Navigation Links
Drugs in the pipeline: new therapies that could change treatment strategies
Date:4/15/2008

SAN DIEGO New drug compounds, and old ones put to new use, offer doctors and patients new hope for treating and preventing cancer. Studies presented at the 2008 Annual Meeting of the American Association for Cancer Research, April 12-16, show promise and progress against brain, colorectal, rectal and ovarian cancers and lymphoma.


A Multidisciplinary Phase II Study of AZD2171 (cediranib), an Oral Pan-VEGF Receptor Tyrosine Kinase Inhibitor, in Patients with Recurrent Glioblastoma: Abstract LB-247

The investigational drug AZD2171 (cediranib) may help shrink tumors and prolong survival of patients with a relatively common, aggressive type of brain cancer, according to results from a clinical trial conducted by Boston researchers.

In a phase II study of 31 patients with recurrent glioblastoma, researchers observed that daily treatment with cediranib decreased tumor volume by more than half in 56 percent of patients.

Nearly 26 percent of patients were alive and their cancer had not progressed six months into treatment. On average, patients experienced a progression-free survival of 117 days and overall survival of 221 days. In addition, cediranib was found to alleviate brain swelling a major cause of morbidity among these patients.

Cediranib is a selective signaling inhibitor for vascular endothelial growth factor (VEGF), which promotes formation of new blood vessels that tumors need for nourishment and growth. The drug targets all three receptors for VEGF, one of which is expressed on the endothelial cells in glioblastoma.

These are promising, early results but are from a single study of 31 patients, so ongoing larger studies will be critical to determine if the findings are corroborated, said lead author Tracy Batchelor, M.D., M.P.H., executive director of the Stephen E. and Catherine Pappas Center for Neuro-Oncology at the Massachusetts General Hospital Cancer Center. One important
'/>"/>

Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. New review suggests caution on drugs to raise good cholesterol
2. Can cancer drugs combine forces?
3. Study provides hope that some transplant patients could live free of antirejection drugs
4. Study provides hope that some transplant patients could live free of anti-rejection drugs
5. RA Drugs Linked to Slight Skin Cancer Risk
6. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
10. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
11. 2 drugs equally effective for heart patients undergoing angioplasty, Mayo study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 30, 2014 In today’s world, a good ... get. Snoring and sleep apnea (a medical problem where the ... their bed partners of the rest they need to face ... population snores and 20 million people in the United States ... diagnosed and treated; and of those treated, many cannot tolerate ...
(Date:8/30/2014)... 30, 2014 Market Research Report ... is a professional and in-depth market survey on ... firstly reviews the basic information of Lab Oven ... report then explores global and China’s top manufacturers ... production value, and market share etc. , The ...
(Date:8/30/2014)... New York (PRWEB) August 30, 2014 ... for transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ) filed ... request to sever four cases selected for one ... Order issued on August 18, 2014, U.S. District ... of West Virginia disagrees with Boston Scientific’s contention ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 In today’s ... and increasingly difficult to get. Snoring and sleep apnea ... and breathing stops) robs people and their bed partners ... challenges. Up to 45% of the population snores and ... sleep apnea. Of these, only 10% have been diagnosed ...
(Date:8/30/2014)... Delhi, India (PRWEB) August 30, 2014 ... online reputation management industry, has announced to offer guarantee ... has decided to offer this guarantee because of its ... more than 200 clients from all over the world ... doing extremely good job. , On being asked ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Removecomplaints.net Announces Guaranteed Complaints Removal Services 2
... in two men and one in three women, cancer remains ... This year, in the nation,s capital, the American Association for ... draw more than 17,000 academics, scientists, clinicians, industry leaders, survivors ... findings in this fast-moving arena. To help you ...
... Remedi ... Ohio long-term care marketplace. , ... Baltimore, Md. (PRWEB) February 4, 2010 -- Remedi SeniorCare has expanded its ... new customers for its comprehensive pharmacy services., , ,Vista Grande Villa of Jackson, Michigan, ...
... 50 ... “text to” donation number on February 6th to heighten awareness about the Haitian crisis ... ... nonprofit dedicated to providing health care services to underprivileged children in resource limited countries, ...
... to preventive treatment, researchers say , THURSDAY, Feb. 4 ... in mothers and fetuses that appear to boost the ... traits are found in genes that regulate inflammation -- ... material that holds cells within tissues. , "A ...
... ... a perfect one of a kind Valentines gift. , ... Naperville, IL (PRWEB) February 4, 2010 -- The concept of ... couples to spend wonderful time away from distractions while enjoying fellowship with other couples and ...
... , As Lower-Cost Methadone Prescribing Increases, ... Feb. 4 In a unique and ... -- 2009, the deaths involving methadone were found to be ... opioid prescriptions but is responsible for a third of the ...
Cached Medicine News:Health News:Two Long-Term Care Organizations Select Remedi SeniorCare for Pharmacy Services 2Health News:Two Long-Term Care Organizations Select Remedi SeniorCare for Pharmacy Services 3Health News:One5 Foundation Launches National Haitian Relief Campaign with TShirtAds 2Health News:One5 Foundation Launches National Haitian Relief Campaign with TShirtAds 3Health News:The Love Convention Returns With "Something New" at Hotel Arista on Valentines Weekend 2Health News:The Love Convention Returns With "Something New" at Hotel Arista on Valentines Weekend 3Health News:Methadone and Other Opioids Not Always Equivalent, Conversion Can Be Lethal 2Health News:Methadone and Other Opioids Not Always Equivalent, Conversion Can Be Lethal 3Health News:Methadone and Other Opioids Not Always Equivalent, Conversion Can Be Lethal 4
(Date:8/30/2014)... ANDOVER, Mass. , Aug. 30, 2014   ... launch of Affiniti, a new ultrasound system ... overcome the demands of increasing patient volumes and cost ... Cardiology (ESC) Congress 2014 in Barcelona ... radiology/ultrasound departments facing more patients with fewer resources deliver ...
(Date:8/29/2014)... DALLAS , Aug. 29, 2014 /PRNewswire-iReach/ -- ... Crystallography Scanner Industry, 2009-2019 is a professional and ... X-Ray Crystallography Scanner industry . The report firstly ... including its classification, application and manufacturing technology. The ... of X-Ray Crystallography Scanner listing their product specification, ...
(Date:8/29/2014)... ANGELES , Aug. 29, 2014  Chuma ... both financing alternatives and turnkey support services for ... announce that FINRA processed and approved the Company,s ... 29, 2014, CannaMed Corporation will be known as ... change was accomplished through a merger with the ...
Breaking Medicine Technology:Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 2Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 3Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 2X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 3X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 5CannaMed Announces Name Change and Trading Symbol Change 2CannaMed Announces Name Change and Trading Symbol Change 3
... 16, 2011  Kensey Nash Corporation (NASDAQ: KNSY ) ... to enter into non-binding mediation in an attempt to resolve ... Angio-Seal vascular closure device, as well as other related claims. ... are currently to be paid, and should since 2007 have ...
...  Pharmasset, Inc. (Nasdaq: VRUS ) announced today ... QUANTUM Phase 2b trial of the guanine nucleotide analog ... containing PSI-938. There are 235 individuals with hepatitis C ... with PSI-938 alone or in combination with PSI-7977 or ...
Cached Medicine Technology:Kensey Nash to Enter Into Mediation with St. Jude Medical over Angio-Seal Contract Disputes 2Kensey Nash to Enter Into Mediation with St. Jude Medical over Angio-Seal Contract Disputes 3Kensey Nash to Enter Into Mediation with St. Jude Medical over Angio-Seal Contract Disputes 4Pharmasset Announces Intent to Amend QUANTUM Trial 2Pharmasset Announces Intent to Amend QUANTUM Trial 3
Console Horizontal Airflow Cabinet...
... Ideal for biocompatibility testing at various ... of air through a clean heating ... temperature up to 140F. Transparent panels ... shields allow easy access to the ...
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
This modular benchtop fume hood ventilates and purifies chemical fumes, allowing safe indoor release of exhaust. Bonded charcoal filters remove most organic contaminants. Options include final HEPA f...
Medicine Products: