Navigation Links
Drug's effect on Alzheimer's may depend on severity of disease
Date:7/16/2014

A cancer drug that has shown promise against Alzheimer's disease in mice and has begun early clinical trials has yielded perplexing results in a novel mouse model of AD that mimics the genetics and pathology of the human disease more closely than any other animal model.

The drug, bexarotene, was found to reduce levels of the neurotoxic protein amyloid-beta in experimental mice with late-stage Alzheimer's but to increase levels during early stages of disease.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease. That experimental mouse carries a human gene that confers on people a 15-fold elevated risk of developing AD, making it the most important known genetic risk factor for the disease.

Alzheimer's disease is the most common form of dementia, affecting more than five million Americans. The disease is progressive and eventually fatal. One of the hallmarks of AD is the appearance of dense plaques in the brain composed of clumps of amyloid-beta. But recent research indicates that smaller, soluble forms of amyloid-beta -- rather than the solid plaques -- are responsible for the death of nerve cells that leads to cognitive decline.

Humans carry a gene for a protein in cells called apolipoprotein E, which helps clear amyloid-beta from the brain by binding to it and breaking it down. LaDu's mice carry the most unfortunate variant in humans, called APOE4, or APOE3, which is neutral for AD risk.

"APOE4 is the greatest genetic risk factor for Alzheimer's disease," said LaDu, who is professor of anatomy and cell biology at UIC. "Our previous work showed that compared to APOE3, the apolipoprotein produced by the APOE4 gene does not bind well to amyloid-beta and so does not clear the neurotoxin from th
'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New assay to spot fake malaria drugs could save thousands of lives
2. The Lancet: New trial suggests cheaper drugs for common heart attack procedure could improve outcomes and save health budgets millions
3. Some aggressive cancers may respond to anti-inflammatory drugs
4. Delivering drugs on cue
5. Among weight loss methods, surgery and drugs achieve highest patient satisfaction
6. Emerging HIV epidemics among people who inject drugs in the Middle East and North Africa
7. Dismisses link between suicidal behaviour and ADHD drugs
8. Chemical strategy hints at better drugs for osteoporosis, diabetes
9. Effective drugs for Parkinsons reduce symptoms of Rett syndrome in mice
10. Mayo Clinic moves small-molecule drugs through blood-brain barrier
11. CDC report: Patients harmed after health-care providers steal patients drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Many mainstream media outlets have run stories ... how much of that news reporting is true? Many ... measles, but whose youngsters later developed autism, will assemble ... comprised of professionals, clinicians, researchers, therapists, advocates, and others. ... questions about the body and childhood health will have ...
(Date:3/2/2015)... March 02, 2015 Éminence Organic Skin ... care, is excited to announce the launch of the ... an effective, time-saving solution for those with combination skin. ... in 1 divided jar to separate the products, consists ... Treatment. The Balancing Moisturizer Duo, also in a divided ...
(Date:3/2/2015)... Minnesota (PRWEB) March 02, 2015 ... new strategic relationship with First Protective Insurance Group ... initiative will allow First Protective affiliated advisors to ... implementation support that Secura Consultants delivers. ... a national leader in the design and implementation ...
(Date:3/1/2015)... (PRWEB) March 02, 2015 Security ... the ancillary benefits market, announced the addition of ... PrimeStar Individual Vision Insurance launched today, complete with ... plan will utilize the VSP® Vision Care network ... the private practice space. The PrimeStar Select Vision ...
(Date:3/1/2015)... 01, 2015 Women’s Excellence is pleased ... terms on their website. There are over 75 terms ... time. , “This gives our patients a better understanding ... terminology that they may not understand. With this resource, our ... mobile optimized) and find terms and phrases that they may not ...
Breaking Medicine News(10 mins):Health News:Growing List of Professionals Gather for World’s Most Comprehensive Autism Conference in Chicago, May 2015 2Health News:Éminence Organic Skin Care Launches Innovative Collection for Combination Skin 2Health News:Éminence Organic Skin Care Launches Innovative Collection for Combination Skin 3Health News:Secura Consultants and First Protective Insurance Group Announce Strategic Relationship 2Health News:Security Life Insurance Company Launches Individual Vision Insurance Product 2
... ... Dec. 21 Jamie Oliver, celebrity chef and standard-bearer in the fight against ... the 2010 TED Prize, an award granting recipients $100,000 and something much bigger ... The host of 12 television series seen in 130 countries and bestselling author ...
... 21 The Small Business & Entrepreneurship Council (SBE Council) ... continues to ignore the plight of U.S. small businesses, and ... drive business costs higher. , "Rather than moving in a ... health bill imposes an even higher tax burden on our ...
... Arteries appear to be less clogged in those who nurse ... Although many women choose to breast-feed because of the numerous ... breast-feeding may also help the health of the mothers, hearts ... 300 women, researchers found that those who had not breast-fed ...
... ... Children’s Hospitals (N.A.C.H.) expressed support for children’s health care provisions ... The bill extends the Children’s Health Insurance Program (CHIP) by two ... not go far enough in reducing cuts to supplemental Medicaid payments ...
... , , , ST. LOUIS, Dec. ... a new service for healthcare systems needing to hire at ... "We will help these new clients by setting up and ... long-term needs," says Charlie Holland, President of PracticeMatch Services. ...
... , GREAT RIVER, N.Y., Dec. 21 ... enterprise-wide software and services for health and human ... clinical software solution for the Monterey County (Calif.) ... in conjunction with Division staff, makes Monterey one ...
Cached Medicine News:Health News:Jamie Oliver, Chef and International Nutrition Advocate, Named Recipient of 2010 TED Prize 2Health News:Jamie Oliver, Chef and International Nutrition Advocate, Named Recipient of 2010 TED Prize 3Health News:Jamie Oliver, Chef and International Nutrition Advocate, Named Recipient of 2010 TED Prize 4Health News:Jamie Oliver, Chef and International Nutrition Advocate, Named Recipient of 2010 TED Prize 5Health News:Jamie Oliver, Chef and International Nutrition Advocate, Named Recipient of 2010 TED Prize 6Health News:Senate Health Bill Remains a High-Cost Minefield for Small Business 2Health News:Breast-Feeding May Protect a Woman's Heart 2Health News:Breast-Feeding May Protect a Woman's Heart 3Health News:Senate Health Care Package Is a Step in Right Direction, Does Not Go Far Enough on Access 2Health News:Senate Health Care Package Is a Step in Right Direction, Does Not Go Far Enough on Access 3Health News:PracticeMatch Announces New Service 2Health News:Netsmart Technologies Implements Electronic Medical Record Solution for Monterey County Behavioral Health Services on Fast Track and Under Budget 2Health News:Netsmart Technologies Implements Electronic Medical Record Solution for Monterey County Behavioral Health Services on Fast Track and Under Budget 3
(Date:3/2/2015)... 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE MKT: IMUC) today ... ended December 31, 2014 on March 9, 2015. The Company also ... Thursday, March 12, 2015, at 5:00 pm ET. The call will ...   , , , LIVE CALL:  , ... 92238648. , , , , ...
(Date:3/1/2015)... , March 1, 2015 /CNW Telbec/ -   Ergoresearch Ltd ... and known under the « Équilibre, ... the second quarter Ended on December 31, 2014. All ... currency. Revenues for the second quarter ... 2014 totaled $ 4 095 112 decreasing by 8,8 % compared to ...
(Date:3/1/2015)...  USPlabs has notified the Food and Drug ... media reports saying that a company product contains ... 28, 2015, the Center for Drug Evaluation and ... contamination of a dietary supplement product labeled as ... "OEP") with a prescription drug active ingredient, fluoxetine. ...
Breaking Medicine Technology:ImmunoCellular Therapeutics to Report 2014 Financial Results on March 9, 2015; a Business Update Conference Call and Webcast is Scheduled for March 12, 2015 2Second Quarter results - Fiscal 2015 - Ergoresearch reports its results for the quarter ended December 31, 2014. 2Second Quarter results - Fiscal 2015 - Ergoresearch reports its results for the quarter ended December 31, 2014. 3Second Quarter results - Fiscal 2015 - Ergoresearch reports its results for the quarter ended December 31, 2014. 4OEP Product Is Counterfeit 2
... TEL-AVIV, Israel , March 15, 2010 Cheetah Medical, a,worldwide leader in noninvasive hemodynamic and cardiac output ... and also included Robert,Bosch Venture Capital (RBVC), MVM Life Science Partners (MVM) and existing,investors. , ... ... ...
... With heart disease continuing to be the No. 1 cause of death in the U.S., Atherotech Inc. has ... company is expanding its disease management services with the goal of helping physicians reduce death and disability from heart disease. ... ... , ...
Cached Medicine Technology:Cheetah Medical Closes $20 Million Series B Financing 2Cheetah Medical Closes $20 Million Series B Financing 3Cheetah Medical Closes $20 Million Series B Financing 4Cheetah Medical Closes $20 Million Series B Financing 5Cheetah Medical Closes $20 Million Series B Financing 6Atherotech Recruits Top Experts in Fight Against Heart Disease 2Atherotech Recruits Top Experts in Fight Against Heart Disease 3Atherotech Recruits Top Experts in Fight Against Heart Disease 4Atherotech Recruits Top Experts in Fight Against Heart Disease 5Atherotech Recruits Top Experts in Fight Against Heart Disease 6
For injecting viscoelastic to all meridians of the anterior chamber and to coat intraocular lenses. 20G x 7.8in (.90 x 22mm)....
For administering anesthetic agents into the posterior sub-Tenon's space 20G x 1in (.90 x 25mm)...
... most versatile diagnostic tool in the eye ... glaucoma, diabetic retinopathy, age-related macular degeneration and ... the only system in the market that ... the optic nerve areas in one session, ...
Stryker Leibinger offers a variety of different Titanium Implant Systems and special instrument sets, which enable our customers to treat a wide range of indication...
Medicine Products: