Navigation Links
Drugs to treat cocaine abuse?
Date:8/10/2010

Philadelphia, PA, 10 August 2010 - The authors of a new study in Biological Psychiatry explore pharmacological strategies for reducing cocaine self-administration in animals that may have implications for treating cocaine dependence in humans.

Glutamate is the primary excitatory neurotransmitter in the brain, which has been implicated in drug addiction. Metabotropic glutamate receptors (mGluRs) represent a family of G-protein coupled receptors that modulate glutamate transmission. Glutamate is an important neurotransmitter involved in learning and memory. Today, these receptors are considered to be promising targets for drug discovery, with therapeutic potential to treat various neurological and psychiatric disorders, including drug addiction.

Scientists from The Scripps Research Institute examined whether dysregulation of mGluRs function is a factor in escalating cocaine self-administration in rats. Rats with a history of daily short (1 hour) or long (6 hours) access to cocaine were tested for differences in cocaine consumption after receiving treatment with LY379268, an mGluR2/3 agonist, and MTEP, an mGluR5 antagonist.

They found that the capacity of LY379268 and MTEP to diminish cocaine use changed into opposite directions during development to addiction. LY379268 became more effective, whereas MTEP lost its effect in cocaine dependent rats (long-access). These behavioral changes were paired with distinct changes in the function of mGlu2/3 and mGlu5 receptors.

Dr. Yue Hao, corresponding author of this study, explains their findings: "We provide novel evidence that during the transition from 'casual' cocaine use to addiction, dysregulation develops in both mGlu2/3 and mGlu5 function as reflected by enhanced mGlu2/3 activity and decreased mGlu5 expression." These data suggest that changes in the function of mGlu2 and mGlu5 receptors may play a role in the transition to cocaine addiction.

According to the
'/>"/>

Contact: Maureen Hunter
m.hunter@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Epilepsy Drugs Dont Raise Suicide Risk, Study Shows
2. Recession Causing Cancer Patients to Quit Life-Extending Drugs
3. New Data Supports Link Between Diabetes Drugs, Fractures
4. Popular diabetes drugs associated with fractures in type 2 diabetic patients
5. Not All Epilepsy Drugs Raise Suicide Risk: Study
6. Non-human sugar in biotech drugs causes inflammation
7. Most men in long-term study of HIV report low use of illicit drugs
8. Experts Issue New Guidelines on Breast Cancer Drugs
9. Drugs Like Viagra Linked to Higher Rates of STDs
10. Teen Girls Becoming More Open to Drugs, Alcohol
11. Breast milk transmits drugs and medicines to the baby
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... 31, 2015 , ... Intellitec Solutions announced they have reached a record for ... new staff member in 2015. With the potential for more hiring occurring before the ... Dynamics GP, Dynamics SL, Dynamics CRM and Intacct, and has hired new support staff ...
(Date:8/31/2015)... ... August 31, 2015 , ... healthbeautydistributors.com has been in business ... marketing a doctor note service to be made available to all patients and ... each generated excuse, much less than the average daily pay of workers. ...
(Date:8/30/2015)... California (PRWEB) , ... August 31, 2015 , ... Avid ... Morrison and the Doors Shrine Auditorium concert posters. This hand colored artwork is one ... and 23 in Los Angles. Hawley states, "When the doors played the Shrine, ...
(Date:8/30/2015)... ... 2015 , ... ChopChop Kids, the nonprofit publisher of the ... two new officers to serve on the organization’s Board of Directors in accordance ... kids to cook real food with their families and help continue to drive ...
(Date:8/30/2015)... ... ... Scientists in France say asbestos exposure may put workers at higher risk ... just posted an article on the new research. Click here to read it ... 2,024 French asbestos plant workers from 1978 to 2009. In addition to mesothelioma, the ...
Breaking Medicine News(10 mins):Health News:Intellitec Solutions Achieves Record Pace for New Hiring 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 3Health News:Researchers Say Mesothelioma Not the Only Cancer Linked with Asbestos Exposure, According to Surviving Mesothelioma 2
... in as the 5th Chair on "The Doctors", LOS ... be the guest co-host on the number one new syndicated,talk ... (check local,listings, http://www.thedoctorstv.com )., Best known from the ... York Times Bestselling Author for his book, Billion Dollar Smile,sits ...
... fatal parasite; first vaccines delivered following major funding award. ... that could eradicate a fatal form of brain disease ... soon be commercially available thanks to multi-million dollar funding. ... million tapeworm infections and 50,000 deaths from brain disease ...
... Abbott (NYSE: ABT ),will present at the 17th ... Thomas C. Freyman, executive vice president, finance,and chief financial ... 5,p.m. CST., A live audio webcast of the ... at http://www.abbottinvestor.com . An,archived edition of the presentation ...
... for stroke ... treatment, ... a team,of stroke experts from the West Virginia University Health Sciences ... The study showed CT perfusion had,100 percent accuracy for detecting the ...
... of America, Inc.,(OTC Bulletin Board: CPCF), a company ... in endovascular procedures, today announced,that it is implementing ... its MedClose(TM) investigational-stage medical device. In,the roll out ... Medical,Product Service GmbH (MPS) of Germany to act ...
... Emergency Room Life Through Eyes of Poet Doctor, ... care,crisis in America to the natural fear of illness ... wonder and poetry in medical practice.,Bertrand P. Fote has ... his,work as an emergency physician, and he captures this ...
Cached Medicine News:Health News:Celebrity Cosmetic Dentist to Guest Co-Host New National Day Time Talk Show 2Health News:Fight begins to eradicate fatal parasite; first vaccines delivered following major funding award 2Health News:Fight begins to eradicate fatal parasite; first vaccines delivered following major funding award 3Health News:West VA University Study Calls for New Method of Stroke Diagnosis 2Health News:West VA University Study Calls for New Method of Stroke Diagnosis 3Health News:West VA University Study Calls for New Method of Stroke Diagnosis 4Health News:CPC Appoints Medical Product Service GmbH as Authorized European Representative for MedClose(TM) System 2Health News:CPC Appoints Medical Product Service GmbH as Authorized European Representative for MedClose(TM) System 3Health News:Physician Portrays Powerful Poetry at Heart of Human Condition 2
(Date:8/28/2015)... Research and Markets ( ... "Investigation Report on China,s Ranibizumab Market, 2012-2019" report ... was approved by CFDA to treat wet age- related ... product of Novartis, is available in the Chinese market. ... drug for the treatment of wet AMD in ...
(Date:8/28/2015)... , Aug. 28, 2015 Perrigo Company ... on the Mylan N.V. ("Mylan") (NASDAQ: MYL ) ... Perrigo. "Our views of Mylan,s offer to ... be, based on our Board,s careful reflection of the ... on the limited choices that Mylan has allowed its ...
(Date:8/28/2015)... and PITTSBURGH , Aug. 28, ... today announced that its shareholders have approved Mylan,s ... PRGO ; TASE) and the related issuance of ... extraordinary general meeting of shareholders held today. The ... at the extraordinary general meeting. In addition, the ...
Breaking Medicine Technology:Investigation Report on China's Ranibizumab Market, 2012-2019 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9
... Inc. (DCI), announced that the company has received ... its New Drug Application (NDA) for PERTZYE™, indicated ... due to cystic fibrosis (CF) or other conditions.  ... enzyme product containing bicarbonate-buffered enteric-coated microspheres and is ...
... Inc. today announced that company personnel will deliver a ... Week (DDW) annual meeting at 9 a.m. PDT on ... Center in San Diego, California. DDW attracts thousands of ... share the latest research in gastrointestinal health topics, for ...
Cached Medicine Technology:Digestive Care, Inc. Announces FDA Approval of PERTZYE™ (pancrelipase) Delayed-Release Capsules 2Receptos to Deliver Scientific Presentation at Digestive Disease Week 2012 about the Therapeutic Role of RPC1063 in Inflammatory Bowel Disease 2
Trans-Blot Plus Gel/Cassette Assembly Tray...
Ice block will provide sufficient cooling for most normal blotting applications. Sealed block is held submerged in transfer buffer. Ice block will not spill during refreezing....
... Pens-Using a proprietary and patented technology, ADI ... called Antigen-Antibody pens-TM, that will allow researchers ... in any form or shape or size. ... to see antigen being written on the ...
... Advantages of using the Antigen-Antibody Pens-Using a ... and developed specialized fountain pens, called Antigen-Antibody ... or write/mark the blotting membranes in any ... formulated antigen-bonded colored dyes helps to see ...
Medicine Products: