Navigation Links
Drugs against winter vomiting disease one step closer
Date:6/10/2009

The virus that causes winter vomiting disease invades cells by attaching to particular sugar molecules on the surface of the cells. This is the conclusion of a thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden. This result may be an important step in the development of a drug against the regular hospital-based epidemics caused by the virus.

Winter vomiting disease is an infectious inflammation of the gastro-intestinal tract, which occurs principally during the winter months. There is presently no vaccine, and no drugs to combat the infection. The disease causes diarrhoea and vomiting, and its consequences may be very serious for people who are already seriously ill or weak.

"We are aiming to develop a drug that can be given to vulnerable persons and to children in day-care when it has become clear that another epidemic is starting to break out. More research will, however, be required. Our results are important steps along the way, but it will probably be several years before a drug is commercially available", says Gustaf Rydell who successfully defended his PhD thesis on June 8, 2009.

The thesis describes how the virus for winter vomiting disease can attach to cells by binding to special sugar chains. One of these chains is characterised in that it has a monosaccharide known as sialic acid at its end. The thesis also shows that the virus binds to such sugar chains even when they are not part of the cell surface. This means that it may be possible for the sugar chains to prevent the virus infecting the cells by blocking its binding structures.

"Our results suggest that the sugar chains that have sialic acid are important for infection by the virus, but this must be confirmed. If it is true, it would be possible to develop a drug that blocks the access of the virus to the sugar molecule. One thing that we must investigate first, however, is whether there are other target molecules that the virus can use to enter the cell. These may be the starting point for even more effective drugs", says Gustaf Rydell.


'/>"/>

Contact: Elin Lindstrm Claessen
elin.lindstrom@sahlgrenska.gu.se
46-317-863-869
University of Gothenburg
Source:Eurekalert  

Related medicine news :

1. New review suggests caution on drugs to raise good cholesterol
2. Can cancer drugs combine forces?
3. Study provides hope that some transplant patients could live free of antirejection drugs
4. Study provides hope that some transplant patients could live free of anti-rejection drugs
5. RA Drugs Linked to Slight Skin Cancer Risk
6. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
10. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
11. 2 drugs equally effective for heart patients undergoing angioplasty, Mayo study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drugs against winter vomiting disease one step closer
(Date:9/22/2017)... , ... September 22, 2017 , ... ... Rob Lowe, explores the world of Alzheimer’s. Alzheimer’s is a disease estimated to ... This according to information published by the Alzheimer’s Association, a leading voice in ...
(Date:9/22/2017)... Encino, CA (PRWEB) , ... September 22, 2017 ... ... ways to preserve fertility and create life. Although frozen embryos have a slight ... circumstances. , “Egg freezing is a wonderful opportunity for women undergoing medical ...
(Date:9/21/2017)... ... ... SABRE is raising awareness about personal safety with a Chicago Transit Authority ad ... Chicago, Illinois, based self-defense brand has been waiting for an opportunity like this to ... personal safety into their own hands. , The ads focus on their diverse line ...
(Date:9/21/2017)... ... September 21, 2017 , ... Bill Howe Plumbing’s mission is ... and give back to the community. For over 37 years, they have operated with ... serving plumbing in San Diego. They were chosen as the Best San ...
(Date:9/21/2017)... New York (PRWEB) , ... September 21, 2017 , ... ... named “One Yoga Mat Revolution” on 6th, 7th and 8th October at Miranda Kuo ... renowned yoga mat art pieces, such as Zen Kodo mat. Wanderlust , one ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017  Zimmer Biomet Holdings, Inc. ... healthcare, today announced that it will be participating in ... Conference at the Grand Hyatt hotel in New York.  ... at 11:40 a.m. Eastern Time. A live ... Biomet,s Investor Relations website at http://investor.zimmerbiomet.com .   ...
(Date:9/6/2017)... WILMINGTON, Del. , Sept. 6, 2017 NeuroRx, ... for Acute Suicidal Ideation and Behavior (ASIB), has been granted ... for its sequential therapy of NRX-100 (ketamine HCl) followed by ... patients in a pivotal trial of this sequential therapy targeting ... bipolar depression. 1 ...
(Date:9/5/2017)...  Just 18 months after its February 2016 launch, ... the appointment of three new senior people to its ... Jones-Phillips and James Wright bring decades ... Tammy Wynne joins as Director, ... She has over ten years, experience in global market ...
Breaking Medicine Technology: