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Drug trial results refine treatment during angioplasty operations
Date:8/31/2010

erventional cardiologist at the Universit Paris and Hpital Bichat in France and co-chair of the study. "This study's results challenge this hypothesis and suggest that anticoagulation during PCI (percutaneous coronary intervention, or angioplasty) is important in the stent era."

The rates of peri-PCI major bleeding in FUTURA-OASIS 8 (1.4 per cent low dose and 1.2 per cent standard dose) were not significantly different than the rate observed in the fondaparinux arm of the OASIS 5 trial that underwent PCI (1.5 per cent) but lower than the enoxaparin arm of the OASIS 5 trial that underwent PCI (3.6 per cent).

"What this implies is that the standard dose of UFH may be the optimal treatment strategy in PCI patients on fondaparinux while maintaining the major advantage of fondaparinux which is a low rate of major bleeding," said Dr. Salim Yusuf, chair of the FUTURA-OASIS 8 steering committee, a professor of medicine in the Michael G. DeGroote School of Medicine and director of the Population Health Research Institute at McMaster University and Hamilton Health Sciences in Canada.


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Contact: Laura Thompson
lthomp@mcmaster.ca
905-525-9140
McMaster University
Source:Eurekalert

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