Navigation Links
Drugs From Vegetables May Target Melanoma Tumors

Extracts of broccoli, cabbage block protein in disease spread, study says

THURSDAY, March 5 (HealthDay News) -- A drug based on compounds extracted from cruciferous vegetables such as broccoli and cabbage could offer a potent and safe treatment against melanoma, Penn State College of Medicine researchers say.

In mice, a combination of these vegetable compounds (called isothiocyanates) and selenium slowed production and blocked the signaling network of a protein called Akt3 -- which plays a role in melanoma development, -- and reduced tumor growth by 60 percent.

"There are currently no drugs to target the proteins that trigger melanoma. We have developed drugs from naturally occurring compounds that can inhibit the growth of tumors in mice by 50 to 60 percent with a very low dose," Gavin Robertson, an associate professor of pharmacology, pathology and dermatology, said in a Penn State news release.

The potency of isothiocyanates is so low that a useful drug would require impractically large amounts of the compounds. Instead, the researchers altered the vegetable-based compounds by replacing their sulfur bonds with selenium, resulting in a more powerful drug that can be delivered intravenously at low doses. The new drug is called isoselenocyanate.

"Selenium deficiency is common in cancer patients, including those diagnosed with metastatic melanoma. Besides, selenium is known to destabilize Akt proteins in prostate cancer cells," Robertson said.

When the researchers tested the combination drug on different human melanoma cell lines, they found it was from 30 percent to 70 percent effective. Possible human trials of the new drug are still years away.

"We have harnessed something found in nature to target melanoma. And since we only need tiny amounts to kill the cancer cells, it means even less toxic side effects for the patient," said Robertson, who has a provisional patent on the discovery.

The research was published in the March issue of Clinical Cancer Research.

More information

The U.S. National Cancer Institute has more about melanoma.

-- Robert Preidt

SOURCE: Penn State, news release, March 1, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New review suggests caution on drugs to raise good cholesterol
2. Can cancer drugs combine forces?
3. Study provides hope that some transplant patients could live free of antirejection drugs
4. Study provides hope that some transplant patients could live free of anti-rejection drugs
5. RA Drugs Linked to Slight Skin Cancer Risk
6. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
10. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
11. 2 drugs equally effective for heart patients undergoing angioplasty, Mayo study finds
Post Your Comments:
Related Image:
Drugs From Vegetables May Target Melanoma Tumors
(Date:6/27/2016)... ... June 27, 2016 , ... recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... develops, markets and sells medical devices and wearable sleep ... a strategic cooperation agreement with Hongyuan Supply Chain Management ... on June 20, 2016, to develop Dehaier,s new Internet ... agreement, Dehaier will leverage Hongyuan Supply Chain,s sales platform ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: