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Drugs in the pipeline: new therapies that could change treatment strategies
Date:4/15/2008

r immune cells that carry a mutation in the receptor protein Fc?RIIIa 158-F do not have the same response, Forero says. This is an issue that is related to the patients own biological makeup, not to the cancer cells themselves, he adds. There are three different classes of Fc? receptors to which the monoclonal antibody binds on leukocyte effector cells T helper cells -- that direct other immune cells to the antigen. Response to rituximab depends on variants in the receptors these helper cells use.

AME-133v is an anti-CD20 antibody engineered to bind more strongly to these variant receptors. In preclinical studies, it demonstrated a 10-fold improved killing power of human B cells, compared with rituximab, researchers report.

Of the 22 patients treated with AME-133v in this study, 20 had been treated with rituximab and 18 also had chemotherapy. All were Fc?RIIIa 158-F carriers. This was a dose escalation study, and researchers report that the agent was well tolerated at all doses 90 percent of patients experienced only grade I adverse events.

AME-133v appears to be capable of binding with high specificity to cell-surface antigens, resulting in targeted killing of malignant cells, relative sparing of normal tissues, and low toxicity, Forero said.

Promising clinical activity of an NAB paclitaxel plus gemcitabine combination in a disease-specific phase I trial in patients with advanced pancreatic cancer: Abstract 4179

Late-breaking data will be presented at the meeting.

Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatment: Abstract 1210

Researchers from the Sanford School of Medicine at The University of South Dakota have demonstrated that mifepristone prevents regrowth of ovarian cancer cells that survive standard chemotherapy.

Utilizing a cell culture system, our work provides evidence that giving mifepris
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Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

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