Navigation Links
Drugs That Shift Cell's Energy Find New Purpose
Date:2/15/2010

Researchers eye them as new treatments for heart disease, other conditions

MONDAY, Feb. 15 (HealthDay News) -- Researchers have identified several drugs that can change the way cells convert nutrients into energy, and they could potentially be used to treat heart attack, stroke and other conditions.

"Shifts in cells' energy production pathways take place naturally during development and in response to demanding activities -- like sprinting versus long-distance running. They are also known to be involved in several disease states," study leader Dr. Vamsi Mootha, of the Center for Human Genetic Research at Massachusetts General Hospital, said in a news release from the hospital.

"We wanted to identify compounds that can safely induce this shift -- those that have previously been discovered are too toxic -- and investigate their therapeutic potential in animal models," Mootha said.

Mootha and colleagues screened almost 3,700 compounds and pinpointed several U.S. Food and Drug Administration-approved drugs -- including an over-the-counter anti-nausea drug -- that can shift cellular energy.

The study was published Feb. 14 online in the journal Nature Biotechnology.

The findings may eventually lead to new treatments for some serious health problems, but much more research is needed, the researchers noted.

"Before we can think about human studies, we need to do rigorous animal testing to determine optimal, safe dosing regimens and learn more about how [these] drugs work," said Mootha, an assistant professor of systems biology at Harvard Medical School.

More information

The American Heart Association outlines heart attack treatments.



-- Robert Preidt



SOURCE: Massachusetts General Hospital, news release, Feb. 14, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Diabetes Drugs Avandia, Actos Tied to Fractures in Women
2. Adapting to clogged airways makes common pathogen resist powerful drugs
3. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
4. The private sale of drugs in public hospitals
5. Glaucoma Drugs May Play Role in Longer Life
6. Rehabilitation for Opiate Addiction Without Maintenance Drugs
7. Review and approval of oncology and hematology drugs at FDA from 2005 to 2007
8. Fake Drugs Bought on the Web Pose Big Health Risks
9. Scientists show how molecular switch helps pancreatic cancer beat drugs
10. Common antidepressant drugs linked to lactation difficulties in moms
11. Counterfeit Internet drugs pose significant risks and discourage vital health checks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 2017 , ... The law firm of Enea, Scanlan & Sirignano, LLP, ... resident Lauren C. Enea has joined the firm as an associate attorney. Ms. Enea, ... in elder law, Medicaid planning and applications, and Wills, Trusts and Estates. Samantha ...
(Date:3/24/2017)... ... March 24, 2017 , ... Empower ... upgrading their training and leads programs. , In February, 2017, Empower Brokerage introduced ... agents, Performance Partners is designed to teach how to maximize their sales efforts, ...
(Date:3/24/2017)... ... March 24, 2017 , ... “End Time GPS”: a dauntless and enlightened ... “End Time GPS” is the creation of published author, Wesley Gerboth, a World War ... munitions and space-vehicle projects. Now, at age ninety-one, he shares the Wisdom God bestowed ...
(Date:3/24/2017)... ... ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a boisterous story ... fullest, as God intended. “The Adventures of Joey, The Dog Who Barks at Puddles” ... passion for writing, especially about truth and human behavior. , Published by Christian Faith ...
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the ... located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the ... living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017  A new genetic test has ... of individuals who carry HLA-B*15:02 and ... yet potentially deadly side effect of certain medications ... gene HLA-B*15:02 is strongly associated with ... syndrome and toxic epidermal necrolysis in patients treated ...
(Date:3/23/2017)... Prima BioMed has presented encouraging early signs ... combination with Keytruda, with one of the six melanoma ... response. Recruitment in the second cohort is complete and ... by Q317. Preliminary efficacy data from the 15-patient, run-in ... mid-year (recruitment in the 226-patient Phase IIb component is ...
(Date:3/23/2017)... New York , March 23, 2017 /PRNewswire/ ... market exhibits a consolidated vendor landscape with the top ... overall market in 2015. These companies are Stryker ... Inc., Hygia Health Services, Inc., and VANGUARD AG. ... reprocessed medical devices market is witnessing the prevalence ...
Breaking Medicine Technology: