Navigation Links
Drugs May Not Slow Kidney Damage in Diabetes
Date:7/1/2009

Study uncovers possible benefit, though, in stemming vision loss,,

WEDNESDAY, July 1 (HealthDay News) -- Results from a new trial have dashed hopes that early use of two blood pressure drugs could slow the loss of kidney function caused by type 1 diabetes.

But the study, reported in the July 2 issue of the New England Journal of Medicine, does find benefits for the drugs against diabetes-caused eye damage.

Type 1 diabetes, the less common form of the disease, results from the body's failure to produce insulin and usually is diagnosed early in life. The two drugs in the trial, enalapril (Vasotec) and losartan (Hyzaar), are commonly prescribed to slow the kidney damage caused by the disease, said Dr. Michael Mauer, a professor of pediatrics and medicine at the University of Minnesota and lead author of the study.

"They are widely used at later stages of the disease, when it is well established," Mauer said. "Some physicians have been willing to extrapolate to treat at very early stages of the condition, but no studies such as ours had been conducted."

The trial included 285 people who had been treated for type 1 diabetes for an average of 11 years. Current practice, Mauer said, is for use of the two drugs to begin about 15 years after diagnosis.

Participants were assigned to take daily doses of a placebo -- an inactive substance -- or either enalapril or losartan. Each acts in a different way to counter the effects of angiotensin, which raises blood pressure by tightening arteries.

After about five years, detailed measurements of kidney function showed no difference in the damage seen in the three groups, the report said.

"From the kidney perspective, it was more of a disappointment than a surprise," Mauer said. "We were more pleasantly surprised by the eye component of the study."

Eye damage was reduced by 65 percent among the participants taking enalapril and by 70 percent among those who took losartan, compared with people in the placebo group.

And so, Mauer said, "the data in the paper support starting this therapy in people who have early diabetic eye changes." Diabetes is a leading cause of vision loss, he noted.

But he added a word of caution. Both drugs can cause fetal damage so they should not be prescribed for women of child-bearing age, he said.

"Other than that, they have a remarkable safety profile," Mauer said.

The study was funded by Merck, which makes both drugs, along with the U.S. National Institutes of Health and the Canadian Institutes of Health Research.

Mauer said that the study results should not affect current use of the drugs in later stages of type 1 diabetes. "They are commonly used for people who already have signs of kidney disease," he said. "They have been shown to have more effective blood pressure effects than other drugs, and they seem to have additional advantages in slowing the progression of kidney disease."

The findings, though, are limited to type 1 diabetes, he said. "I'd be uncomfortable extrapolating from our study to type 2 diabetes," Mauer said. Type 2 diabetes, the more common form of the condition, generally occurs later in life as the body progressively produces less insulin.

More information

The American Diabetes Association has more on type 1 diabetes.



SOURCES: Michael Mauer, M.D., professor, pediatrics and medicine, University of Minnesota, Minneapolis; July 2, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New review suggests caution on drugs to raise good cholesterol
2. Can cancer drugs combine forces?
3. Study provides hope that some transplant patients could live free of antirejection drugs
4. Study provides hope that some transplant patients could live free of anti-rejection drugs
5. RA Drugs Linked to Slight Skin Cancer Risk
6. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
10. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
11. 2 drugs equally effective for heart patients undergoing angioplasty, Mayo study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drugs May Not Slow Kidney Damage in Diabetes
(Date:5/4/2016)... , ... May 04, 2016 , ... Nike Rugby Camp's ... rugby in San Diego. Willis, founder of Elite Rugby Camps and current Nike Camp ... players every year since 2009. , “I’m excited for our eighth summer here ...
(Date:5/4/2016)... ... 04, 2016 , ... Hight-Doland Insurance Agency’s new community involvement program which serves ... Big Sisters of Southwest Louisiana to help provide positive mentoring for local youth. Donations ... Big Sisters of Southwest Louisiana has been helping to guide the area’s youth for ...
(Date:5/4/2016)... ... May 04, 2016 , ... May kicked off with Melanoma ... United States. Dermatologist Dr. Ellen Turner is encouraging her patients, as well as residents ... on skin safety and health now and in the future. , The dermatology-specific awareness ...
(Date:5/4/2016)... ... May 04, 2016 , ... Momsense, Inc. ... mothers. The company’s patented technology, The Smart Breastfeeding Meter, is designed to monitor ... the technology is now available for purchase at Target.com . , ...
(Date:5/4/2016)... ... ... Francesca Loparco, Co-Founder of Queen City Dream Cars, an exotic car rental ... at Christenbury Eye Center. The entrepreneur struggled with her computer, riding horses and ... as her in-office consultation and eye exam. Francesca’s eyesight was restored to 20/20 in ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... LAWRENCEVILLE, N.J. , May 2, 2016 /PRNewswire/ ... drug development company, today announced data from the ... dose escalating clinical trial (the OVATION Study) combining ... of care for the treatment of newly-diagnosed patients ... chemotherapy followed by interval debulking surgery.  In the ...
(Date:4/29/2016)... 2016  In the next ten years, the ... systems dependent on CRTs monitors to those reliant on ... Medical monitors and will automatically sync to existing ... foreseeable benefits to this technological advancement, it also ... to be replaced in order to be LCD ...
(Date:4/29/2016)... , April 29, 2016 ... for Life Sciences, Product Development Capabilities in ... Science Customer Base . Indegene ... today announced the acquisition of Skura Corporation,s life ... leader in adaptive sales enablement technology for life ...
Breaking Medicine Technology: