Navigation Links
Drugs That Shift Cell's Energy Find New Purpose
Date:2/15/2010

Researchers eye them as new treatments for heart disease, other conditions

MONDAY, Feb. 15 (HealthDay News) -- Researchers have identified several drugs that can change the way cells convert nutrients into energy, and they could potentially be used to treat heart attack, stroke and other conditions.

"Shifts in cells' energy production pathways take place naturally during development and in response to demanding activities -- like sprinting versus long-distance running. They are also known to be involved in several disease states," study leader Dr. Vamsi Mootha, of the Center for Human Genetic Research at Massachusetts General Hospital, said in a news release from the hospital.

"We wanted to identify compounds that can safely induce this shift -- those that have previously been discovered are too toxic -- and investigate their therapeutic potential in animal models," Mootha said.

Mootha and colleagues screened almost 3,700 compounds and pinpointed several U.S. Food and Drug Administration-approved drugs -- including an over-the-counter anti-nausea drug -- that can shift cellular energy.

The study was published Feb. 14 online in the journal Nature Biotechnology.

The findings may eventually lead to new treatments for some serious health problems, but much more research is needed, the researchers noted.

"Before we can think about human studies, we need to do rigorous animal testing to determine optimal, safe dosing regimens and learn more about how [these] drugs work," said Mootha, an assistant professor of systems biology at Harvard Medical School.

More information

The American Heart Association outlines heart attack treatments.



-- Robert Preidt



SOURCE: Massachusetts General Hospital, news release, Feb. 14, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Diabetes Drugs Avandia, Actos Tied to Fractures in Women
2. Adapting to clogged airways makes common pathogen resist powerful drugs
3. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
4. The private sale of drugs in public hospitals
5. Glaucoma Drugs May Play Role in Longer Life
6. Rehabilitation for Opiate Addiction Without Maintenance Drugs
7. Review and approval of oncology and hematology drugs at FDA from 2005 to 2007
8. Fake Drugs Bought on the Web Pose Big Health Risks
9. Scientists show how molecular switch helps pancreatic cancer beat drugs
10. Common antidepressant drugs linked to lactation difficulties in moms
11. Counterfeit Internet drugs pose significant risks and discourage vital health checks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join ... wage raise to $12 an hour by 2020 and then adjusting it yearly to increase ... of the minimum wage, assure the wage floor does not erode again, and make future ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HILLS, Calif. , June 23, 2016 Any ... the many challenges of the current process. Many of them ... because of the technical difficulties and high laboratory costs involved. ... have to offer it at such a high cost that ... afford it. Dr. Parsa Zadeh , founder ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
Breaking Medicine Technology: