Navigation Links
Drug to treat alcoholism goal of UH professor's research
Date:9/20/2010

HOUSTON, Sept. 20, 2010 With the ultimate goal to discover a drug that one day treats alcoholism, a University of Houston (UH) pharmacy professor is working on pinpointing the mechanisms in the brain that respond to alcohol.

Joydip Das, a medicinal chemist and pharmacologist in the UH College of Pharmacy, received a three-year, $450,000 grant this year from the National Institutes of Health (NIH). In the end, his team hopes their research will help lead them to a way to prevent people from drinking in excess.

"Defining targets and elucidating the molecular mechanism of their actions is needed for effective intervention," Das said. "Once we understand the target, then we design drugs based on that target."

More specifically, Das explained that addictions are related to the brain, with protein kinase C (PKC) particularly of the PKCε subtype being mainly expressed in the brain and playing a key role in this process. Previous observations have indicated as much as a 75 percent reduction of alcohol drinking in mice using knockout technology, demonstrating that knocking out the PKCε protein cuts desire.

He says that it's difficult to pinpoint where alcohol acts and what its target is, so his team's objective is to find the target and then determine how it interacts with ion channels to affect the addiction.

"We're looking at the significance of the interaction between the alcohol molecule and PKCε protein. How the alcohol molecule binds with the target is the key," Das said. "This binding has implications in addiction, so our intent is to design drugs to curb the desire for more than a small amount of alcohol so that people stay away from excessive drinking."

Trained at MIT and having worked in the anesthesia department at Massachusetts General Hospital, Das has a particular interest in this area, saying that alcohol also is an anesthetic, with PKCε being one of its many targets.

"Our focus is brain chemistry. In our study, we have seen that PKCε and alcohol interacts and have pinpointed the binding side," he said. "Now, we must determine the molecular mechanism of the interaction. To do so, we are looking at how those two interact in the neuronal cells, which are the impulse-conducting cells in the brain."

The group's next steps will be to progress to animal trials with the mouse model and then ultimately to clinical trials with humans. Working with Das on this project are postdoctoral fellow Satyabrata Pany and undergraduate student Khoi Ly.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
3. Women More Likely to Fail Treatment for Atrial Fibrillation
4. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Nanofilm Introduces Clarity Defog It™ Anti Fog Treatment and EcoClens™ Eco-Friendly Lens Cleaner at Vision Expo East
7. Many veterans not getting enough treatment for PTSD
8. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
9. Parents often wait too long to treat childrens asthma symptoms
10. Allegheny General Hospital Study Demonstrates Safety and Potential Efficacy of Oral Allergy Treatment
11. Minorities Not Treated at Higher-Quality Centers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug to treat alcoholism goal of UH professor's research
(Date:4/28/2017)... ... 28, 2017 , ... Accreditation Commission for Health Care (ACHC) ... America (HCAOA). This agreement allows HCAOA members to receive special pricing on ACHC’s ... Accreditation University (AU) educational resources that help prepare HCAOA members for ACHC Accreditation. ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... Getting enough sleep affects much more than ... (NSF), going just 19 hours without sleep can compromise motor reaction time, which can increase ... and Amica Insurance is sharing the following tips from the NSF to help you sleep ...
(Date:4/28/2017)... ... April 28, 2017 , ... Datta Endoscopic Back Surgery ... the revolutionary endoscopic practice under Dr. Datta. Patel is a Board Certified Anesthesiologist, ... patented, revolutionary eDiscSculpt Technique created and used by Datta Endoscopic is unlike traditional ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... People are ... older people. “Wearing a hearing aid doesn’t have the stigma it had when great-grandpa ... Hearing Associates of Greater Boston, in a NALA North American Speaker Series ...
(Date:4/28/2017)... ... April 28, 2017 , ... Intellitec Solutions ... Grove Foundation implement a Microsoft Dynamics GP solution that integrates to their PointClickCare ... that specializes in long-term care, Brooke Grove now has the capability to achieve ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... Calif. , April 19, 2017  IRIDEX Corporation ... will release financial results for the first quarter 2017 ... 2017.  The Company,s management team will host a corresponding ... p.m. ET. Investors interested in listening to ... 707-0665 for domestic callers or (703) 326-3030 for international ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 /PRNewswire/ ... This report on the prostate cancer ... of the global market. Increasing prevalence of prostate ... as innovation in the development of new drugs ... hormone-refractory prostate cancer drug due to lesser side ...
(Date:4/19/2017)... India , April 19, 2017 ... and Application, Forecast to 2022 report has covered and analysed ... statistics and information on market size, shares and growth factors. ... major drivers, challenges and opportunities in the global market. ... Browse 152 Tables and Figures, ...
Breaking Medicine Technology: