth Defects
9. Antiviral drugs may slow Alzheimers progression
10. Tests to catch the makers of dangerous legal high designer drugs
11. $8.4 million grant supports health information exchange and research on Alzheimers drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... VA (PRWEB) , ... May 26, 2017 , ... ... pleased to announce a new educational seminar to focus on current legislative activity ... News(LEARN) seminar will begin at 1 p.m. Sunday, Sept. 10, and will continue ...
(Date:5/26/2017)... Nevada (PRWEB) , ... May 26, 2017 , ... ... produce the first ever copper, antimicrobial, mesh back 24/7 task chair specifically designed ... conference applications. “We are thrilled to partner with Cupron® to provide customers ...
(Date:5/26/2017)... ... May 26, 2017 , ... Rob Lowe acts as host and helps ... series is on hiking in American. Viewers can reconnect with America as it explores ... hiking. , Many consumers have looked for an inventive new place for a family ...
(Date:5/26/2017)... ... ... of Eden”: retells the stories of three Bible figures in modern terms. “Just What ... trader, horse farmer, artist and a former GM journeyman. Born in 1953 in Portland, ... to Dayton, Ohio, where Penny graduated high school. At sixteen, she toured France to ...
(Date:5/24/2017)... New York, New York (PRWEB) , ... May 24, 2017 , ... ... and general vascular surgery in New York City. He is known for ... his broad specialization in vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... SAN DIEGO , May 4, 2017 ... 2017 Annual Clinical and Scientific Meeting— OBP Medical , ... devices, today announced the launch of a new extra-small ... and ER-SPEC vaginal specula. Already available ... and extra-large sizes makes OBP Medical,s line of single-use ...
(Date:5/4/2017)...  A new tight-tolerance microextrusion medical tubing product ... is being launched by Natvar, a Tekni-Plex company. ... recent years to service a wide variety of ... expensive materials such as glass and fluoropolymers have ... their ability to consistently hold tolerances. This is ...
(Date:5/3/2017)... , May 3, 2017 A Catheterization ... hospital or healthcare facility. Commonly referred to as ... equipped with diagnostic imaging technology to give physicians ... heart. In these spaces, a team of physicians ... angioplasty, percutaneous coronary intervention, congenital heart defect closure, ...
Breaking Medicine Technology: