Navigation Links
Drugs for Irritable Bowel Might Increase Cancer Risk
Date:10/19/2009

Long-term use of thiopurines bears further study, researchers say

MONDAY, Oct. 19 (HealthDay News) -- The use of thiopurine drugs to treat inflammatory bowel disease (IBD) increases the risk of cancers related to viral infection, according to a new study.

IBD includes Crohn's disease and ulcerative colitis. Thiopurine drugs are used to suppress the immune system in order to maintain remission in IBD patients.

For this study, French researchers analyzed data on 19,486 IBD patients (60 percent with Crohn's and 40 percent with ulcerative colitis or unclassified IBD) who were followed for a median of 35 months.

At the start of the study, 30 percent of patients were taking thiopurines, 14 percent had discontinued them, and 56 percent had never received thiopurines. During the study, 23 patients developed malignant lymphoproliferative disorders (LD) -- cancers that are associated with viral infection, particularly those linked to Epstein Barr virus (EBV) infection.

Of the 23 patients with LD, 22 had non-Hodgkin's lymphoma and one had Hodgkin's lymphoma. Incidence rates of LD were 0.90 per 1,000 patient-years in those receiving thiopurines, 0.20 per 1,000 patient-years in those who'd discontinued the drugs, and 0.26 per 1,000 patient-years in those who'd never taken thiopurines.

The researchers calculated that IBD patients taking thiopurines had a more-than-five-fold increased risk compared to those who'd never received the drugs. Older patients, men, and those who'd had IBD for longer were also at increased risk of LD.

"Extrapolating our results, the absolute cumulative risk of (LD) in young patients receiving a 10-year course of thiopurines remains low (less than 1 percent) and does not undermine the positive risk-benefit ratio of these drugs. For elderly patients and unlimited treatment periods, the question should be addressed in dedicated studies," wrote Laurent Beaugerie, a professor at
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Pitt researchers find candidates for new HIV drugs
2. Designing drugs and their antidotes together improves patient care
3. Risk of abnormally slow heart rate twice as high in those taking drugs to slow Alzheimers
4. Teen attitudes toward smoking linked to likelihood of drinking and using drugs
5. UCLA study identifies 2 chemicals that could lead to new drugs for genetic disorders
6. GENova Biotherapeutics secures new cancer drugs targets
7. Reportlinker Adds World Anti-Obesity Drugs Market Report
8. Yeast unravels effects of chemotherapy drugs
9. Vitro's Cancer Stem Cell Therapy Complements New Hedge Hog Drugs
10. Antiviral Drugs Should Be Used Cautiously to Fight Flu, U.S. Says
11. Reportlinker Adds Prescription Drugs Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... , ... September 02, 2015 , ... Ericson is a ... Education Director for HCPro and Associate Director of Education for the Association for Clinical ... CDI and ICD-10 for CDI Boot Camps. She serves as a CDI subject matter ...
(Date:9/2/2015)... ... ... Every year at this time, students prepare to go back to school. ... the academic workload confronting them. They just don’t have the skills needed to do ... students how to study. , “Bankers bank. Salesmen sell. Teachers teach. The job of ...
(Date:9/2/2015)... City, KS (PRWEB) , ... September 02, 2015 , ... ... opened its newest office in Kansas – its Johnson County location. Amada ... in healthcare. Mike has a registered nurse background and spent over 20 years in ...
(Date:9/2/2015)... North Las Vegas, NV (PRWEB) , ... September ... ... in Las Vegas and Fort Lauderdale, CENTURION SERVICE GROUP is internationally known as ... the largest medical auction house in the world, selling more than 100,000 pieces ...
(Date:9/2/2015)... ... 02, 2015 , ... On September 9, 2015, over 27,000 people from all ... single-company convention to date for the state of Utah. , “We are thrilled with ... states David Stirling, doTERRA CEO. “One of the most exciting elements of our convention ...
Breaking Medicine News(10 mins):Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 2Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 3Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 4Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 2Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 3Health News:Amada Senior Care Expands to Greater Kansas City 2Health News:Over 1800 Lots of Surplus Used Medical Equipment 2Health News:Over 1800 Lots of Surplus Used Medical Equipment 3Health News:doTERRA to Host the Largest Single-Company Convention in the State of Utah 2
... Dec. 1 The Kerlan Jobe Orthopaedic Clinic, a sports ... United States $3 million to settle allegations that it received ... , The settlement resolves allegations ... of stock option grants, donations to the Kerlan Jobe Foundation, ...
... A scientist who broadened the understanding of how we experience ... -- has won the 2010 University of Louisville Grawemeyer Award ... University in Montreal, was selected for the award from among ... of injury but instead in their brain through a pathway ...
... more likely, British study finds , TUESDAY, Dec. 1 (HealthDay ... to deliver a very preterm baby than more affluent women, ... British study shows. , The University of Leicester research team ... the association between economic status and preterm birth. , For ...
... on computed tomography (CT) imaging of changes in tumors ... bevacizumab may have the potential to predict overall survival, ... of JAMA . The addition of ... with improved survival in patients with stage IV colorectal ...
... ... ... largest national HIV non-profit organizations, is changing its name to HealthHIV and launching a new ... promote the organization’s new vision and expanded capabilities and reach. , , , , ,“HealthHIV ...
... With employee benefit choices becoming more complex, a growing ... during open enrollment season, according to a new survey by ... employers who offer these tools believe they lead employees to ... survey, 45 percent of companies offered employees self-service decision tools ...
Cached Medicine News:Health News:Los Angeles' Kerlan Jobe Orthopaedic Clinic Pays $3 Million to Settle Kickback Allegations 2Health News:Scientist Who Helps Explain Pain Wins Grawemeyer Award 2Health News:More Preemies Born Among the Poor 2Health News:Criteria based on CT imaging after chemotherapy may help predict survival 2Health News:National HIV Non-Profit Announces New Name 2Health News:Employers Plan to Increase Use of Self-Service Decision-Making Technology For Open Enrollment, Watson Wyatt Survey Finds 2Health News:Employers Plan to Increase Use of Self-Service Decision-Making Technology For Open Enrollment, Watson Wyatt Survey Finds 3
(Date:9/2/2015)... 2, 2015  MGC Diagnostics Corporation (NasdaqCM: MGCD), a ... to discuss its financial results for the third quarter ... will be at 4:30 p.m. ET on Thursday, September ... the third quarter of fiscal 2015 after the markets ... Participants can dial (877) 317-6789 or (412) 317-6789 to ...
(Date:9/2/2015)... Ill. , Sept. 2, 2015 Tumultuous ... a frenzy of health care M&A activity – have ... moderate-to-severe access restrictions on pharmaceutical sales reps. This marks ... limit access has crossed the halfway point, according to ... sales and marketing firm ZS . ...
(Date:9/2/2015)... , Sept. 2, 2015 On ... broad spectrum of physicians who prescribe biologics ... of Clinical Endocrinologists, American College of Rheumatology, ... Organizations, and North American Society for Pediatric ... letter to Centers for Medicare and Medicaid ...
Breaking Medicine Technology:MGC Diagnostics Corporation to Report Third Quarter Fiscal 2015 Financial Results on Thursday, September 10, 2015 2Crossing the threshold: More than half of physicians restrict access to sales reps 2Crossing the threshold: More than half of physicians restrict access to sales reps 3Crossing the threshold: More than half of physicians restrict access to sales reps 4Crossing the threshold: More than half of physicians restrict access to sales reps 5Physician Groups Urge CMS: Follow FDA Lead on Unique Names for Biological Medicines 2Physician Groups Urge CMS: Follow FDA Lead on Unique Names for Biological Medicines 3Physician Groups Urge CMS: Follow FDA Lead on Unique Names for Biological Medicines 4Physician Groups Urge CMS: Follow FDA Lead on Unique Names for Biological Medicines 5Physician Groups Urge CMS: Follow FDA Lead on Unique Names for Biological Medicines 6
... Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX ), ... and gastroenterology markets, today announced that Rick S. Greene, ... appointed interim Vice President, Finance & Accounting effective April ... of experience in financial management and reporting.  He previously ...
... 4, 2011 PLC Systems Inc. (OTCBB: PLCSF), ... announced that final results from the REMEDIAL II ... presented today. The results showed that RenalGuard was ... care at preventing Contrast-Induced Nephropathy (CIN) and Dialysis ...
Cached Medicine Technology:Cumberland Pharmaceuticals Appoints Rick S. Greene as Vice President, Finance & Accounting 2Cumberland Pharmaceuticals Appoints Rick S. Greene as Vice President, Finance & Accounting 3REMEDIAL II Trial of PLC's RenalGuard® Demonstrates Greater Efficacy than Current Standard of Care 2REMEDIAL II Trial of PLC's RenalGuard® Demonstrates Greater Efficacy than Current Standard of Care 3REMEDIAL II Trial of PLC's RenalGuard® Demonstrates Greater Efficacy than Current Standard of Care 4
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
Medicine Products: