Navigation Links
Drug to treat alcoholism goal of UH professor's research
Date:9/20/2010

HOUSTON, Sept. 20, 2010 With the ultimate goal to discover a drug that one day treats alcoholism, a University of Houston (UH) pharmacy professor is working on pinpointing the mechanisms in the brain that respond to alcohol.

Joydip Das, a medicinal chemist and pharmacologist in the UH College of Pharmacy, received a three-year, $450,000 grant this year from the National Institutes of Health (NIH). In the end, his team hopes their research will help lead them to a way to prevent people from drinking in excess.

"Defining targets and elucidating the molecular mechanism of their actions is needed for effective intervention," Das said. "Once we understand the target, then we design drugs based on that target."

More specifically, Das explained that addictions are related to the brain, with protein kinase C (PKC) particularly of the PKCε subtype being mainly expressed in the brain and playing a key role in this process. Previous observations have indicated as much as a 75 percent reduction of alcohol drinking in mice using knockout technology, demonstrating that knocking out the PKCε protein cuts desire.

He says that it's difficult to pinpoint where alcohol acts and what its target is, so his team's objective is to find the target and then determine how it interacts with ion channels to affect the addiction.

"We're looking at the significance of the interaction between the alcohol molecule and PKCε protein. How the alcohol molecule binds with the target is the key," Das said. "This binding has implications in addiction, so our intent is to design drugs to curb the desire for more than a small amount of alcohol so that people stay away from excessive drinking."

Trained at MIT and having worked in the anesthesia department at Massachusetts General Hospital, Das has a particular interest in this area, saying that alcohol also is an anesthetic, with PKCε being one of its many targets.

"Our focus is brain chemistry. In our study, we have seen that PKCε and alcohol interacts and have pinpointed the binding side," he said. "Now, we must determine the molecular mechanism of the interaction. To do so, we are looking at how those two interact in the neuronal cells, which are the impulse-conducting cells in the brain."

The group's next steps will be to progress to animal trials with the mouse model and then ultimately to clinical trials with humans. Working with Das on this project are postdoctoral fellow Satyabrata Pany and undergraduate student Khoi Ly.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
3. Women More Likely to Fail Treatment for Atrial Fibrillation
4. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Nanofilm Introduces Clarity Defog It™ Anti Fog Treatment and EcoClens™ Eco-Friendly Lens Cleaner at Vision Expo East
7. Many veterans not getting enough treatment for PTSD
8. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
9. Parents often wait too long to treat childrens asthma symptoms
10. Allegheny General Hospital Study Demonstrates Safety and Potential Efficacy of Oral Allergy Treatment
11. Minorities Not Treated at Higher-Quality Centers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug to treat alcoholism goal of UH professor's research
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... 2016 , ... People across the U.S. are sharpening their pencils and honing ... contest in which patients and their families pay tribute to a genetic counselor by ... Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
Breaking Medicine Technology: