Navigation Links
Drugs That Shift Cell's Energy Find New Purpose
Date:2/15/2010

Researchers eye them as new treatments for heart disease, other conditions

MONDAY, Feb. 15 (HealthDay News) -- Researchers have identified several drugs that can change the way cells convert nutrients into energy, and they could potentially be used to treat heart attack, stroke and other conditions.

"Shifts in cells' energy production pathways take place naturally during development and in response to demanding activities -- like sprinting versus long-distance running. They are also known to be involved in several disease states," study leader Dr. Vamsi Mootha, of the Center for Human Genetic Research at Massachusetts General Hospital, said in a news release from the hospital.

"We wanted to identify compounds that can safely induce this shift -- those that have previously been discovered are too toxic -- and investigate their therapeutic potential in animal models," Mootha said.

Mootha and colleagues screened almost 3,700 compounds and pinpointed several U.S. Food and Drug Administration-approved drugs -- including an over-the-counter anti-nausea drug -- that can shift cellular energy.

The study was published Feb. 14 online in the journal Nature Biotechnology.

The findings may eventually lead to new treatments for some serious health problems, but much more research is needed, the researchers noted.

"Before we can think about human studies, we need to do rigorous animal testing to determine optimal, safe dosing regimens and learn more about how [these] drugs work," said Mootha, an assistant professor of systems biology at Harvard Medical School.

More information

The American Heart Association outlines heart attack treatments.



-- Robert Preidt



SOURCE: Massachusetts General Hospital, news release, Feb. 14, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Diabetes Drugs Avandia, Actos Tied to Fractures in Women
2. Adapting to clogged airways makes common pathogen resist powerful drugs
3. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
4. The private sale of drugs in public hospitals
5. Glaucoma Drugs May Play Role in Longer Life
6. Rehabilitation for Opiate Addiction Without Maintenance Drugs
7. Review and approval of oncology and hematology drugs at FDA from 2005 to 2007
8. Fake Drugs Bought on the Web Pose Big Health Risks
9. Scientists show how molecular switch helps pancreatic cancer beat drugs
10. Common antidepressant drugs linked to lactation difficulties in moms
11. Counterfeit Internet drugs pose significant risks and discourage vital health checks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
Breaking Medicine Technology: