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Drugs to bulk up muscles may make injuries more likely
Date:1/22/2008

ential of myostatin inhibitors to increase muscle mass.

For people with the most common forms of muscular dystrophy as well as muscle-wasting diseases, myostatin inhibitors represent one potentially effective type of treatment that is being explored. These inhibitors may be able to reverse the loss of muscle mass and also lessen fibrosis, a build-up of connective tissue in muscle that afflicts people with muscular dystrophy and can be a problem in aging and inactivity. One myostatin inhibitor is currently being tested in people as a possible treatment for Duchenne muscular dystrophy, a debilitating disease that affects one in 3,500 boys worldwide.

For certain types of competitive athletes, the possibility that tendons become stiffer with myostatin inhibitors may not seem a disadvantage, says Mendias, who is also an athletic trainer. The prospect of widespread interest in myostatin inhibitors for enhancing performance, which like steroid use is illegal, is very real, he says, adding that the study results point to a greater need for a system to detect their use.


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Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

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