Navigation Links
Drug trials funded by industry are more likely to publish favorable results
Date:8/2/2010

Boston, Mass. -- When published results are systematically tracked for drug trials registered with ClinicalTrials.gov, those from industry-funded trials are the likeliest to be favorable to the drug in question, report researchers at Children's Hospital Boston. Publishing in the August 3 issue of the Annals of Internal Medicine, the researchers call for more public disclosure about clinical drug trials at their outset to reduce the possibility of bias in the findings.

The research team, led by Florence Bourgeois, MD, MPH, of Children's Division of Emergency Medicine, and Kenneth Mandl, MD, MPH, Laboratory Director in the Children's Hospital Informatics Program, reviewed 546 drug trials conducted between 2000 and 2006 and listed with ClinicalTrials.gov, a comprehensive, web-based federal registry of clinical trials. The analysis focused on five classes of drugs: cholesterol-lowering drugs, antidepressants, antipsychotics, proton-pump inhibitors and vasodilators. The researchers scanned the medical literature for publications associated with each trial, checking four separate databases and contacting trial investigators directly if necessary.

Overall, allowing for a three-year lag time from the completion of the trial, two-thirds of the trials had published results. The industry-funded trials reported positive outcomes 85 percent of the time, as compared with 50 percent for government-funded trials and 72 percent for trials funded by nonprofits or non-federal organizations. In addition, among the nonprofit/nonfederal trials, those that had industry contributions (nearly half) were more likely than those without to report positive outcomes (85 vs. 61 percent). These differences were all statistically significant.

The researchers acknowledge that the pharmaceutical industry was probably more selective in which trials it funded, helping to account for their greater proportion of favorable outcomes. "Industry is very good at knowing
'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Clinical trials can be improved by managing the learning curve
2. Many False-Positive HIV Test Results for Those in AIDS Vaccine Trials
3. Hopkins faculty lead development of report to FDA on ethical, scientific issues related to post-market clinical trials
4. Announcing: Intrinsic Imaging : Radiology Experts Launch Novel Medical Imaging CRO for Clinical Trials
5. US Department of Defense helps move spinal cord injury treatment closer to clinical trials
6. Second Ohio State cancer drug begins clinical trials testing
7. Compound enhances cancer-killing properties of agent in trials
8. Newer Drugs Beat Gleevec in Head-to-Head Trials
9. Nicer than needles: Insulin pills for diabetes finally in clinical trials
10. Trials begin on potent new hepatitis C drug
11. Quincy Bioscience Launches HOPETrials.com; Research Studies More Accessible For Participants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Now that the holiday season is here, ... nation's leading cash-for-junk-cars companies, is improving their cash offers ... competitive and help bring a little bit more joy ... year. , Along with purchasing expensive gifts for family ... deal with large travel expenses during the holiday season. ...
(Date:11/28/2014)... November 28, 2014 Novatus, a ... its Release v5.1 which provides customers with greater ... options. , “As we continue to evolve ... provide more functionality and improved performance in response ... CEO for Novatus. “With the enhancements that we ...
(Date:11/28/2014)... Wisconsin (PRWEB) November 28, 2014 Dr. ... plastic surgeons , announced the expansion of Quintessa Aesthetic ... center will be located at W307 N1497 Golf Road ... , According to Dr. Campbell, the new Delafield location ... procedures for patients, including: Botox, filler injectables ...
(Date:11/28/2014)... Texas (PRWEB) November 28, 2014 Dr. Paul Vitenas, ... will hold a Glitter & Glow Holiday Event for those in ... treatments offered at his practice. Glitter & Glow will take place ... Dr. Vitenas’ new location in the heart of Houston at 4208 ... of holidays and hope that you will come and celebrate the ...
(Date:11/28/2014)... Written and narrated by award winning author ... “The Happiest Man In the World: Life Lessons From ... and why Project C.U.R.E. came to be. , Raised in ... the Reverend Richard W. Jackson, Dr. Jackson exceeded his goal ... realized that he wasn’t happy. Prompted by this realization, James ...
Breaking Medicine News(10 mins):Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Novatus Releases v5.1 with New Advanced Reporting Capabilities 2Health News:Dr. Andrew Campbell to Expand Quintessa Aesthetic Center into Delafield 2Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 2Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 3Health News:Thanksgiving Weekend Audiobook Treat! “The Happiest Man In the World: Life Lessons From a Cultural Economist” by Dr. James W. Jackson 2
... Christmas Programs and Next Year,s Services , ... in Chicago is facing a grave financial shortfall which will ... pace of donations increases this Christmas season according to its ... , "The economic downturn has attacked us ...
... of millions of people, mainly in developing countries, are ... Organization. , More than 12 million people in ... spread by the bite of infected sand flies. Nearly ... people die from the disease annually. , Researchers ...
... high-energy diet pill really save your job? It seems that ... and other retailers are seeing a significant drop in sales ... is reporting dramatically increased sales of Zantrex-3 (R), their ... (Photo: http://www.newscom.com/cgi-bin/prnh/20081216/LA52707 ) , , ...
... in mucus could fight deadly,bacteria in lungs , , TUESDAY, ... that stain the mucus in the lungs of cystic ... infections, researchers say. , The pigments may enable infectious ... communities, according to a Massachusetts Institute of Technology (MIT) ...
... that they know. Or maybe not. A new study published in Human ... human genome must pay attention to ancestry when analyzing and interpreting their ... ... someone where their ancestors were from and odds are that they know. ...
... Health (NIH) has awarded nearly $3 million to support Rush ... the health outcomes and health care cost savings for very ... , The grant will enable researchers at Rush to ... 600 very low birth weight infants born to racially and ...
Cached Medicine News:Health News:Salvation Army Services Threatened by Pace of Donations 2Health News:UIC researchers hunting drugs for devastating parasitic disease 2Health News:Sales of Energy-Boosting Diet Pills Skyrocket as the Economy Falters 2Health News:Scientists Spot Key to Cystic Fibrosis Infections 2Health News:Genome-wide Association Studies Must Account for Ancestry 2Health News:Genome-wide Association Studies Must Account for Ancestry 3Health News:Study examines how breastfeeding impacts cost of care for very low birth weight infants 2
(Date:11/26/2014)... Nov. 26, 2014  Over 100 million adults suffer ... from this pain daily. Chronic and acute pain dramatically ... is born to fulfill the need for non-surgical, interventional ... pain. On October 28th, a new pain ... Cumberland, Maryland community.  This new facility boasts ...
(Date:11/26/2014)...  BioScrip ® , Inc. (NASDAQ: BIOS ) announced ... Officer, will present at the Bank of America Merrill Lynch 2014 ... Date: , , , Wednesday, December 3, 2014 , , ... , , , Location: , , , Boca Raton Resort and ... BioScrip, Inc. is a leading national provider ...
(Date:11/26/2014)... a leader in the development of Chimeric Antigen Receptors ... cancers, today announced the completion of a series A ... -based healthcare private equity fund.   CARsgen ... new therapeutics for liver, lung, stomach and brain cancers. ... Hospital, the company plans to initiate clinical studies for ...
Breaking Medicine Technology:New Pain Management Center Opens in Cumberland, Md. 2CARsgen Completes Series A Financing 2
... AdvanDx today announced the FDA,510(k) submission of ... of,Candida yeast species from positive blood cultures. ... AdvanDx,s easy-to-use, molecular-based PNA,FISH(TM) diagnostics platform that ... instead of days. Candidemia, a bloodstream,infection caused ...
... FORT WORTH, Texas, June 3 Wound Care,Innovations, ... MB Software Corporation (OTC Bulletin Board: MBSB)) announced,today ... evaluating the clinical,performance of their advanced wound care ... a major problem in the elderly and,compromised patients. ...
Cached Medicine Technology:AdvanDx Submits Yeast Traffic Light PNA FISH(TM) for FDA 510(k) Clearance for Detection of Candida species in Positive Blood Cultures 2AdvanDx Submits Yeast Traffic Light PNA FISH(TM) for FDA 510(k) Clearance for Detection of Candida species in Positive Blood Cultures 3Wound Management Technologies, Inc. Announces Evidence Based Study 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: