Navigation Links
Drugs to Treat Lung Damage in Preemies May Harm Brain
Date:11/17/2008

Even when given before birth, glucocorticoids tied to cognitive, motor control problems in mice

MONDAY, Nov. 17 (HealthDay News) -- Glucocorticoid drugs used to treat chronic lung damage in premature infants caused brain injury in mice and may cause cognitive and motor control problems even when they're given before birth, according to researchers at Washington University School of Medicine in St. Louis.

They examined the effects of the synthetic glucocorticoids dexamethasone and betamethasone, which are given to premature babies to aid lung development. The drugs caused brain cell death when given to mice four and 10 days after birth. The damage occurred in the cerebellum, the brain structure that controls movement and other functions.

"The cells that are damaged are called neural progenitor cells, which are responsible for producing new neurons. So you can imagine that if you kill the cells responsible for producing new neurons, you can cause severe neurodevelopmental effects," study first author Kevin K. Noguchi, a scientist in the department of psychiatry, said in a university news release.

That's what Noguchi and colleagues found when they examined adolescent mice that were given glucocorticoids during infancy. A single exposure to glucocorticoids permanently decreased the number of neurons in the cerebellum.

"The cerebellum connects to other brain structures, so when granule cells in the cerebellum are lost, you also have detrimental effects on cognitive function in non-motor regions of the brain. Other researchers have found IQ declines in children who have received these drugs early in life, and our findings may help explain why," senior investigator Dr. Nuri B. Farber, an associate professor of psychiatry, said in the news release.

If synthetic glucocorticoid drugs can be replaced with hormones made naturally in the body, it may be possible to avoid damage to brain cells while still promoting development of lungs in premature babies, the researchers said.

The study was expected to be presented Monday at the Society for Neuroscience annual meeting, in Washington, D.C.

In 2002, the American Academy of Pediatrics recommended a halt to post-natal glucocorticoid use unless used in clinical trials. However, it's still common practice to give the drugs to women at risk for preterm birth.

More information

The Nemours Foundation has more about premature babies.



-- Robert Preidt



SOURCE: Washington University School of Medicine in St. Louis, news release, Nov. 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. drugstore.com Offers Free Shipping to U.S. Troops Serving Overseas and in the United States
2. Kevin P. Miller's Film "Generation RX" Reveals Widespread Ethical Conflicts, Risks of Psychiatric Drugs to Children
3. Cancer drugs my build and not tear down blood vessels
4. drugstore.com inc. Reports Solid Revenue Growth and Record Gross Margins in the Third Quarter of 2008
5. When It Comes to Prescription Drugs, Get Smart
6. China Nepstar Chain Drugstore to Announce Third Quarter 2008 Financial Results on November 26
7. Medicaid policies vary widely for rheumatoid arthritis drugs
8. Tweens and Teens Double Use of Diabetes Drugs
9. Anti-VEGF drugs for retinal diseases could have serious side effects, scientists caution
10. Anti-VEGF Drugs for Retinal Diseases Could Have Serious Side Effects, Scientists Caution
11. Tweens and teens double use of diabetes drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drugs to Treat Lung Damage in Preemies May Harm Brain
(Date:7/21/2017)... ... July 21, 2017 , ... The Visiting ... the C. R. Bard Foundation, Inc. to support the music therapy ... service available through the nonprofit home care agency. Using evidence-based methods, professionally trained ...
(Date:7/21/2017)... ... July 21, 2017 , ... Sharon Kleyne is ... product of her research center at Bio-Logic Aqua Research® Water Life Science®, has ... greatest number of sufferers of blindness. “We think that Nature’s Tears® EyeMist® will ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... cruciate ligament (ACL) offer patients improved quality of life five years after injury, ... Medicine’s Annual Meeting in Toronto, Ontario, Canada. The study followed patients for ...
(Date:7/20/2017)... ... July 20, 2017 , ... ChenMed , a ... joined JenCare Senior Medical Center as Richmond Chief Medical Officer. Dr. ... Medicine, and Associate Chief Medical Officer of Ambulatory Services for the UVA Health System, ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... in Houston, is pleased to announce their expansion to the Midwest with the ... directors Alysse Hollis and Ronald Bell, and of counsels, John Peck and Robert ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... -- Did you know that PhRMA member companies invested $65.5 billion ... on brand medicines, generics and the supply chain account for 14 ... half of this (7 percent)? Or that the United ... capital investments in high-growth biopharmaceutical startups? ... The biopharmaceutical industry ...
(Date:7/15/2017)... 15, 2017 Enterin Inc., a Philadelphia ... disease (PD), today announced the completion of a $12.7 million ... Ventures III, as well as the participation of existing investors. ... to have the support of New Ventures III and our ... validation of the potential of our platform technology to transform ...
(Date:7/13/2017)... -- RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides ... San Jose for hi-tech, pharmaceutical and biomedical ... with its Fremont Innovation District, is excited to strategically partner ... to the hundreds of biotech, pharma and biomed companies throughout ...
Breaking Medicine Technology: