Navigation Links
Drugs to Treat Lung Damage in Preemies May Harm Brain
Date:11/17/2008

Even when given before birth, glucocorticoids tied to cognitive, motor control problems in mice

MONDAY, Nov. 17 (HealthDay News) -- Glucocorticoid drugs used to treat chronic lung damage in premature infants caused brain injury in mice and may cause cognitive and motor control problems even when they're given before birth, according to researchers at Washington University School of Medicine in St. Louis.

They examined the effects of the synthetic glucocorticoids dexamethasone and betamethasone, which are given to premature babies to aid lung development. The drugs caused brain cell death when given to mice four and 10 days after birth. The damage occurred in the cerebellum, the brain structure that controls movement and other functions.

"The cells that are damaged are called neural progenitor cells, which are responsible for producing new neurons. So you can imagine that if you kill the cells responsible for producing new neurons, you can cause severe neurodevelopmental effects," study first author Kevin K. Noguchi, a scientist in the department of psychiatry, said in a university news release.

That's what Noguchi and colleagues found when they examined adolescent mice that were given glucocorticoids during infancy. A single exposure to glucocorticoids permanently decreased the number of neurons in the cerebellum.

"The cerebellum connects to other brain structures, so when granule cells in the cerebellum are lost, you also have detrimental effects on cognitive function in non-motor regions of the brain. Other researchers have found IQ declines in children who have received these drugs early in life, and our findings may help explain why," senior investigator Dr. Nuri B. Farber, an associate professor of psychiatry, said in the news release.

If synthetic glucocorticoid drugs can be replaced with hormones made naturally in the body, it may be possible to avoid damage to brain cells while still promoting development of lungs in premature babies, the researchers said.

The study was expected to be presented Monday at the Society for Neuroscience annual meeting, in Washington, D.C.

In 2002, the American Academy of Pediatrics recommended a halt to post-natal glucocorticoid use unless used in clinical trials. However, it's still common practice to give the drugs to women at risk for preterm birth.

More information

The Nemours Foundation has more about premature babies.



-- Robert Preidt



SOURCE: Washington University School of Medicine in St. Louis, news release, Nov. 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. drugstore.com Offers Free Shipping to U.S. Troops Serving Overseas and in the United States
2. Kevin P. Miller's Film "Generation RX" Reveals Widespread Ethical Conflicts, Risks of Psychiatric Drugs to Children
3. Cancer drugs my build and not tear down blood vessels
4. drugstore.com inc. Reports Solid Revenue Growth and Record Gross Margins in the Third Quarter of 2008
5. When It Comes to Prescription Drugs, Get Smart
6. China Nepstar Chain Drugstore to Announce Third Quarter 2008 Financial Results on November 26
7. Medicaid policies vary widely for rheumatoid arthritis drugs
8. Tweens and Teens Double Use of Diabetes Drugs
9. Anti-VEGF drugs for retinal diseases could have serious side effects, scientists caution
10. Anti-VEGF Drugs for Retinal Diseases Could Have Serious Side Effects, Scientists Caution
11. Tweens and teens double use of diabetes drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drugs to Treat Lung Damage in Preemies May Harm Brain
(Date:3/23/2017)... & Seattle, WA (PRWEB) , ... March 23, 2017 , ... ... health emergency and now estimates that there could be four million Zika-related cases in ... epidemics to date with numbers of US cases reported per year skyrocketing to an ...
(Date:3/23/2017)... Virginia (PRWEB) , ... March 23, 2017 , ... ... public health services to their communities, 16 more public health departments have been ... week’s decisions bring another 4.5 million people into the expanding network of communities ...
(Date:3/23/2017)... MN (PRWEB) , ... March 23, 2017 , ... The ... internet and WiFi connectivity are making a huge impact on businesses and individual consumers ... Institute estimates the IoT will have a value anywhere from $4 trillion to $11 ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... families and businesses of the Norwalk and Vermillion areas, celebrates the newest ... (N.O.R.A.) is a nonprofit, community-based substance abuse prevention and peer recovery support ...
(Date:3/23/2017)... ... March 23, 2017 , ... The ... from the NCQA. The accreditation covers StayWell’s asthma, coronary artery disease, congestive heart ... granted to organizations that have excellent programs for the delivery and improvement of ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... INDIANAPOLIS , March 23, 2017 /PRNewswire/ ... and the William Sansum Diabetes Center have established a ... affected by diabetes through enhanced research, education and care. ... cardiovascular disease bears a disproportionate weight on Latino families ... David Kerr , M.D., FRCPE, director of Innovation ...
(Date:3/23/2017)... , March 23, 2017 ... and Healthcare disease pipeline guide Primary Hyperoxaluria - ... the Primary Hyperoxaluria (Genito Urinary System And Sex ... rare condition characterized by recurrent kidney and bladder ... substance called oxalate. Symptoms include blood in the ...
(Date:3/23/2017)... , March 23, 2017  Digital Pharmacist Inc. ... ), a rapidly growing digital health company, announced ... app that allows patients to manage their prescriptions. ... such as Denver Health Pharmacy, USave Pharmacy and ... helps Digital Pharmacist accelerate its product development schedule, ...
Breaking Medicine Technology: