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Drugs are safe, active in patients normally ineligible for clinical trial
Date:12/10/2010

as noted in two patients - one with metastatic sarcoma and one with breast cancer.

Benchmarks of survival and response that would require stopping the trial have not been met and Garcia-Manero said indications are that the study will continue and not hit either measure.

"This combination is safe and active for these poor-prognosis patients at similar levels of safety and activity seen among patients who are eligible for clinical trials," Garcia-Manero said.

Garcia-Manero and colleagues also have developed a prognostic model for MDS patients that takes into account additional diseases or conditions, called co-morbidities, to help predict survival in those patients.

Azacitidine, known commercially as Vidaza, activates genes that have been silenced by stripping them of methyl groups, which protrude like bookmarks from a gene's promoter region. Vorinostat, known commercially as Zolzinza, activates genes by protecting acetyl groups that adhere to histones - proteins connected to DNA like beads on a string.

Both drugs reactivate enough tumor-suppressing genes to have an effect on AML and MDS.


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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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