Navigation Links
Drugs targeting blood vessels may be candidates for treating Alzheimer's
Date:3/7/2013

University of British Columbia researchers have successfully normalized the production of blood vessels in the brain of mice with Alzheimer's disease (AD) by immunizing them with amyloid beta, a protein widely associated with the disease.

While AD is typically characterized by a build-up of plaques in the brain, recent research by the UBC team showed a near doubling of blood vessels in the brain of mice and humans with AD.

The new study, published online last week in Scientific Reports, a Nature journal, shows a reduction of brain capillaries in mice immunized with amyloid beta a phenomenon subsequently corroborated by human clinical data as well as a reduction of plaque build-up.

"The discovery provides further evidence of the role that an overabundance of brain blood vessels plays in AD, as well as the potential efficacy of amyloid beta as basis for an AD vaccine," says lead investigator Wilfred Jefferies, a professor in UBC's Michael Smith Laboratories.

"Now that we know blood vessel growth is a factor in AD, if follows that drugs targeting blood vessels may be good candidates as an AD treatment."

AD accounts for two-thirds of all cases of dementia. The number of Canadians living with dementia is expected to reach 1.4 million by 2013, according to the Alzheimer's Society of Canada.

Jefferies is a researcher in UBC's Michael Smith Laboratories, the Brain Research Centre, and the Centre for Blood Research at UBC. He is also a member of a UBC's departments of Medical Genetics, Microbiology and Immunology, and Zoology. The study was done in collaboration with researchers at UBC's Biomedical Research Centre and Mount Sinai, School of Medicine in New York.


'/>"/>

Contact: Wilfred Jefferies
wilf@msl.ubc.ca
604-827-5167
University of British Columbia
Source:Eurekalert

Page: 1

Related medicine news :

1. Advance in re-engineering photosynthesis to make drugs, compounds or ingredients
2. Wide disparities in access to latest rheumatoid arthritis drugs across Europe
3. Newer Rheumatoid Arthritis Drugs Dont Seem to Increase Risk of Shingles
4. Drugs May Help Relieve Restless Legs Syndrome
5. Researchers show that lipid nanoparticles are ideal for delivering genes and drugs
6. Changing shape makes chemotherapy drugs better at targeting cancer cells
7. Newest Diabetes Drugs Linked to Higher Pancreatitis Risk
8. Report Calls for Better U.S. Efforts to Fight Counterfeit Drugs
9. Emerging cancer drugs may drive bone tumors
10. Countering fake and substandard drugs: IOM report releases Feb. 13
11. Dirty Drugs and We Know It: Attorneys at Console & Hollawell Comment on ISMP Survey Relating to Contaminated Drug Compounds and the Risks to Consumers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) ... Improvements Act of 1976, as amended ("HSR"), with respect ... Nasdaq: CPXX ) expired effective June 24, ... As previously announced on May 31, 2016, Jazz Pharmaceuticals ... which Jazz Pharmaceuticals has commenced a tender offer for ...
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology: