Navigation Links
Drug to treat alcoholism goal of UH professor's research
Date:9/20/2010

HOUSTON, Sept. 20, 2010 With the ultimate goal to discover a drug that one day treats alcoholism, a University of Houston (UH) pharmacy professor is working on pinpointing the mechanisms in the brain that respond to alcohol.

Joydip Das, a medicinal chemist and pharmacologist in the UH College of Pharmacy, received a three-year, $450,000 grant this year from the National Institutes of Health (NIH). In the end, his team hopes their research will help lead them to a way to prevent people from drinking in excess.

"Defining targets and elucidating the molecular mechanism of their actions is needed for effective intervention," Das said. "Once we understand the target, then we design drugs based on that target."

More specifically, Das explained that addictions are related to the brain, with protein kinase C (PKC) particularly of the PKCε subtype being mainly expressed in the brain and playing a key role in this process. Previous observations have indicated as much as a 75 percent reduction of alcohol drinking in mice using knockout technology, demonstrating that knocking out the PKCε protein cuts desire.

He says that it's difficult to pinpoint where alcohol acts and what its target is, so his team's objective is to find the target and then determine how it interacts with ion channels to affect the addiction.

"We're looking at the significance of the interaction between the alcohol molecule and PKCε protein. How the alcohol molecule binds with the target is the key," Das said. "This binding has implications in addiction, so our intent is to design drugs to curb the desire for more than a small amount of alcohol so that people stay away from excessive drinking."

Trained at MIT and having worked in the anesthesia department at Massachusetts General Hospital, Das has a particular interest in this area, saying that alcohol also is an anesthetic, with PKCε being one of its many targets.

"Our focus is brain chemistry. In our study, we have seen that PKCε and alcohol interacts and have pinpointed the binding side," he said. "Now, we must determine the molecular mechanism of the interaction. To do so, we are looking at how those two interact in the neuronal cells, which are the impulse-conducting cells in the brain."

The group's next steps will be to progress to animal trials with the mouse model and then ultimately to clinical trials with humans. Working with Das on this project are postdoctoral fellow Satyabrata Pany and undergraduate student Khoi Ly.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
3. Women More Likely to Fail Treatment for Atrial Fibrillation
4. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Nanofilm Introduces Clarity Defog It™ Anti Fog Treatment and EcoClens™ Eco-Friendly Lens Cleaner at Vision Expo East
7. Many veterans not getting enough treatment for PTSD
8. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
9. Parents often wait too long to treat childrens asthma symptoms
10. Allegheny General Hospital Study Demonstrates Safety and Potential Efficacy of Oral Allergy Treatment
11. Minorities Not Treated at Higher-Quality Centers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug to treat alcoholism goal of UH professor's research
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
Breaking Medicine Technology: